Guide to the Arthur Kornberg Papers
Daniel Hartwig
Stanford University. Libraries.
Department of Special Collections and University Archives
1998
Copyright © 2015 The Board of Trustees of the Leland Stanford Junior University. All rights reserved.
Note
This encoded finding aid is compliant with Stanford EAD Best Practice Guidelines, Version 1.0.
Overview
Call Number: SC0359
Creator:
Kornberg, Arthur, 1918-2007
Title: Arthur Kornberg papers
Dates: 1938-2007
Physical Description:
52 Linear feet and 400 megabytes
Language(s): The materials are in English.
Repository:
Department of Special Collections and University Archives
Green Library
557 Escondido Mall
Stanford, CA 94305-6064
Email: specialcollections@stanford.edu
Phone: (650) 725-1022
URL: http://library.stanford.edu/spc
Administrative Information
Provenance
Custodial History
Gift of Arthur Kornberg, 1989, 2002, 2008.
Information about Access
Search files and other personnel files are restricted.
Ownership & Copyright
Property rights reside with the repository. Literary rights reside with the creators of the documents or their heirs. To obtain
permission to publish or reproduce, please contact the Public Services Librarian of the Dept. of Special Collections and University
Archives.
Cite As
[Identification of item], Arthur Kornberg Papers, SC0359, Stanford University Archives, Stanford, Calif.
Associated Materials
Biography
During a research career spanning more than sixty years, Arthur Kornberg made many outstanding contributions to molecular
biology. He was the first to isolate DNA polymerase, the enzyme that assembles DNA from its components, and the first to synthesize
DNA in a test tube, which earned him a Nobel Prize in 1959. He later became the first to replicate an infective virus DNA
in vitro. He was the primary architect and first chairman of the Department of Biochemistry at the Stanford University School
of Medicine, which under his guidance became a preeminent center for DNA research, including recombinant DNA research. Starting
in the 1980s, Kornberg also played a key role in establishing productive ties between academic science and the biotechnology
industry.
Kornberg was born in Brooklyn, New York on March 3, 1918, the youngest of Joseph and Lena Kornberg's three children. Emigrants
from eastern Europe, the Kornbergs owned a small hardware and home furnishings store. Arthur was "an eager and able student"
and was allowed to skip grades several times in primary school. He finished high school at age 15, and entered the City College
of New York in 1933. Despite this precocity, Kornberg doesn't recall having any early passion for science, or interest in
the natural world as a youngster. (He collected matchbook covers rather than butterflies.) He did well in his high school
and college chemistry courses, and briefly considered an academic career in the field. During the Depression years, however,
medical school seemed a more promising choice. Kornberg received his MD from the University of Rochester in 1941, expecting
to become "an internist with academic connections." Following his internship, he began his World War II military service as
a ship's doctor on a U.S. Coast Guard vessel in the Caribbean. Though he often quarreled with the ship's captain, Kornberg
expected to remain on sea duty for the duration of the war.
Kornberg's career took an unexpected turn when his first medical article was published in 1942. In medical school, Kornberg
had conducted a small research study into a disorder (later known as Gilbert syndrome) characterized by excessive bilirubin
in the blood and a mild benign jaundice, because he himself had the condition. At the time of publication, senior military
medical officers, along with National Institutes of Health (NIH) director Rolla Dyer, were desperately seeking out new information
on jaundice, due to an outbreak of jaundice induced by the new yellow fever vaccine. [To learn more about yellow fever vaccine,
visit the Wilbur Sawyer Papers on Profiles in Science.] Impressed by Kornberg's study, Dyer arranged his reassignment to a
research post in the Nutrition Laboratory at NIH in the fall of 1942. His first project involved tracking down a vitamin deficiency
in rats induced by sulfa drugs. Studying the vitamins then known--many of which are coenzymes--Kornberg became intrigued by
the central role of enzymes in all living processes, and their immense potential for illuminating the mechanisms of cells.
In 1945, desiring to pursue studies of the metabolic enzymes involved in adenosine triphosphate (ATP) production, he received
leave to spend a year acquiring further biochemistry training with Severo Ochoa at New York University, and six months with
Carl and Gerty Cori at Washington University in St. Louis. It was then, he later recalled, that he began a lifelong love affair
with enzymes, the large specialized proteins that catalyze all life processes.
Several years before, Kornberg had married the other love of his life, biochemist Sylvy Ruth Levy. They had met at the University
of Rochester and became better acquainted at NIH, where Sylvy was working at the National Cancer Institute. Apart from the
six years when their sons Roger, Thomas, and Kenneth were small, Sylvy worked full-time in Kornberg's laboratory throughout
their long marriage. The children were often with them there outside of school hours, and two of them, Roger and Thomas, also
chose careers in biochemistry. Roger Kornberg went on to receive the 2006 Nobel Prize in Chemistry.
After Kornberg returned to NIH in 1947, he established an Enzyme Section within the Institute of Arthritis and Metabolic Diseases,
and continued research into the enzymes involved in metabolic respiration. During the next several years he became very adept
at identifying and purifying enzymes, and discovered those that make several key components of metabolic respiration cycles.
Encouraged by his success with these systems, he turned his attention to finding the enzyme that assembles various chemical
building blocks into the nucleic acids: DNA and RNA. He began by working out the synthesis process for the individual nucleotides,
units composed of a nitrogenous base (cytosine, adenine, guanine, uracil, or thymine) combined with a sugar (ribose or deoxyribose)
and a phosphate group.
In 1953, Kornberg moved to St. Louis to head the Microbiology Department at Washington University School of Medicine. There
he continued working on the synthesis of individual nucleotides, and by 1954 had found the enzymes needed to make all four
of the nucleotide building blocks for RNA. A colleague at Washington University had meanwhile found the enzyme that makes
the thymine nucleotide (which substitutes for the uracil nucleotide in DNA). Now able to make the building blocks, Kornberg
and his colleagues began looking for the enzymes that would put them together into RNA or DNA.
Kornberg focused on the synthesis of DNA after learning in 1955 that Severo Ochoa and his colleagues at NYU had apparently
created a synthetic RNA from adenosine diphosphate (ADP) (the product ultimately turned out to be not RNA, but a chain very
like it). Working with cell extracts of E. coli bacteria and radioisotope tracers, Kornberg found which combinations of the
nucleotides and other ingredients resulted in the most rapid synthesis of DNA. By the following year he had found and purified
the essential enzyme, DNA polymerase, from E. coli, and was able to synthesize DNA in the lab. The results were published
in 1958, and Kornberg received the 1959 Nobel Prize in Physiology or Medicine (shared with Severo Ochoa) for this work.
Shortly before the Nobel Prizes were announced that year, Kornberg had taken up a new position as chair of the new department
of biochemistry at the Stanford University School of Medicine in Palo Alto. Stanford had approached him in 1957, offering
the unique opportunity to organize and staff the department from the ground up. Kornberg recruited most of his Washington
University faculty and staff, and a number of former postdoctoral fellows for Stanford. Retaining the communal laboratory
structure and style that they developed in St. Louis, Stanford's department of biochemistry remained a highly productive,
tightly-knit group focused mainly on DNA research. Nearly fifty years later, six of the original faculty--Kornberg, Robert
Baldwin, Paul Berg, David Hogness, Dale Kaiser, and Robert Lehman--were still there.
In this stimulating environment, Kornberg and his colleagues continued to identify and delineate the workings of various enzymes
involved in DNA replication. In 1967 they synthesized a viable virus DNA, an achievement lauded by the press (to Kornberg's
dismay) as the "creation of life in a test tube." They subsequently found enzymes responsible for DNA repair and rearrangement,
and others responsible for the start and elongation of DNA chains and chromosomes. The enzymes they discovered, which allowed
the manipulation of DNA, helped make possible the development of recombinant DNA technology and the engineering of genes and
chromosomes.
In 1991, after many decades of research on DNA replication, Kornberg switched his research focus to inorganic polyphosphate
(poly P), a phosphate polymer. Poly P is found in every bacterial, plant and animal cell, but its functions were not well
understood. Chemists long regarded it as a molecular fossil, a remnant from earlier evolutionary stages. Kornberg found a
variety of likely functions for poly P that include regulating cell responses to stress, and factors responsible for motility
and virulence in some of the major disease microorganisms.
In addition to his research and administrative duties, Kornberg also taught graduate, medical, and postdoctoral students.
With his own and other Stanford departments so closely involved in the early development of recombinant DNA science, he was
long interested in building connections between academic scientists and the emerging biotechnology industry. He was a founding
partner of an innovative research institute (DNAX Institute of Molecular and Cellular Biology) in 1980, and served on the
advisory boards and councils of many university, governmental, and industrial research institutes.
Kornberg published over three hundred scientific papers during his long career, as well as major monographs on DNA replication,
a scientific autobiography, an insider's account of the biotechnology industry, and most recently a children's book, titled
Germ Stories, based on stories he told his children and grandchildren over the years.
Besides the 1959 Nobel Prize, Kornberg received numerous other honors, including election to the National Academy of Sciences
in 1957, election to the Royal Society of London in 1970, and the National Medal of Science in 1979. He received many honorary
doctorates, and in 1999 the University of Rochester dedicated the new Arthur Kornberg Medical Research Building in his honor.
Arthur Kornberg died on October 26, 2007 at the Stanford Hospital, of respiratory failure. He was carrying on his lab research
until several days before his death.
Scope and Content
Collection documents Kornberg's work concerning the synthesis of DNA in the laboratory, as well as the synthetic pathways
of nucleotides, and includes correspondence, 1947 to 1982; research lab notebooks, 1947 to 1969 (which include those studies
for which he received the Nobel Prize in Chemistry in 1959); coursework, lectures, and seminars; Stanford University Departmental
records; records concerning professional organizations; and reprints, glass research slides, and audiotapes.
Arrangement note
The materials are arrenged in eight series: 1. Correspondence; 2. Research and Laboratory Notebooks; 3. Lectures and Seminars;
4. Professional Files; 5. Class Materials; 6. Stanford Administrative and Departmental Records; 7. Personal and Miscellaneous
Papers; 8. Audiovisual materia; and two additions.
Access Terms
Stanford University. School of Medicine. Dept. of Biochemistry--Faculty.
DNA--Synthesis.
Nobel Prize winners
Nobel prize--Stanford faculty--biochemistry
Collection Contents
Series 1
Correspondence
1947-1987
Stanford Correspondence,
1957-1975
Box 31, Folder 8
Stanford Correspondence
1957
Box 31, Folder 7
Stanford Correspondence
1958
Box 31, Folder 9
Stanford Correspondence,
Jul-Dec 1958
Box 31, Folder 3
Stanford Correspondence A-Co,
1961
Box 31, Folder 4
Stanford Correspondence Co-Me,
1961
Box 31, Folder 5
Stanford Correspondence Me-R,
1961
Box 31, Folder 6
Stanford Correspondence Sa-Y,
1961
Box 31, Folder 15
Stanford Correspondence
1961-1966
Box 26, Folder 13
Stanford Correspondence
1967-1968
Box 28, Folder 8
Stanford Correspondence
1969-1972
Box 30, Folder 2-4
Stanford Correspondence: Medical Search Committee
1972-1975
Box 30, Folder 8
Library Correspondence
1958-1964
Box 31, Folder 14
Library Correspondence
1960-1961
General Correspondence,
1947-1987
Box 11, Folder 3
Correspondence R-XYZ,
1977
Box 12, Folder 1
Correspondence A-C,
1980-1981
Box 12, Folder 2
Correspondence D-I,
1980-1981
Box 12, Folder 3
Correspondence J-P,
1980-1981
Box 12, Folder 4
Correspondence Q-S,
1980-1981
Box 6, Folder 4
Correspondence T-Z,
1980-1981
Box 6, Folder 8
Correspondence A-E,
1983-1984
Box 6, Folder 9
Correspondence F-J,
1983-1984
Box 7, Folder 1
Correspondence K-R,
1983-1984
Box 7, Folder 2
Correspondence S-Z,
1983-1984
Box 7, Folder 3
Correspondence A-G,
1985-1986
Box 7, Folder 4
Correspondence H-N,
1985-1986
Box 7, Folder 5
Correspondence O-Z,
1985-1986
Box 2, Folder 14
Benno C. Schmidt, correspondence and papers,
1974-82
Box 18, Folder 13
Bellagio Study and Conference Center, correspondence,
1975
Box 26, Folder 10
American Professors for Peace in the Middle East, Correspondence,
1967-1969
Box 26, Folder 11
Student Reports, DNA, Correspondence,
1961-1969
Box 26, Folder 12
Whiting file, Correspondence,
1964-1965
Box 26, Folder 4-8
Special Subjects Correspondence,
1967
Box 26, Folder 9
Journal of Biological Chemistry, Correspondence with,
1953-1962
Box 28, Folder 6
Germany/Israel Trip,
Oct-Nov 1971
Box 29, Folder 7
Guggenheim Foundation,
1968-1972
Box 30, Folder 1
Correspondence, Prism magazine, Genetic disease and the Support of Science
1973,
Box 30, Folder 11
Academic Press, correspondence re: publication of manuscript, included, "Bacterial DNA Polymerases,"
1973
Box 31, Folder 10
Correspondence, Cranks,
1959
Box 31, Folder 11
Correspondence re: Nobel Lecture,
1959-1960
Box 31, Folder 12
Correspondence, Sweden,
1959-1960
Box 31, Folder 13
Correspondence, Political,
1961-1964
Box 32, Folder 6
Correspondence re: remodeling,
1965-1966
Box 32, Folder 7
Correspondence MA General Hospital Advisor's Committee,
1965-1966
Box 32, Folder 8
ASBC President, Correspondence,
1965-1966
Series 2
Research and Laboratory Notebooks
1938-1970
Box 7, Folder 7
Ion Exchange [Dataleaflets/Graphs]
Box 15, Folder 1-10
Medical student notes,
1938-41
Box 16, Folder 9
Lab Notebooks: Berkley Brookhaven Boulder
1951; 1955; 1958
Box 16, Folder 10
Lab Notebooks: Pacific Grove
1953
Box 16, Folder 11-17
Lab Notebooks: SK
1953-[1957]
Box 17, Folder 1
Lab Notebooks: SK Polymerase I & II,
1958; 1958-1959
Box 17, Folder 2
Lab Notebooks: Johnson Polymerase
1961 Dec-1962 Apr
Box 17, Folder 4-5
Lab Notebooks: New England Enzyme Center: Enzyme Preparations and Fermentations
Box 17, Folder 6
Lab Notebooks: PRPP Book 1 [Vancouver],
Jan-Feb 1957
Box 17, Folder 7
Lab Notebooks: PRPP Book 2 [Vancouver II],
Feb 7-Feb 16, 1957
Box 19, Folder
Lab Notebooks: NYU (v. 1-17)
1947-1951
Box 20, Folder
Lab Notebooks: NYU (v. 18-21)
1951-1953
Box 20, Folder
Lab Notebooks: (v. 22-33)
1954-1958
Box 21, Folder
Lab Notebooks: (v. 34-49)
1958-1967
Box 22, Folder
Lab Notebooks: (v. 51-65)
1963-1969
Box 23, Folder 1
Lab Notebooks: (v. 66-67)
1969
Box 17, Folder 8
Lab Notebooks: Radding
1959-1961
Box 17, Folder 9
Lab Notebooks: Zimmerman
1958-1961
Box 17, Folder 10
Lab Notebooks: Aposnian
1959-1962
Box 17, Folder 12
Lab Notebooks: Swartz
1960-1961
Box 23, Folder 2
Lab Notebooks: Bertsch Em
1969-1970
Box 23, Folder 3
Lab Notebooks: Atkinson
1968
Box 23, Folder 4
Lab Notebooks: Cozzarelli
1968
Box 23, Folder 5
Lab Notebooks: Wehrli, Jackson, Albettson
(1962 and 1964)
Box 23, Folder 6
Lab Notebooks: Okazaki
1962-1963
Box 23, Folder 7
Lab Notebooks: Okazaki
undated
Box 23, Folder 8
Lab Notebooks: Nussbaum
1961-1963
Box 23, Folder 9
Lab Notebooks: Reichard/Levy/Richardson
undated
Series 3
Lectures and Seminars
1949-1987
Box 3, Folder 16-43
Lectures (off campus)
1972-1974
Box 4
Lectures (off campus)
1975-1981
Box 9, Folder 1-56
Lectures/Symposia
1982-1987
Box 30, Folder 6
Seminars correspondence
1970-1971,
Box 30, Folder 7
Seminars correspondence
1972-1976,
Box 16, Folder 7
St. Louis microbiology lectures,
1956
Box 18, Folder 12
Enzyme substrate complex (seminar)
Box 18, Folder 14-35
Series of speaking engagements
1960s-1970s
Series 4
Professional Files
1947-1987
Box 1, Folder 5-6
Papers submitted for publication,
1967
Box 2, Folder 1-2
Correspondence re: publishing book [DNA Synthesis],
1972-79
Box 2, Folder 11
Weizmann Institute,
1971-1980
Box 2, Folder 12-13
Senate and House Hearings,
1968-1973
Box 2, Folder 15-19
Research support
1972-1977
Box 3, Folder 1
Research support,
1978-83
Box 3, Folder 5
Senator Kennedy letter [re biomedical research and federal funding],
1978
Box 3, Folder 9
Weizmann Leadership Conference, Los Angeles,
June 1981
Box 3, Folder 10
California Medical Association, Anaheim meeting,
1981
Box 3, Folder 11
Aspen Institute for Humanistic Studies - Biomedical Workshop
1981
Box 3, Folder 13
National Science Foundation Research Proposal (Membranes in DNA Replications and the Viral Life Cycle)
1978
Box 3, Folder 15
Aging Grant (DNA Transactions and Aging)
1980-83
Box 9, Folder 57-60
Grants: NSF, NIH
1978-1983, 1982-1987
Box 10, Folder 4-20
Professional organizations, misc. files
Box 13, Folder 7-26
Reports, lectures, trips, plans, preparations,
1953-67
Box 15, Folder 19-22
Miscellaneous research files
Box 25, Folder 7
Wiesmeyer, Herbert,
"The Characterization of the Maltose Permease and Amylomaltose of E. Coli,"Ph.D. Thesis Washington University
1959,
Box 26, Folder 18
National Academy of Sciences,
1968-1969
Box 29, Folder 10
California State Board of Education-Evolution vs. Creation
1972
Box 29, Folder 11
National Academy of Sciences
Box 29, Folder 12
National Academy of Sciences Editorial Board
1966
Box 29, Folder 13
National Academy of Sciences Editorial Board
1965
Box 29, Folder 14
New England Enzyme Center, NIH Panels, reviews, etc.
Box 30, Folder 12
Notebook of Kornberg's reports "Enzymatic Synthesis of DNA"
Series 5
Class Materials
1953-1968
Box 8, Folder 4
Micro-Biology Syllabus
1953
Box 8, Folder 5
Micro-Biology Syllabus
1955
Box 8, Folder 6
Micro-Biology Syllabus
1956
Box 8, Folder 7
Micro-Biology Syllabus
1957
Box 8, Folder 8
Micro-Biology Syllabus
1958
Box 8, Folder 9
Biochemistry 101-102,
1959-1960
Box 8, Folder 10
Biochemistry 101-102,
1961
Box 8, Folder 11
Biochemistry 101-102,
1962
Box 31, Folder 1
Biochemistry 101-102 (examinations and review questions),
1960-1964
Box 14, Folder 1-4
Biochemistry 101-102,
1963-1968
Box 1, Folder 9
General chemistry workshop,
1968
Series 6
Stanford Administrative and Departmental Records
1961-1986
Box 3, Folder 6
Industrial Affiliates Program (Bio Chemistry Dept.),
1980-84
Box 3, Folder 8
Anniversary Scientific Symposia,
1980
Box 3, Folder 14
Roof Project: expansion of biochemistry building,
1980
Box 25, Folder 6
Executive Committee minutes,
1961-62
Box 1, Folder 1-4
Biochemistry dept. minutes
1966-1970
Box 5
Biochemistry dept. records (faculty minutes),
1971-1983
Box 6, Folder 1-3
Biochemistry dept. records (faculty minutes),
1984-1986
Box 30, Folder 9
Binder re Department Responsibilities,
1969-71
Box 30, Folder 10
Executive Committee: minutes, agenda, reports,
1969
Box 1, Folder 13-20
Stanford administrative files,
1968-71
Series 7
Personal and Miscellaneous Papers
1947-1979
Box 14, Folder 5-11
Newspaper clippings,
1967
Box 23, Folder 11
Newspaper clippings, publicity,
1979
Series 8
Audiovisual Materials
1971 and undated
Box 34-35
Slides: illustrations for lectures
Box 36
36.1
Kornberg, Arthur: Membrane structure
1971 Feb 22
Kornberg: Membrane structure,, 1971 Feb 22
Kornberg: Membrane structure,, circa 1650
Physical Description:
1 audiocassette(s)
Box 36
36.2
Roseman, T.J.: Membrane function in permeation
23-Feb-71
Roseman: Membrane function in permeation,, Feb. 23, 1971
Roseman: Membrane function in permeation,, Feb. 23, 1971
Physical Description:
1 audiocassette(s)
Box 36
36.3-36.5
Kornberg, Arthur: Cell envelopes
Feb 24-26, 1971
Kornberg: Cell envelopes,, 1971 Feb 24-26
Kornberg: Cell envelopes,, 1971 Feb 24-26
Kornberg: Cell envelopes,, 1971 Feb 24-26
Kornberg: Cell envelopes,, 1971 Feb 24-26
Kornberg: Cell envelopes,, 1971 Feb 24-26
Kornberg: Cell envelopes,, 1971 Feb 24-26
Physical Description:
3 audiocassette(s)
Box 36
36.6-36.7
Bloch: Steroid structure and synthesis
1971 Mar 2-3
Bloch: Steroid structure and synthesis,, 1971 Mar 2-3
Bloch: Steroid structure and synthesis,, 1971 Mar 2-3
Bloch: Steroid structure and synthesis,, 1971 Mar 2-3
Bloch: Steroid structure and synthesis,, 1971 Mar 2-3
Physical Description:
2 audiocassette(s)
Box 36
36.8
Kornberg, Arthur: Opening address, Cold Spring Harbor
1978
Kornberg: Opening address, Cold Spring Harbor,, 1978
Kornberg: Opening address, Cold Spring Harbor,, 1978
Physical Description:
1 audiocassette(s)
Accession ARCH-2008-108
Additional Material
Access Information
Partially restricted.
Box 1
Others' work: Abir-Am-Cori
Box 2
Others' work: Cozzarelli-Heppel
Box 3
Others' work: Herschlag-Klenow
Box 5
Others' work: Lohman-Okinawa
Box 6
Others' work: Orgel-Thackray
Box 7
Others' work: Thomas-Zuckerman
Box 8
Acmetobacter [Acinetobacter?]-other organisms
Box 11
Seminars
1996 July-1999 Dec.
Box 11
Correspondence, Germ Stories
2007
Box 12
DNAX: Staffing-Eugenics
1984
Box 13
Grant files (?) 007581 Revision
2005
Box 14
Course files (including some slides)-Biochem 202 May 1980
Box 14
General Files-Spyros-A; department files; course
Box 14
Alphabetical through Ishige 2003
Box 15
Science & Society-Hargittai
Box 16
Alpha sequence: Affymetrix-Zyomyx
Box 17
Presentations Jan. 2002-Jan. 2005
Box 17
Dean Search File 1964 [CONFIDENTIAL]
Box 17
Jardetsky appointment [CONFIDENTIAL]
Box 17
Slides/illustrations-Gene A Rep
Box 18
Presentations Jan. 2000-2001
Box 19
Department 1991 [folder with minutes, memos, financial statements, etc.]
Box 19
Department 1992 [folder with minutes, memos, financial statements, etc.]
Box 19
Binder: book reviews of Kornberg's Golden Helix
Box 19
Bound volume: Collected reprints 1941-1954
Box 19
Bound volume: Reprints 1953-57 Dept. of Microbiology Washington University [Kornberg and other authors]
Box 19
Bound volume: Reprints 1958-59 Dept. of Microbiology Washington University & 1959-60 Stanford University [Kornberg and other
authors]
Box 19
Bound volume: Reprints of the Section on Enzymes and Metabolism, National Institute of Arthritis and Metabolic Diseases, NIH,
1948-52
Box 19
Binder: slides of text, graphs, charts, and specimens 1973-75 and undated
Box 20
Biochemistry 294
Winter 1992
Box 20
Department 1990 [folder with minutes, memos, financial statements, etc.]
Box 20
Table 2 Students trained by each faculty member [covers training period of the 1960s-1980s]
Box 20
Slides of text, graphs, charts, and specimens-5 binders and one stack
Box 20
Tube containing award certificate from city of Osaka, Japan (with English translation) 2004
Box 23
Correspondence, chronological
Box 24
Correspondence, chronological
Box 25
Correspondence, chronological
Box 26
Correspondence, chronological
Box 27
Correspondence, chronological
Box 28
Correspondence, chronological
Box 29
Correspondence, chronological
Box 30
Correspondence, chronological
Accession ARCH-2002-186
Additional Material
Box 1
Correspondence file re book DNA Sequencing
1973-76
Box 1
Letters of recommendation
1980-88
Box 1
Trip files
1996, 1997 Jan.-Mar
Box 1
Notes of graduate student James Flynn on biochemistry, mathematics and physics
Box 2
Trip files
Apr.-Dec. 1997
Box 2
Annual Review Article,
10/22/1998
Box 2
File re several publications
1997-98
Box 2
Transcript of UC-Berkeley oral history with Kornberg (1997)
Box 2
Transcripts from Du Pont trial (Du Pont v Cetus regarding patents) 1989-91, v. 1-4
Box 3
Transcripts from Du Pont trial 1991, v. 5-17
Box 3
Additional materials re Du Pont trial, 1989-81 (correspondence, copies of articles, etc.)
Box 4
Transcripts from Du Pont trial 1991, v. 18-21
Box 4
Other transcripts/documents from trial 1990
Box 4
"For the Love of Enzymes," typescript
Box 4
"For the Love of Enzymes," correspondence
1989-93
Box 4
"For the Love of Enzymes," letters and reviews
1989-91
Box 4
Khorana, Dr. H. Gobind – correspondence
1955-68
Box 4
Medical school 1938: biochemistry class notes
Box 4
"A Kennedy Plan" 12/7/60 [one page re development in Latin America of medical research institutes]
Box 4
Photograph and neg of Kornberg portrait
Box 4
DNA polymerase mechanism – notes, illustrations, correspondence, articles, 1969-71
Box 4
DNA duplication, DNA polymerase – assorted articles, clippings, 1954-73
Box 4
DNA duplication, DNA polymerase – correspondence, notes, charts, 1955-72
Box 4
Washington University, Dept of Microbiology – exams and miscellany, 1958-60
Box 4
Szilard, Leo, – letter and petition in response to invasion of Cuba
1961
Box 4
Sherberg, Esther, letter, 1958
Box 4
Kornberg – discharge from U.S. Public Health Service
1953
Box 4
Kornberg – press release and c.v.,
1959
Box 5
Weizmann Institute – Bay Area
Box 5
Stanford Correspondence
1973-86
Box 5
DNA Replication – update 1981 (correspondence)
Box 5
DNA Replication – requests for figure permission
Box 5
DNA Replication – figure permissions
Box 5
"For the Love of Enzymes," preliminary work, interviews, comments and communications
Box 5
"For the Love of Enzymes," draft
Box 5
"For the Love of Enzymes," image (color transparency)
Box 5
Berk Foundation Awards Dinners, programs
Box 5
Kornberg's diaries (calendars)
1966/67-2001
Box 6
Figure plates for DNA Replication and other publications
Box 7
Assorted publications, mostly biographical re Kornberg
Box 7
"Scientists' Lounge" with A. Kornberg and Dr. Osamm Hayaishi; unlabelled
1971 Apr 12
Physical Description:
2 audiotape(s) (reel-to-reel)
Box 8
Certificates, programs, calendars featuring Kornberg, galleys of For the Love of Enzymes, and two plaques
Box MC
1. Hearts and Minds The Life and Science of Alejandro Zaffaroni
Box MC
2. "Mechanisms of E. Coli DNA Replication" – Basic Sciences Research Coloquia – Stanford University School of Medicine, Oct.
20, 1983
Box MC
3. Buzz Baldwin Symposium, Berkeley, July 30, 1998
Box MC
4. Book jacket (2 copies) for Kornberg's For the Love of Enzymes
Box MC
5. Vedua di S. Gimignano [old map reproduction] signed by 21 people "To Arthur Kornberg with affection"
Box MC
6. Gene Action – '95 In Appreciation of Charley [Yanofsky], Asilomar, April 1995. (2 copies plus letter and list of attendees)
Box MC
7. I. Robert Lehman Symposium Seventieth Year 1994
Box MC
8. The Nobel Prize in Physiology or Medicine 1995. Edward B. Lewis, Christine Nusslein-Volhard, Eric F. Wieschaus.
Box MC
9. 1979 Silliman Memorial Lectures by Arthur Kornberg
Accession ARCH-2007-322
Profiles in Science images and metadata
2007 Sep 14
Profiles in Science images and metadata, 2007 Sep 14
Physical Description:
400 megabyte(s)
Physical Description:
(321 computer files in 4 directories)
Scope and Content Note
As part of its Profiles in Science project, the National Library of Medicine has collaborated with Stanford University Libraries
Department of Special Collections and University Archives to digitize and make available over the World Wide Web a selection
of the Arthur Kornberg Papers for use by educators and researchers. This site provides access to the portions of the Arthur
Kornberg Papers of Stanford University Libraries Department of Special Collections and University Archives that have been
selected for digitization. Individuals interested in conducting research in the Arthur Kornberg Papers are invited to contact
Stanford University Libraries Department of Special Collections and University Archives.
WHBBBB
[Notes on bile pigments]
6/7/1939
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
For several years in medical school, Kornberg developed an interest in bile pigments and benign jaundice, and conducted a
small study on the incidence of Gilbert's disease among medical students. The resulting publication would lead to a research
job at the National Institutes of Health in 1942.; Item is handwritten.
WHBBBC
Draft memorandum from Arthur Kornberg to Floyd S. Daft regarding fellowship questionnaires
circa 1948
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
This memo to his NIH section chief, Floyd Daft, detailed Kornberg's criteria for awarding postdoctoral fellowships.; Item
is handwritten.
WHBBBD
Letter from Arthur Kornberg to Fritz Lipmann
5/12/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to biochemist Fritz Lipmann, Kornberg provided details about the enzyme he had purified for splitting DPN (diphosphopyridine
nucleotide).
WHBBBF
Letter from Arthur Kornberg to Alan Mehler
2/21/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
This letter to his friend Alan Mehler discussed the difficulties involved in Kornberg's ongoing studies of metabolic enzymes,
and also mentioned the visit of the eminent German biochemist Otto Warburg.
WHBBBG
Letter from Arthur Kornberg to Edwin G. Kreb
2/17/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to his friend and prospective colleague Edwin Kreb, Kornberg described the benefits of working at NIH, as well
as his feelings about the changes that were occurring there at the time, such as the building of the new Clinical Center.
WHBBBH
Letter from Arthur Kornberg to Severo Ochoa
1/24/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to his former mentor Severo Ochoa, Kornberg discussed the various challenges involved with using different
yeast cultures as sources for enzymes.
WHBBBJ
Letter from Arthur Kornberg to Severo Ochoa
12/31/1948
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to his former mentor Severo Ochoa, Kornberg asked if Ochoa could return some Zwischenferment (the enzyme glucose-6-phosphate
dehydrogenase) Kornberg had sent him, as the most recent batch wasn't proving as useful for their current experiments. He
also reported feeling rather discouraged with the slow progress of his work on metabolic coenzymes.
WHBBBK
Letter from Arthur Kornberg to Kenneth E. Holt
12/23/1948
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Kornberg and other enzymologists were aided in their work by researchers at the Anheuser-Busch brewery, who provided supplies
of "cleaned" yeast for use as enzyme sources, as illustrated by this letter.
WHBBBL
Letter from Arthur Kornberg to J. Oliver Lampen
10/15/1948
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Biologists and biochemists during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their
labs, as there was often no other source. In this letter to J. O. Lampen, a friend from his time at the Cori lab, Kornberg
regretted that he had no ready supplies of nicotinamide derivatives to send, and also discussed his current experiments.
WHBBBM
Letter from Arthur Kornberg to Carl F. Cori
10/6/1948
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to his former mentor Carl Cori, Kornberg described his recent success with a new enzyme, and some insights
about the role of inorganic pyrophosphate in metabolic processes, and asked Cori to review the report he was preparing on
this work.
WHBBBN
Letter from G. A. LePage to Arthur Kornberg
11/30/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Kornberg had earlier requested information from G. A. LePage about his new method for preparing TPN (triphosphopyridine nucleotide),
but the product he made using the method was not satisfactory. In this letter, LePage discussed possible reasons for Kornberg's
problems with the process.
WHBBBP
Letter from G. A. LePage to Arthur Kornberg
5/10/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Interested in using TPN (triphosphopyridine nucleotide) for his next series of enzyme studies, Kornberg had written to G.
A. LePage for information about his new method for preparing TPN. In this response, LePage detailed the equipment and supplies
Kornberg's lab would need to make TPN.
WHBBBS
Letter from Arthur Kornberg to Alex B. Novikoff
5/23/1951
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter, Kornberg responded to Novikoff's request for information about preparation of Zwischenferment (the enzyme
glucose-6-phosphate dehydrogenase) and samples to begin the process.
WHBBBT
Letter from Alex B. Novikoff to Arthur Kornberg
5/8/1951
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter, biochemist Alex Novikoff asked Kornberg for information about preparing Zwischenferment (the enzyme glucose-6-phosphate
dehydrogenase) and several other substances needed for the process.
WHBBBV
Letter from Arthur Kornberg to Herman M. Kalckar
3/21/1951
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to biochemist Herman Kalckar, Kornberg provided him with information about the NIH research grants process,
and also gave him an update on his work on nucleotide synthesis.
WHBBBX
Letter from Carl F. Cori to Arthur Kornberg
2/15/1951
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Kornberg's former mentor Carl Cori wrote to suggest another possible interpretation of a reaction involving TPN, and added
a postscript saying, "What mysterious creatures enzymes are."
WHBBBY
Letter from Arthur Kornberg to Henry A. Lardy
2/6/1951
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to biochemist Henry Lardy, Kornberg shared his recent work on the pathway of uridine triphosphate synthesis,
part of the early work that led him to nucleotide synthesis, and ultimately to DNA synthesis.
WHBBBZ
Letter from Arthur Kornberg to W. E. Cohn
1/17/1951
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter, Kornberg congratulated biochemist Waldo Cohn on his recent success in isolating single nucleotides from RNA,
and discussed his own recent work (closely related to Cohn's) with the nucleotide pyrophosphatase derived from potatoes.
WHBBCC
Letter from Arthur Kornberg to Robert K. Morton
11/16/1961
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Robert Morton, an Australian biochemist, had recently found that baker's yeast contained a cytochrome (a protein involved
in electron transfer in cell metabolism) with a DNA component. That DNA proved to have different base ratios than the yeast's
nuclear DNA. He had suggested that this DNA could be used in understanding nucleotide sequences, and Kornberg had been working
with some samples Morton sent, looking at their ability to prime DNA synthesis with his polymerase. In this letter, he reported
some of his findings to Morton.
WHBBCD
Letter from Arthur Kornberg to W. E. Cohn
2/24/1950
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Biologists and biochemists during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their
labs, as there was often no other source. In this letter to Waldo Cohn, Kornberg apologized for the quality of a previous
sample sent, and provided more specific information about its requirements.
WHBBCF
Letter from Arthur Kornberg to Carl F. and Gerty Cori
9/28/1950
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter to his former mentors, Carl and Gerty Cori, Kornberg thanked them for good wishes regarding his Paul-Lewis
Award, and told them of his ongoing lab work, changes at NIH, and the arrival of his third son, Kenneth.
WHBBCG
Letter from G. David Novelli to Arthur Kornberg
11/6/1950
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Biologists and biochemists during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their
labs, as there was often no other source. In this letter, biochemist G. David Novelli reported to Kornberg on his experiments
with a sample of Kornberg's nucleotide-splitting enzyme.
WHBBCH
Letter from Arthur Kornberg to G. David Novelli
11/14/1950
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter, Kornberg responded to biochemist G. David Novelli's letter describing the activity of an enzyme Kornberg had
sent him.
WHBBCK
Letter from Arthur Kornberg to the editors of the Journal of Biological Chemistry
1/29/1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCL
Letter from Arthur Kornberg to John T. Edsall
12/11/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCM
Letter from Arthur Kornberg to the editors of the Journal of Biological Chemistry
12/11/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCN
Letter from John T. Edsall to Arthur Kornberg
12/27/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCP
Letter from Paul Berg to Arthur Kornberg
7/14/1970
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCQ
Letter from Leslie E. Orgel to Arthur Kornberg
circa Aug 1969
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Includes a note from Francis Crick.; Item is handwritten.
WHBBCR
Letter from Arthur Kornberg to Leslie E. Orgel and Francis Crick
8/19/1969
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCT
Letter from Julius Marmur to Arthur Kornberg
1/28/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCV
Letter from I. Robert Lehman to Julius Marmur
2/9/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCW
Letter from H. George Mandel to Arthur Kornberg
1/7/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCX
Letter from Arthur Kornberg to H. George Mandel
1/11/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCZ
Letter from Arthur Kornberg to Andre Lwoff
10/6/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDB
Letter from Arthur Kornberg to James O. Eastland
10/7/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDD
Letter from Arthur Kornberg to Van R. Potter
7/5/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDF
Letter from Robert L. Sinsheimer to Arthur Kornberg
10/6/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDG
Letter from William F. Dove to Arthur Kornberg
9/30/1971
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDH
Letter from Arthur Kornberg to William F. Dove
10/15/1971
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDJ
Letter from William F. Dove to Arthur Kornberg
10/18/1971
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDK
Letter from Bruce Alberts to Arthur Kornberg
3/23/1971
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDL
Letter from Arthur Kornberg to Bruce Alberts
8/6/1971
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDM
Letter from Arthur Kornberg to Paul Englund
12/17/1971
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDN
Letter from Arthur Kornberg to Senator Edward M. Kennedy
3/27/1978
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is a photocopy.
WHBBDX
Letter from Arthur Kornberg to Paul N. McCloskey, Jr
8/8/1977
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDY
Letter from Arthur Kornberg to Donald S. Fredrickson
2/25/1977
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is a photocopy.
WHBBFB
Letter from Arthur Kornberg to Henry S. Kaplan
7/16/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFD
Letter from Arthur Kornberg to Robert H. Alway
6/18/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFF
Letter from Robert H. Alway to Arthur Kornberg
6/13/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFG
Letter from Henry S. Kaplan to Arthur Kornberg
6/24/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFH
Letter from Arthur Kornberg to Henry S. Kaplan
1/6/1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFK
Letter from Arthur Kornberg to Alexander Rich
3/14/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFL
Letter from Arthur Kornberg to Howard K. Schachman
11/15/1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFM
Letter from Arthur Kornberg to Robert L. Sinsheimer
12/14/1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFN
Letter from Maurice H. F. Wilkins to Arthur Kornberg
8/20/1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten.
WHBBFP
Letter from Arthur Kornberg to Maurice H. F. Wilkins
10/11/1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFQ
Letter from Arthur Kornberg to Leon A. Heppel
3/9/1955
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFR
Letter from Arthur Kornberg to John R. Van Wazar
11/4/1955
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFS
Letter from Arthur Kornberg to H. Gobind Khorana
1/10/1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFT
Letter from Robert H. Alway to Arthur Kornberg
7/1/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFV
Letter from Arthur Kornberg to Frederick E. Terman
2/6/1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGB
[Telegram invitation to a White House meeting with Lyndon Johnson]
9/30/1964
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGC
Letter from Arthur Kornberg to James A. Shannon
3/11/1968
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is a photocopy.
WHBBGD
Letter from Robert Baldwin to Arthur Kornberg
5/20/1959
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGF
Letter from Arthur Kornberg to Robert Baldwin
5/27/1959
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGG
[Biochemistry 101 exam]
1960-1961
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGH
[Biochemistry 101 exam]
1961-1962
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGJ
Letter from Arthur Kornberg to H. Gobind Khorana
2/28/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGK
Letter from Arthur Kornberg to H. Gobind Khorana
3/8/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGL
Letter from H. Gobind Khorana to Arthur Kornberg
3/18/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten.
WHBBGP
Letter from Arthur Kornberg to Robert K. Morton
10/29/1962
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Robert Morton, an Australian biochemist, had recently found that baker's yeast contained a cytochrome (a protein involved
in electron transfer in cell metabolism) with a DNA component. That DNA proved to have different base ratios than the yeast's
nuclear DNA. He had suggested that this DNA could be used in understanding nucleotide sequences, and Kornberg had been working
with some samples Morton sent, looking at their ability to prime DNA synthesis with his polymerase. In this letter, Kornberg
apologized for letting other projects delay his work on the Morton DNA.
WHBBGR
Letter from Muriel Beadle to Arthur Kornberg
1/26/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In 1966, geneticist and Nobel laureate George Beadle and his wife Muriel published a laymen's guide to genetics titled "The
Language of Life: An Introduction to the Science of Genetics." In this 1965 letter, Muriel Beadle asked Kornberg to clarify
some details of his DNA synthesis work to include in the book.
WHBBGS
Letter from Arthur Kornberg to Muriel Beadle
2/4/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In 1966, geneticist and Nobel laureate George Beadle and his wife Muriel published a laymen's guide to genetics titled "The
Language of Life: An Introduction to the Science of Genetics." In this 1965 letter, Kornberg responded to Muriel Beadle's
request for details of his DNA synthesis work to include in the book.
WHBBGT
Letter from Muriel Beadle to Arthur Kornberg
2/14/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In 1966, geneticist and Nobel laureate George Beadle and his wife Muriel published a laymen's guide to genetics titled "The
Language of Life: An Introduction to the Science of Genetics." In an earlier letter, Muriel Beadle had asked Kornberg to clarify
some details of his DNA synthesis work to include in the book. In this letter, she attached a chapter draft incorporating
his response.; Item is handwritten.
WHBBGV
[Chapter 19, p. 219]
circa Feb 1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Muriel Beadle sent Kornberg this manuscript insert for Chapter 19 of "The Language of Life: An Introduction to the Science
of Genetics," after incorporating some details on his DNA synthesis work. Co-authored by geneticist George Beadle, the book
was published in 1966.
WHBBGW
Letter from Arthur Kornberg to D. S. Fahrney
1/14/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Like many acclaimed scientists, Kornberg was keenly aware that scientific merit was not the sole basis for awards and other
honors. He made this clear when asked to recommend others for awards, as in this letter regarding Marshall Nirenberg, who
would win a Nobel Prize in 1968 for his work on the genetic code.
WHBBGY
Letter from Arthur Kornberg to Allan Hauck
5/27/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
As a Nobel laureate, Kornberg often received requests for his opinions on philosophical questions. He responded with concise
and thoughtful answers, as illustrated by his letter to philosophy professor Allan Hauck.
WHBBGZ
Letter from Arthur Kornberg to Robert L. Sinsheimer
7/9/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Working to synthesize a viable DNA, Kornberg turned to the small bacterial viruses M13 and Phi X174. Biophysicist Robert Sinsheimer
at the California Institute of Technology had found that the single-stranded, circular Phi X174 virus DNA was converted to
a double helix after entering its E. coli host, and the double stranded form was by itself infective. In this letter, Kornberg
asked for a sample of Sinsheimer's virus to start investigating its possible use as a replication template. It was from this
virus that Kornberg was able to create an infective synthetic viral DNA in 1967.
WHBBHB
Letter from Arthur Kornberg to Robert L. Sinsheimer
7/29/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Working to synthesize a viable DNA, Kornberg turned to the small bacterial viruses M13 and Phi X174. Biophysicist Robert Sinsheimer
at the California Institute of Technology had found that the single-stranded, circular Phi X174 virus DNA was converted to
a double helix after entering its E. coli host, and by itself was infective. In a previous letter, Kornberg had asked for
a sample of Sinsheimer's virus to start investigating its possible use as a replication template. This letter reported on
his initial results with the virus. It was from this virus that Kornberg was able to create an infective synthetic viral DNA
in 1967.
WHBBHC
Letter from Arthur Kornberg to Henry M. Sobell
4/22/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In their work with DNA polymerase, Kornberg and his colleagues had found that it could induce a seemingly spontaneous synthesis
of an adenine-thymine polymer, without a template. This phenomenon raised a number of questions about the nature of chemical
bonds in nucleotides and nucleic acids, and the exact mechanism of the polymerase. In this letter, Kornberg responded to Henry
Sobell's research proposal on this topic.
WHBBHD
Letter from Henry M. Sobell to Arthur Kornberg
12/31/1964
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In their work with DNA polymerase, Kornberg and his colleagues had found that it could induce a seemingly spontaneous synthesis
of an adenine-thymine polymer, without a template. This phenomenon raised a number of questions about the nature of chemical
bonds in nucleotides and nucleic acids, and the exact mechanism of the polymerase. In this letter, Henry Sobell asked Kornberg
about the feasibility of approaching some of these problems via crystallographic studies and included his research proposal
on this topic.
WHBBHF
Letter from Arthur Kornberg to George Streisinger
2/2/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Geneticist George Streisinger was a noted expert on the bacterial virus (phage) T4. In this letter, Kornberg asked him if
there might be a mutant strain of T4 suitable for studying DNA synthesis in infected E. coli cells, noting that regular T4
produced so much lysozyme that the host cells were too fragile to harvest.
WHBBHG
Letter from George Streisinger to Arthur Kornberg
2/9/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Geneticist George Streisinger was a noted expert on the bacterial virus (phage) T4, and Kornberg had written to ask him if
there might be a mutant strain of T4 suitable for studying DNA synthesis in infected E. coli cells. In this letter, Streisinger
explained that such a mutant had been isolated and provided detailed instructions for preparing cultures.
WHBBHH
The Chemical Basis of Heredity
10/17/1961
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this lecture given to an audience of non-scientists, Kornberg demonstrated his talent for making complex topics accessible,
and provided a look at the state of the art in molecular biology in 1961.
WHBBHJ
[National Cancer Conference presentation (Philadelphia)]
1964-9
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this presentation at the 1964 National Cancer Conference, Kornberg discussed how molecular biology research, though a "poverty
pocket" in the academic world, might soon improve our knowledge of how genes function, and how things go wrong in genetic
processes.
WHBBHL
An Understanding of Life on a Molecular Basis
4-Feb-65
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In 1965, Kornberg participated in a lecture series titled "Science--A Challenge to Man's Faith." His presentation discussed
the current state of scientific knowledge about inheritance and evolution, the evolution of scientific thought itself, and
the role of science as a guide to behavior. Finally, he reflected on the spiritual aspects of the pursuit of knowledge.
WHBBHN
Basic Motives of a Professional Life
1969-7
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Kornberg was trained as a physician before he found his calling in biochemistry, and remained close to medical schools and
medical problems throughout his career. In this article, he reflected on three basic motives of a professional life, as applied
to careers in medicine and science.
WHBBHP
Ebb Tide in Medical Research
9/22/1970
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
As a researcher who experienced firsthand the immense growth of federal support for scientific research after 1940, Kornberg
was troubled by deep research budget cuts during the Nixon administration. As he noted in this essay, scientific research
was increasingly important to society, but like anything else, needed advocates to keep the public--and their representatives
in government--aware of its value.; Based on remarks made at the Markle Scholars' Meeting.
WHBBHQ
Letter from Arthur Kornberg and David S. Hogness to Newton Steward
10/23/1972
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
During the 1960s, the California State Department of Education had been increasingly pressured by religious groups to include
Creation Theory in science textbooks used in the public schools. In 1972, Kornberg and his colleague David Hogness asked to
address the Department on this matter, and explained why they believed that including Creation Theory would be bad for science
education (and would make Californians the "laughing stock of the entire civilized world"). After hearings in 1972, the Department
of Education decided not to require Creation Theory in science textbooks or curricula.; Item is a photocopy.
WHBBHR
Letter from Arthur Kornberg to Edward Dempsey
10/30/1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBHT
Letter from Arthur Kornberg to Salvador E. Luria
3/14/1961
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBMN
Letter from Arthur Kornberg to Avram Goldstein
7/16/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBMP
[Lab notebook 33, 1957-1958 (excerpt 1)]
30 August - 18 September 1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMQ
[Lab notebook 33, 1957-1958 (excerpt 2)]
20 September - 1 October 1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMR
[Lab notebook 28, 1956 (excerpt 1)]
18-20 July 1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMS
[Lab notebook 28, 1956 (excerpt 2)]
30-Aug-56
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMT
[Lab notebook 28, 1956 (excerpt 3)]
6-7 September 1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMV
[Lab notebook 28, 1956 (excerpt 4)]
22-25 September 1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMW
[Lab notebook 28, 1956 (excerpt 5)]
19-Sep-56
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMX
[Lab notebook 28, 1956 (excerpt 6)]
4-8 October 1956
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten. Item is a photocopy.
WHBBMZ
[Lab notes on Morton DNA]
6/13/1961
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is handwritten.
WHBBBW
Letter from W. E. Cohn to Arthur Kornberg
3/15/1951
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Biochemist Waldo Cohn had taught Kornberg the powerful technique of ion exchange chromatography in 1949. In this letter, he
responded to Kornberg's recent work on the likely configuration of the nucleotides he was then studying.
WHBBDP
Letter from Senator Edward M. Kennedy to Arthur Kornberg
1/31/1978
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDQ
[Fact sheet on federal research funding]
19-Jan-78
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Part of a package for participants in Senate hearings on 19 January 1978.
WHBBDR
Issues to be Addressed by Scientists with Government
19-Jan-78
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Part of a package for participants in Senate hearings on 19 January 1978.
WHBBDS
Goals of the Scientific Delegation
19-Jan-78
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Part of a package for participants in Senate hearings on 19 January 1978.
WHBBDW
Backgrounder on Recombinant DNA Research
7/20/1977
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFJ
Letter from Alexander Rich to Arthur Kornberg
3/8/1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBHM
Hearings on the Human Impact of Advance in Biological Science [Testimony to Senate Subcommittee on Government Research]
3/8/1968
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
The success of Kornberg and others in creating synthetic copies of DNA and RNA had provoked public concern about the future
consequences of genetic engineering, even before recombinant DNA technology was developed in the 1970s. In March 1968, Kornberg
and other leading researchers in the field testified before the Senate Subcommittee on Government Research to address these
concerns. Kornberg explained the current state of knowledge in molecular biology, the immense potential for medical applications,
and the need for much more federal funding for this branch of research.
WHBBHS
Letter from Joshua Lederberg to Arthur Kornberg
1/27/1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBBQ
Letter from Severo Ochoa to Arthur Kornberg
3/29/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter, Kornberg's former mentor Severo Ochoa thanked him for a sample of TPN (triphosphopyridine nucleotide) and
discussed his ongoing work on citrate synthesis.
WHBBBR
Letter from Severo Ochoa to Arthur Kornberg
1/3/1949
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In this letter, Kornberg's former mentor Severo Ochoa discussed his current work with biotin and its possible role in metabolism.
WHBBDZ
[Map of Stanford University Campus]
circa 1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFC
[Architect's model of new Stanford Medical Center]
1957
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFW
[Construction of Edwards Building, Stanford Medical School]
circa 1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFX
[Construction of hospital wing, Stanford Medical School]
circa 1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFY
[Construction of Lane Medical Library, Stanford Medical School]
circa 1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBFZ
[Construction of Clinic Building, Stanford Medical School]
circa 1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGQ
Letter from Severo Ochoa to Arthur Kornberg
5/11/1962
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCB
Letter from Robert K. Morton to Arthur Kornberg
11/29/1961
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Biologists and biochemists during the 1940s and 1950s frequently shared their supplies of enzymes and other products of their
labs, as there was often no other source. Here Robert Morton responded to Kornberg's report, sent several weeks earlier.
WHBBCJ
Letter from the editors of the Journal of Biological Chemistry to Arthur Kornberg
1/24/1958
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCS
Letter from Francis Crick to Arthur Kornberg
5/10/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBCY
Letter from Andre Lwoff to Arthur Kornberg
9/27/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDC
Letter from Van R. Potter to Arthur Kornberg
5/18/1960
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBDT
DNA Synthesizer Says Fear of Unknown Hurts Research
9/10/1969
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Item is a photocopy.
WHBBDV
Creator of DNA Scores Talk of 'Biological Bomb'
1/6/1972
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
WHBBGM
Letter from Francis Crick to Arthur Kornberg
10/17/1959
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
Writing to congratulate Kornberg on receiving a Nobel Prize, Francis Crick also provided an update on the current work of
his colleagues Max Perutz and John Kendrew. In 1962, Perutz and Kendrew would share the Nobel Prize in Chemistry for their
work on the structures of proteins such as hemoglobin and myoglobin; Crick would share the Nobel Prize in Medicine or Physiology
with James Watson and Maurice Wilkins, for the discovery of the structure of DNA.; Item is handwritten.
WHBBGX
Letter from Allan Hauck to Arthur Kornberg
4/27/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
As a Nobel laureate, Kornberg often received requests for his opinions on philosophical questions, as illustrated by this
letter from philosophy professor Allan Hauck.
WHBBHK
Letter from Peter M. Brown to Arthur Kornberg
1/12/1965
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note
In 1965, Kornberg participated in a lecture series titled "Science--A Challenge to Man's Faith." His presentation discussed
the current state of scientific knowledge about inheritance and evolution, the evolution of scientific thought itself, and
the role of science as a guide to behavior. Finally, he reflected on the spiritual aspects of the pursuit of knowledge.
WHBBNB
Letter from Robert K. Morton to Arthur Kornberg
7/14/1961
Physical Description:
1 computer file(s) (TIFF)
Scope and Content Note