Robert N. Hamburger Papers

Special Collections & Archives, UC San Diego
Special Collections & Archives, UC San Diego
Copyright 2005
9500 Gilman Drive
La Jolla 92093-0175
spcoll@ucsd.edu


Descriptive Summary

Languages: English
Contributing Institution: Special Collections & Archives, UC San Diego
9500 Gilman Drive
La Jolla 92093-0175
Title: Robert N. Hamburger Papers
Identifier/Call Number: MSS 0232
Physical Description: 16 Linear feet (41 archives boxes)
Date (inclusive): 1950-1992
Abstract: Papers of Robert N. Hamburger, UCSD professor of pediatrics and researcher in allergy and immunology. Hamburger investigated the relationship between peptides and immunoglobulin E (IgE) antibodies and synthesized human IgE pentapeptide (HEPP), a substance shown to inhibit allergic response. Included in the collection are laboratory notebooks (1960-1984), extensive research files on Hamburger's allergy studies, correspondence, and Food and Drug Administration documents related to animal and human testing. Also included are business files related to Allergy Peptide Company, Inc. (APCo, Inc.); Cytotech, Inc.; Immunetech, Inc.; Immunetech Research Partners; and Syntex Corporation, biotechnology firms that attempted to develop HEPP as a commercial product. The collection also contains biographical materials, writings, lectures, correspondence, and materials related to Hamburger's involvement in professional organizations. The later accessions include UCSD administrative documents including committtee materials and documents related to the history of the School of Medicine.

Scope and Content of Collection

The Robert Hamburger Papers document allergy and immunology research in Hamburger's laboratory at UCSD and the development of human IgE pentapeptide (HEPP). The collection contains laboratory notebooks (1960-1984), research materials on Hamburger's peptide studies, FDA documents, patent and grant material, and writings by Hamburger and others. Also included are business records and agreements with: APCo, Inc.; Cytotech, Inc.; Immunetech, Inc.; Immunetech Research Partners; Enterprise Management Company; and Syntex Corporation, biotechnology firms associated with the development of HEPP. Other materials include UCSD administrative files and development documents for the School of Medicine.
SERIES 1: BIOGRAPHICAL MATERIAL
The BIOGRAPHICAL MATERIAL series contains directory entries, Hamburger's curriculum vitae, news clippings, photographs, correspondence from his sabbatical leave at Guys Hospital, London, a journal of medical notes from Strong Memorial Hospital, and material from Yale University's 25th Class Reunion Symposium .
SERIES 2: RESEARCH MATERIAL
The RESEARCH MATERIAL series constitutes the bulk of the collection and is arranged in four subseries: A) Laboratory Notebooks, B) Laboratory Subject Files, C) Patent Files, and D) Grant Files.
A) The Laboratory Notebooks subseries contains laboratory research data compiled at UCSD by Hamburger, his colleagues and graduate students from 1960-1984. The notebooks contain lupus studies, immune kill studies, immunoglobulin E (IgE) and diphtheria assays, lymphocyte transformation studies, and peptide research data. The notebooks are arranged chronologically. The majority of notebooks in this series contain medical records and are restricted.
B) The Laboratory Subject Files (1962-1989) subseries contains laboratory notes, general laboratory correspondence, FDA correspondence, and FDA documents. Research contained in this subseries was conducted primarily at UCSD; however, some clinical trials where carried out at other institutions and, in some cases, sponsored by private firms including APCo, Inc., Immunetech, Inc., and the Schering Corporation. The majority of data in this subseries consists of peptide studies and HEPP (human IgE pentapeptide) trials on animals and humans, including subcutaneous testing, toxicology tests, ophthalmic solution testing, and intranasal solution tests. Other studies include Albuterol research, diphtheria-tetanus tests and a twin study. The files are arranged chronologically.
C) The Patent Files subseries is arranged chronologically and contains patent-related correspondence (1974-1986), agreements between the University of California and APCo, Inc., and drafts of Hamburger's two patents entitled "Polypeptide Agents for Blocking the Human Allergic Response" (1976) and "Method for Blocking Allergic Response" (1979).
D) The Grant Files subseries contains documentation of research grants from the National Institutes of Health (1962-1979) and the University of California, San Diego (1965 and 1977). Also included is one unfunded grant proposal to the American Cancer Society (1969).
SERIES 3: WRITINGS BY HAMBURGER
This series, which includes a bibliography of Hamburger's writings, is arranged in three subseries: A) Abstracts and Reprints, B) Talks and Lectures and C) Book Reviews for Journals.
A) The Abstracts and Reprints subseries is arranged alphabetically by title and contains materials dated 1950-1986. Included are draft chapters 1-10 of an unpublished book entitled "Pediatric Immunology and Allergy" and writings on passive immune kill, immunoglobulin E (IgE) and other immunology and allergy-related topics.
B) The Talks and Lectures subseries is arranged alphabetically by title and contains materials dated 1965-1983. Presented at various meetings and classes, materials include manuscript drafts, typescripts, lists of slides, and some correspondence. Lecture topics include immunoglobulin E (IgE), human IgE pentapeptide (HEPP) and other research associated with allergy and immunology.
C) The Book Reviews for Journals subseries is arranged alphabetically by title of journal and contains book reviews by Hamburger for Annals of Allergy, Journal of Allergy and Clinical Immunology, Journal of Laboratory and Clinical Medicine, and Science. Materials in this series, which include correspondence, are dated 1977-1985. SERIES 4: WRITINGS OF OTHERS
This series is arranged alphabetically by author and includes writings by other authors that Hamburger annotated.
SERIES 5: BIOTECHNOLOGY DEVELOPMENT FIRMS
This series documents the participation of biotechnology and investment firms in developing HEPP as a commercial product and is arranged in six subseries: A) APCo. Inc. (Allergy Peptide Company, Inc.); B) Cytotech, Inc.; C) McKewon and Timmons Investment Bankers; D) Immunetech, Inc.; E) Immunetech Research Partners; and, F) Syntex Corporation.
A) The APCo, Inc. (Allergy Peptide Company, Inc.), subseries is arranged alphabetically and contains business documents and correspondence from its establishment in 1978 by Robert Hamburger through its dissolution in 1982. For APCo, Inc., sponsored research studies see Series 2. RESEARCH MATERIAL.
B) Cytotech, Inc., is arranged alphabetically and contains Hamburger's consulting and shareholder materials, including reports, business documents and correspondence dated 1981-1988.
C) McKewon and Timmons Investment Bankers is arranged alphabetically and contains correspondence and shareholder materials dated 1983-1987. Prior to McKewon and Timmons, Ray McKewon was affiliated with the Enterprise Mangement Company, which was involved in business agreements with Immunetech, Inc., and Immunetech Research Partners. Those materials are located in the following two subseries.
D) Immunetech, Inc., is arranged alphabetically and contains business agreements, correspondence, financial reports, meeting agendas, meeting minutes, and shareholder materials dated 1976-1992. Materials dated 1981 to 1985 reflect Hamburger's primary involvment with this company, including its establishment and initial business negotiations. For Immunetech, Inc., sponsored research studies see Series 2. RESEARCH MATERIAL.
E) Immunetech Research Partners is arranged alphabetically and contains business agreements and shareholder materials dated 1981-1982. Most of these materials document the first year of this partnership (1981) between Robert Hamburger, Richard O'Connor and Gary Hahn.
F) Syntex Corporation is arranged alphabetically and contains a consulting agreement with Hamburger, a license agreement with the University of California Regents and a press release regarding the company, all of which are dated 1976. For Syntex Corporation sponsored research studies see Series 2. RESEARCH MATERIAL.
SERIES 6: PROFESSIONAL ORGANIZATIONS
Arranged alphabetically, this series contains correspondence, committee rosters and meeting materials for professional organizations in which Hamburger participated. Among the organizations represented are: the American Academy of Allergy and Immunology; the American Academy of Pediatrics; the American College of Allergy and Immunology; the California Medical Association; the Nuffield Foundation; the San Diego County Medical Society; and, the Western Society for Pediatric Research.
SERIES 7: UCSD GENERAL CAMPUS
The UCSD GENERAL CAMPUS files are documents pertaining to subjects relating to the administration of the campus and how they relate to the School of Medicine. Subjects include building of the campus, development of academic programs, the activities of individual departments and institutes, and committees Hamburger participated in, at the campus and systemwide levels. The files are arranged alphabetically.
The series also includes Hamburger's files on the UCSD Chamber Music Series. The files, labeled "Quartet Series," detail Hamburger's involvement in beginning, planning, and supporting the series. Materials include correspondence, programs, notes, planning documents, tickets, and clippings for the series that has evolved into UCSD's ArtPower! Chamber Music Series.
SERIES 8: UCSD SCHOOL OF MEDICINE
The materials of the UCSD SCHOOL OF MEDICINE, arranged alphabetically, are administrative and developmental files documenting Hamburger's involvement with committees, curriculum, residency training, and the Basic Medical Sciences building advisement. Included are several folders pertaining to the history of the school of medicine with interviews, events, and planning.
SERIES 9: ORIGINS OF THE SCHOOL OF MEDICINE AT UCSD
Documents include the correspondence and typescripts for the UCSD School of Medicine memoir, Origins of the School of Medicine at UCSD , written by Robert Hamburger and the one day symposium (November 1, 1984) transcript drafts and correspondence. The personalized history document honored both the 25th Anniversary of the founding of UCSD and the 20th Anniversary of the School of Medicine. Participants of the symposium included Herbert York, Clark Kerr, Roger Revelle, John Galbraith, Robert Hamburger, and Joseph Stokes.

Biography

Robert N. Hamburger was born in New York on January 26, 1923. He received his B.A. in zoology and chemistry in 1947 from the University of North Carolina and attended Yale University School of Medicine (1947-1951), where he conducted research on LE cells. Hamburger carried out his medical residency at Strong Memorial Hospital in Rochester, N.Y., and Yale University School of Medicine. Between 1960 and 1963, as a Special Fellow of the National Institutes of Health, he studied molecular genetics and immunology in the UCSD Department of Biology. In 1964, he was appointed associate professor of pediatrics at the UCSD School of Medicine and served as its Assistant Dean for Faculty and Curriculum Affairs (1964-1969). In 1967, during a six-month semi-sabbatical at Guy's Hospital Medical School, London, he studied the development of immunologic systems in the human newborn. Hamburger was appointed head of the Pediatric Immunology and Allergy Division of the UCSD School of Medicine in 1969.
Hamburger's laboratory research with immunoglobin E (IgE) during the early 1970s led to the synthesis of a peptide, human immunoglobin E pentapeptide (HEPP), that inhibited allergic reaction in a limited "in vivo" test. He published his findings in an article in Science (August 1, 1975) entitled "Peptide Inhibition of the Prausnitz-Kustner Reaction." The University of California obtained two patents for HEPP: "Polypeptide Agents for Blocking the Human Allergic Response" (1976) for the peptide, and "Method for Blocking Allergic Response" (1979) for a method of delivery. In March of 1977, amid optimism over HEPP's potential as a cure for allergy sufferers, Syntex Corporation, a Palo Alto biotechnology firm, bought the rights and a two year research option to develop HEPP as a product. Syntex dropped the project after a year and a half when no suitable test animal could be found to replicate human response. In 1978, Hamburger entered into an option agreement with the University of California and formed APCo, Inc. (Allergy Peptide Company, Inc.), with the purpose of advancing his research through the first stages of FDA approval.
In 1981, Hamburger and UCSD doctors Richard O'Connor and Gary Hahn formed Immunetech Research Partners to finance further stages of the peptide research. This partnership purchased the assets of APCo, Inc., including all of its research materials and, signed a research and development agreement with Immunetech, Inc., a separate company formed with venture capitalist Ray McKewon of the Enterprise Management Company. Immunetech, Inc., then purchased both UC-owned patents and attempted to develop HEPP as a product but eventually dropped the project. Hamburger was the first executive vice president of Immunetech, Inc., and was involved in research and development until 1985.
Robert Hamburger retired from UCSD in 1990 as emeritus professor and continues to conduct private research and development activities.

Publication Rights

Publication rights are held by the creator of the collection.

Preferred Citation

Robert Hamburger Papers, MSS 232. Special Collections & Archives, UC San Diego.

Acquisition Information

Acquired 1992-1993, 1996.

Restrictions

Laboratory notebooks and research files containing medical records are restricted until the year 2067. Files containing administrative files are restricted until 2084.

Subjects and Indexing Terms

Pediatricians -- United States -- Biography
Polypeptides
Peptides
Biotechnology -- Research
Biotechnology industries -- California -- San Diego County
Allergy -- Immunological aspects
Peptides -- Thereapeutic use
Peptides -- Synthesis
Peptides -- Immunology
Immunoglobulin E -- Immunology
Immunoglobulin E
Immunology -- Research -- United States
Allergy -- Treatment
Growth factors
Hamburger, Robert N. -- Archives
Cytotech, Inc.
APCo, Inc
University of California, San Diego. Department of Pediatrics
Syntex Corporation
McKewon and Timmons Investment Bankers
Immunetech, Inc
Immunetech Research Partners
University of California, San Diego -- History -- Archives
University of California, San Diego -- Faculty -- Archives

 

BIOGRAPHICAL MATERIAL

Box 1, Folder 1

Biographical materials published in various directories 1965 - 1968

Box 1, Folder 2

Committee service lists 1966 - 1968

Box 1, Folder 3

Curriculum vita 1981

Box 1, Folder 4

News clippings 1965 - 1985

Box 1, Folder 5

Photographs of Robert N. Hamburger 1975

Box 1, Folder 6-7

Sabbatical correspondence, A-Z 1967

Box 1, Folder 8

Strong Memorial Hospital journal of medical notes 1952 - 1953

Box 1, Folder 9

Yale University 25th Reunion Class Symposium 1976

 

RESEARCH MATERIAL

 

Laboratory Notebooks

Box 2, Folder 1

1960 October 23 - September 28: Workbook

Box 2, Folder 2-3

1961-1963: Auto Ab and Lupus Studies

Box 2, Folder 4-6

1962: Hela H and R Study, raw data

Box 2, Folder 7

1963 January 28 - June 18: Hela H and R Immune Kill Study, raw data - Book II

Box 2, Folder 8

1963 August 26 - 1964 May 30: Passive Immune Kill - Book III

Box 3, Folder 1

1966 February 8 - December 14: Book VIII - Robert Hamburger and J. Douglass

Conditions Governing Access note

Restrictions Apply
Box 3, Folder 2

1966 December 13 - 1967 November 7: UCSD School of Medicine - R. Hamburger and J. Douglass

Conditions Governing Access note

Restrictions Apply
Box 3, Folder 3

1967 July 1 - December 15: Book I - Robert Hamburger

Conditions Governing Access note

Restrictions Apply
Box 3, Folder 4

1968 December 19 - 1969 July 23: Antibody Binding Extracorporeal, Book I - Michael Bazaral

Box 3, Folder 5

1970 July 10 - 1972 June: Hemagglutination Assay/Thyroglobulin Immunoabsorbtion - Michael Slaughter

Conditions Governing Access note

Restrictions Apply
Box 3, Folder 6

1970 August 27 - 1971 March 4: Immunoglobin Assays - M. Bazaral, R. Hamburger and H. A. Orgel

Conditions Governing Access note

Restrictions Apply
Box 4, Folder 1

1970 December 2 - 1972: Twin Study ledger book

Conditions Governing Access note

Restrictions Apply
Box 4, Folder 2

1971 January 10 - 1973 February 2: Book 6 - Michael Bazaral

Conditions Governing Access note

Restrictions Apply
Box 4, Folder 3

1971 February 16 - October 21: Hospital Quantitative IgE Studies and Results - C. Ashcraft

Conditions Governing Access note

Restrictions Apply
Box 4, Folder 4

1971 June 17 - August 23: IgE

Conditions Governing Access note

Restrictions Apply
Box 4, Folder 5

1971 September 14 - 1972 May 4: IgE Assays I - Eva Lydick

Conditions Governing Access note

Restrictions Apply
Box 4, Folder 6

1972 January 20 - June 19: Book 3 - Eva Lydick

Conditions Governing Access note

Restrictions Apply
Box 4, Folder 7

1972 January 20 - 1977 May 31: Immunizations and Bleedings

Box 5, Folder 1

1972 February - 1973 May 30: H. Alice Orgel

Conditions Governing Access note

Restrictions Apply
Box 5, Folder 2

1972 March 14: Navy Babies/IgE Levels of Newborns - Michael Lenoir and H. Alice Orgel

Conditions Governing Access note

Restrictions Apply
Box 5, Folder 3

1972 May 10 - 1973 January 10: IgE Assays II - Eva Lydick

Conditions Governing Access note

Restrictions Apply
Box 5, Folder 4

1972 October 19 - 1973 October 30: Diphtheria Assay I

Conditions Governing Access note

Restrictions Apply
Box 5, Folder 5

1972 December 1 - 1973 March 31: Laboratory Notes - Robert Hamburger

Conditions Governing Access note

Restrictions Apply
Box 5, Folder 6

1973 January 17 - 1974 March 29: IgE Assays III - Eva Lydick

Conditions Governing Access note

Restrictions Apply
Box 5, Folder 7

1973 June 25 - 1974 March 8: Book 7 - Eva Lydick

Conditions Governing Access note

Restrictions Apply
Box 6, Folder 1

1973 October 31 - 1976 June 10: Diphtheria Assay II - Book 2

Conditions Governing Access note

Restrictions Apply
Box 6, Folder 2

1974 January 18 - 1975 June 24: Mad Scientist - Harvey Gorrin

Conditions Governing Access note

Restrictions Apply
Box 6, Folder 3

1974 March 13 - October 15: IgE Assays IV - Robert Hamburger

Conditions Governing Access note

Restrictions Apply
Box 6, Folder 4

1974 June 4 - 1975 August 14: Mason I - Donna Mason

Conditions Governing Access note

Restrictions Apply
Box 6, Folder 5

1974 July 10 - 1976 May 18: Precipitins to Milk and Precipitins to Aspergillus - Lab Book 1

Conditions Governing Access note

Restrictions Apply
Box 6, Folder 6

1974 October 21 - 1975 January 7: IgE Assay V

Box 6, Folder 7

1974 December 19 - 1975 September 2: IgE Double Ab Assay

Conditions Governing Access note

Restrictions Apply
Box 7, Folder 1

1975 January 4 - 1983 January: Immunoglobulins

Conditions Governing Access note

Restrictions Apply
Box 7, Folder 2

1975 October 7 - 1976 July 17: BSB 4033 Book II - Robert Wilcsek

Conditions Governing Access note

Restrictions Apply
Box 7, Folder 3

1976 June 1 - 1979 September 21: Milk Precipitins and Hypersensitivity Pneumonitis - Lab Book 2

Conditions Governing Access note

Restrictions Apply
Box 7, Folder 4

1976 August 26 - 1982 July 29: Pediatric Immunology and Allergy Division - D. Mason, D. Melvin and M. Wiley

Conditions Governing Access note

Restrictions Apply
Box 7, Folder 5

1976 September 29 - 1978 January 4: IgE Double Ab Assay

Conditions Governing Access note

Restrictions Apply
Box 7, Folder 6

1976 November 17 - 1977 July 14: Histamine/IgE Assays

Conditions Governing Access note

Restrictions Apply
Box 8, Folder 1

1977 January 24 - August 23: Lymphocyte Transformation Studies I - Sylvia Johnson

Conditions Governing Access note

Restrictions Apply
Box 8, Folder 2

1977 June 20 - August 22: Lymphocyte Transformation and Rosettes Patients I - Sylvia Johnson

Conditions Governing Access note

Restrictions Apply
Box 8, Folder 3

1977 June 20 - August 22: Lymphocyte Transformation and Rosettes Patients II - Sylvia Johnson

Conditions Governing Access note

Restrictions Apply
Box 8, Folder 4

1978 July 19 - 1979 March 21: Basophil Degranulation Inhibition by Pentapeptide - Bob Ziering

Conditions Governing Access note

Restrictions Apply
Box 8, Folder 5

1979 October 25 - 1980 April 30: Etiologic Role of Allergic Rhinitis in Serous Otitis Media - D. Cook, H. Ort

Conditions Governing Access note

Restrictions Apply
Box 8, Folder 6

1980 July 28 - 1985 August 2: Lymphocyte Transformation - Book IV

Conditions Governing Access note

Restrictions Apply
Box 8, Folder 7

1981 February 10 - 1982 August 10: Diphtheria Assay - Book IV

Conditions Governing Access note

Restrictions Apply
Box 9, Folder 1

1981 February 12 - 1983 March 16: Pediatric Immunology and Allergy Division - Hector Heredia

Conditions Governing Access note

Restrictions Apply
Box 9, Folder 2

1981 April 22 - November 23: Pediatric Immunology and Allergy Division/Kaiser study - Quants, IgA, M and G

Conditions Governing Access note

Restrictions Apply
Box 9, Folder 3

1981 September 12 - December 14: Peptide Research - John Bastian

Conditions Governing Access note

Restrictions Apply
Box 9, Folder 4

1981 October 13 - 1982 March 23: ISP - Diana Hu

Conditions Governing Access note

Restrictions Apply
Box 9, Folder 5

1982 July 12 - 1983 February 7: Diphtheria E.I.A

Conditions Governing Access note

Restrictions Apply
Box 9, Folder 6

1982 December 21 - 1984 September 10: Serum Free Media, Human Dagmara Tubelis

Conditions Governing Access note

Restrictions Apply
Box 9, Folder 7

1983 March 7 - May 4: Pediatric Immunology and Allergy Division, lab data - Hector Heredia

Box 10, Folder 1

1983 March 11 - June 22: Peptide Studies - Maryetta Hornbeck

Conditions Governing Access note

Restrictions Apply
Box 10, Folder 2

1983 November 7 - 1984 May 29: AIDS Study

Conditions Governing Access note

Restrictions Apply
Box 10, Folder 3

1984 January 5 - December 22: RAST Worksheets

Conditions Governing Access note

Restrictions Apply
 

Laboratory Subject Files

Box 11, Folder 1

1962: Tissue culture summary data

Box 11, Folder 2-5

1964 - 1967: Correspondence

Box 11, Folder 6

1967: Lab result photos, urea/glycine gel

Box 11, Folder 7

1968: Correspondence

Box 11, Folder 8

1970: IgE mother-baby study

Box 11, Folder 9

1970-1972: Twin study

Conditions Governing Access note

Restrictions Apply
Box 11, Folder 10

1974: Correspondence

Box 11, Folder 11

1974: Disophrol and it's components in seasonal allergic rhinitis study

Box 11, Folder 12-14

1974-1978: Albuterol studies - Schering Corporation

Box 11, Folder 15

1974-1979: Allergy in infants study

Conditions Governing Access note

Restrictions Apply
Box 11, Folder 16

1975: Correspondence - FDA

Box 11, Folder 17

1975: Correspondence - General laboratory

Box 11, Folder 18

1975: In vitro pentapeptide tests, 1-7

Box 11, Folder 19

1975: Peptide displacement experiment

Box 11, Folder 20

1975: Peptide inhibition of allergy study

Box 11, Folder 21

1975: Peptide stability study, electrophoresis strip photos - Peninsula Laboratories, Inc

Box 11, Folder 22

1975-1977: Peptide studies - Syntex Corporation

Box 11, Folder 23

1976: Correspondence - FDA

Box 11, Folder 24

1976: Correspondence - General laboratory

Box 11, Folder 25

1976: IgE low level assay

Box 11, Folder 26

1976: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R

Box 11, Folder 27

1976: Statement of investigator - Pentapeptide D-S-D-P-R

Box 12, Folder 1

1976: Thymosin in primary cellular immunodeficiencies protocol

Box 12, Folder 2

1976: Vaceril studies - Schering Corporation

Box 12, Folder 3

1976-1983: HEPP clinical studies summary, part I

Box 12, Folder 4

1976-1983: HEPP clinical studies summary, part II

Box 12, Folder 5

1977: Correspondence - FDA

Box 12, Folder 6

1977: Correspondence - General laboratory

Box 12, Folder 7

1978: Correspondence - FDA

Box 12, Folder 8

1978: FDA inspection

Box 12, Folder 9

1978: Peptides quality control records - Peninsula Laboratories, Inc

Box 12, Folder 10

1978-1979: Cyclic amp/gmp notes

Box 12, Folder 11

1978-1979: Passive immunity notes

Box 12, Folder 12

1978-1980: IgE low level studies

Box 12, Folder 13

1978-1980: Skin tests/radio allergosorbent test (RAST) results

Conditions Governing Access note

Restrictions Apply
Box 12, Folder 14

1978-1983: Human IgE pentapeptide toxicology summary

Box 12, Folder 15

1979: Correspondence - FDA

Box 12, Folder 16

1979: Correspondence - General laboratory

Box 12, Folder 17

1979: HEPP inhibition of allergy study - APCo, Inc

Box 12, Folder 18

1979: IgE PRIST studies

Box 12, Folder 19

1979: Lab notes

Box 12, Folder 20

1979: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R

Box 12, Folder 21

1979-1980: HEPP studies

Conditions Governing Access note

Restrictions Apply
Box 12, Folder 22

1979-1984: HEPP clinical study summaries

Box 12, Folder 23

1980: Amino acid electrophoresis data

Box 13, Folder 1

1980: Correspondence - FDA

Box 13, Folder 2

1980: Correspondence - General laboratory

Box 13, Folder 3

1980: FDA inspection

Box 13, Folder 4

1980: Guidelines for the evaluation of endogenous peptides and their analogs

Box 13, Folder 5

1980: IgE/radio allergosorbent test (RAST) - Kaiser study

Conditions Governing Access note

Restrictions Apply
Box 13, Folder 6

1980: Kallstad comparison data

Box 13, Folder 7

1980: Milestones document

Box 13, Folder 8

1980-1981: Enzyme immunoassay for immunoglobulin E study - CalBiochem

Box 13, Folder 9

1980-1981: Immunoradiometric assay for IgE - Hybritech, Inc

Box 13, Folder 10

1981: Correspondence - FDA

Box 13, Folder 11

1981: Correspondence - General laboratory

Box 13, Folder 12

1981: IgE research results - Hybritech, Inc

Conditions Governing Access note

Restrictions Apply
Box 13, Folder 13

1981: Peptide nomenclature

Box 13, Folder 14

1981: Research results

Conditions Governing Access note

Restrictions Apply
Box 13, Folder 15

1981-1982: Efficacy and safety comparison study of choledyl and theodur tablets - Warner Lambert/Parke Davis

Box 13, Folder 16

1981-1982: HEPP research results - UCLA Statistical/Biomathematical Consulting Center

Conditions Governing Access note

Restrictions Apply
Box 13, Folder 17-18

1981-1983: HEPP therapeutic trial (25-day, 38 patient) double-blind, randomly selected, placebo-controlled

Box 13, Folder 19

1981-1983: Intranasal toxicity test in rabbits via nasal spray - Immunetech, Inc

Box 13, Folder 20

1982: Amino acid electrophoresis data

Box 13, Folder 21

1982: Correspondence - FDA

Box 14, Folder 1

1982: Correspondence - FDA

Box 14, Folder 2

1982: Correspondence - General laboratory

Box 14, Folder 3

1982: Efficacy of HEPP protein in the treatment of allergy

Box 14, Folder 4

1982: FDA inspection

Box 14, Folder 5

1982: HEPP acute intravenous toxicity study in mice

Box 14, Folder 6-7

1982: HEPP trial (14-day, 12 patient) double-blind, dose response, placebo-controlled

Conditions Governing Access note

Restrictions Apply
Box 14, Folder 8-11

1982-1984: HEPP phase II, double-blind, randomized, placebo-controlled

Box 14, Folder 12

1982-1984: IgA and IgE research data

Box 14, Folder 13

1983: Clr = ClEs function

Box 14, Folder 14

1983: Correspondence - FDA

Box 14, Folder 15

1983: Correspondence - General laboratory

Box 15, Folder 1

1983: Diphtheria-tetanus test results

Conditions Governing Access note

Restrictions Apply
Box 15, Folder 2

1983: HEPP subacute subcutaneous toxicity study in rats

Box 15, Folder 3

1983: IgE egg research data

Box 15, Folder 4

1983: SAI inspection of toxicological testing facility

Box 15, Folder 5

1983-1984: HEPP intranasal administration, double-blind study

Box 15, Folder 6-7

1983-1984: HEPP phase II study results and phase III clinical protocol - Immunetech, Inc

Box 15, Folder 8-9

1983-1984: HEPP phase III, subcutaneous, double-blind, randomized, placebo-controlled

Box 15, Folder 10-11

1983-1986: HEPP three-year plan, volumes I & II

Box 16, Folder 1

1984: Correspondence - FDA

Box 16, Folder 2

1984: Correspondence - General laboratory

Box 16, Folder 3

1984: HEPP metabolism studies

Box 16, Folder 4

1984: HEPP rabbit teratology - Science Applications, Inc

Box 16, Folder 5

1984: HEPP rat subchronic toxicology - Science Applications, Inc

Box 16, Folder 6

1984: HEPP safety and efficacy in patients with perennial allergic rhinitis

Box 16, Folder 7

1984: HEPP USAN listing request

Box 16, Folder 8

1984: Milk-specific IgA E.I.A

Box 16, Folder 9

1984: Notice of claimed investigational exemption for a new drug - Pentapeptide D-S-D-P-R, Immunetech, Inc

Box 16, Folder 10

1984-1986: HEPP ophthalmic clinical study - Immunetech, Inc

Box 16, Folder 11

1985: Correspondence - General laboratory

Box 16, Folder 12

1985: Diphtheria-tetanus test results

Conditions Governing Access note

Restrictions Apply
Box 16, Folder 13

1985: HEPP double-blind study of the effect of 3 weeks of treatment on the nasal provocation test - Merck

Box 16, Folder 14

1985: HEPP ophthalmic solution

General note

Includes notice of claimed investigational exemption, animal toxicology results and ophthalmic solution clinical protocol - Immunetech, Inc.
Box 16, Folder 15

1985: HEPP ophthalmic solution phase II clinical results - Immunetech, Inc

Box 16, Folder 16

1985: HEPP summary of data on the efficacy and tolerance

Box 16, Folder 17

1985: Statement of investigator - Pentapeptide D-S-D-P-R

Box 16, Folder 18

1986: Clinical advantages of HEPP over conventional antiallergy drugs - Draft report

Box 16, Folder 19

1986: Correspondence - General laboratory

Box 16, Folder 20

1986: Diphtheria-tetanus test results

Conditions Governing Access note

Restrictions Apply
Box 16, Folder 21

1986: HEPP bioavailability study

Box 16, Folder 22

1986: HEPP for injection study

Box 16, Folder 23

1986: HEPP intranasal phase III study

Box 16, Folder 24

1986: HEPP ophthalmic solution dose range clinical trial summary

Box 16, Folder 25

1986: HEPP ophthalmic solution test results

Conditions Governing Access note

Restrictions Apply
Box 17, Folder 1

1989: Nasal NDA summary, clinical section - Immunetech, Inc

Box 17, Folder 2

1989: Pentyde nasal solution three week safety and efficacy study - Immunetech, Inc

Box 17, Folder 3

Undated: Mitogen stim. indexes

Conditions Governing Access note

Restrictions Apply
Box 17, Folder 4

Undated: Unidentified laboratory notes

 

Patent Files

Box 17, Folder 5

1963: Agreement with the University of California

Box 17, Folder 6

1974-1975: Correspondence

Box 17, Folder 7

1976: Correspondence

Box 17, Folder 8

1976: Polypeptide Agents for Blocking the Human Allergic Response - Patent

Box 17, Folder 9

1977: Application amendment

Box 17, Folder 10-12

1977-1979: Correspondence

Box 17, Folder 13

1979: Method for Blocking Allergic Response - Patent

Box 17, Folder 14

1979: Option agreement

General note

Agreement for APCo's commercial development of Robert Hamburger's UC-owned patent entitled: Polypeptide Agents for Blocking the Human Allergic Response.
Box 17, Folder 15

1980-1981: Correspondence

Box 17, Folder 16

1982: Agreement with the University of California

Box 17, Folder 17

1982: Correspondence

Box 17, Folder 18

1983-1986: Correspondence

 

Grant Files

Box 17, Folder 19

1962-1967: Genetics course - National Institutes of Health

Box 17, Folder 20

1964: Research grant - National Institutes of Health

Box 17, Folder 21

1964-1971: Immune Kill and Cells in Tissue Culture - National Institutes of Health

Box 18, Folder 1

1964-1971: Immune Kill and Cells in Tissue Culture - National Institutes of Health

Box 18, Folder 2

1965: Research grant - University of California, San Diego

Box 18, Folder 3

1969: Antigenic Enhancement by Foreign Haptens - American Cancer Society (not funded)

Box 18, Folder 4

1971: Genetics of Immunoglobulin E - National Institutes of Health

Box 18, Folder 5

1976-1977: Development and Genetics of IgE and Allergy - National Institutes of Health

Box 18, Folder 6

1977: Atopy and IgE Synthesis - National Institutes of Health

Box 18, Folder 7

1977: Safety and Toxicity of Synthetic IgE - University of California, San Diego

Box 18, Folder 8

1979: Biomedical Research Support Grant - National Institutes of Health

Box 18, Folder 9

Undated: Development of Immunoglobulin E - National Institutes of Health

 

WRITINGS BY ROBERT HAMBURGER

 

Abstracts and Reprints

Box 18, Folder 10

Robert Hamburger's bibliography 1950 - 1978

Box 18, Folder 11

All About Allergy Shots - Abstract 1976

Box 18, Folder 12

Allergy and the Immune System - Reprint 1976

Box 18, Folder 13

Anaphylaxis-like Reactions to Corticosteroid Therapy - Photocopy of original article 1974

Box 18, Folder 14

Antigenic Determinants on the Chloramphenicol Molecule - Abstract undated

Box 18, Folder 15

Antigenic Specifications Acquired From the Growth Medium by Cells in Tissue Culture - Reprint 1963

Box 18, Folder 16

Atmospheric Pollen and Spore Sampling in San Diego, California - Reprint 1976

Box 18, Folder 17-18

Chloramphenicol-Specific Antibody - Abstract & reprint 1966

Box 18, Folder 19

Clonal Growth of Primary Human Cell Cultures - Reprint 1964

Box 18, Folder 20

Conservation of Active Sites in Molecules with Immunoglobulin Fold Domain Structure - Reprint. (Chapter 16 of Immunologic Analysis) undated

Box 18, Folder 21

Current Status of the Clinical and Immunologic Consequences of a Prototype Allergic Disease Prevention Program - Typescript 1983

Box 18, Folder 22

Development and Inheritance of IgE and Allergy - Reprint 1974

Box 18, Folder 23

Development and Inheritance of IgE Mediated Hypersensitivity - Typescript 1978

Box 18, Folder 24

Development of Atopic Allergy in Children - Reprint 1980

Box 18, Folder 25

Development of Gamma Globulins in the Human Newborn - Abstract 1968

Box 18, Folder 26-27

Development of IgE and Allergy in Infancy - Typescript & reprint 1974

Box 18, Folder 28

Diagnosis and Prophylaxis of Atopic Allergic Diseases in the First Three Years of Life - Reprint 1979

Box 18, Folder 29

Evolutionary Relationship of Thymopoietin to Immunoglobulins and Cellular Recognition Molecules - Reprint 1981

Box 18, Folder 30

Genetics of IgE and Allergy: Serum IgE Levels in Twins - Reprint 1974

Box 18, Folder 31

IgE and Allergy - Reprint 1976

Box 18, Folder 32

IgE Levels in Normal Infants and Mothers and an Inheritance Hypothesis - Reprint 1971

Box 18, Folder 33

Immunoglobulin E in Leprosy - Abstract, undated

Box 18, Folder 34

Induction of the Lupus Erythematosus ("L.E.") Cell In Vitro in Peripheral Blood - Reprint 1950

Box 18, Folder 35

Inhibition by IgE Pentapeptide of IgE Rosette Formation by Human Basophils - Abstract 1982

Box 18, Folder 36

Inhibition of IgE Binding to Tissue Culture Cells and Leucocytes by Pentapeptide - Photocopy of original article 1979

Box 18, Folder 37

Metabolism of IgE in Transfused Infants - Abstract 1974

Box 18, Folder 38

New Experimental Approaches to the Therapy of Atopic Diseases - Galley proof & reprint 1983

Box 18, Folder 40

New Means for Serum IgE Levels Result from Changes in Measurement Methodology - Abstract 1979

Box 18, Folder 41

Newer Bronchodilators - Abstract undated

Box 18, Folder 42

Niveles de Immunoglobulina E, Herencia a la Alergia e Inmunidad a las Helmintos - Photocopy of original article 1973

Box 18, Folder 43

Of Many Things... And the Immune System - Reprint 1978

Box 18, Folder 44

Office Diagnosis of Immunodeficiency Disease - Typescript undated

Box 18, Folder 45-46

Passive Immune Kill and Pseudo-Autoimmune Disease: Proposed Model for Chloramphenicol Induced Aplastic Anemia - Correspondence 1967-1968

Box 18, Folder 47-49

Passive Immune Kill of Cells in Tissue Culture - Correspondence, reprint & typescript 1965

 

Pediatric Immunology and Allergy

Box 18, Folder 50

Chapter 1: Introduction - Draft undated

Box 18, Folder 51

Chapter 2: Human Fetal Immune System - Draft undated

Box 18, Folder 52

Chapter 3: Development of Antigen Responses in the Fetus - Draft undated

Box 19, Folder 1

Chapter 3: Reference articles

Box 19, Folder 2

Chapter 5: Development in the First Year of Life - Draft undated

Box 19, Folder 3

Chapter 5: Reference articles

Box 19, Folder 4

Chapter 6: Strategy of Immunizations - Draft undated

Box 19, Folder 5

Chapter 6: Reference articles

Box 19, Folder 6

Chapter 7: Some Genetics of the Immune System - Draft undated

Box 19, Folder 7

Chapter 7: Reference articles

Box 19, Folder 8

Chapter 8: Draft undated

Box 19, Folder 9

Chapter 8: Reference articles

Box 19, Folder 10

Chapter 9: Pages 7-9 only - Draft undated

Box 19, Folder 11

Chapter 10: Laboratory Techniques - Draft undated

Box 19, Folder 12

Correspondence 1979

Box 19, Folder 13

Peptide Inhibition of the Prausnitz-Kustner Reaction - Reprint 1975

Box 19, Folder 14

Prophylaxis of Allergy - Abstract 1976

Box 19, Folder 15

Prophylaxis of Allergy in Infants Debate - Abstract undated

Box 19, Folder 16-17

Radio Allergosorbent Test (RAST) and Skin Tests in Low IgE Individuals - Abstract & research notes for writing 1979 - 1980 & undated

Box 19, Folder 18

Recent Studies with Human IgE Pentapeptide (HEPP) - Reprint 1981

Box 19, Folder 19

Regulation and Measurement of IgE in Atopy - Typescript undated

Box 19, Folder 20-22

Results of a Double-Blind Randomly Selected Placebo-Controlled Therapeutic Trial of Human IgE Pentapeptide - Abstract undated

Box 19, Folder 23

Safety and Efficacy of Human IgE Pentapeptide - Abstract 1984

Box 19, Folder 24

Separation of Electophoretic Bands from a Bence-Jones Protein - Abstract 1968

Box 19, Folder 25

Some New Studies With Human IgE Pentapeptide (HEPP) - Abstract undated

Box 19, Folder 26

Standardization and Stability of Immunoglobulin E (IgE) - Reprint 1972

Box 19, Folder 27

Statement from UCSD to the California Senate Fact Finding Committee of Public Health and Safety - Typescript 1966

Box 19, Folder 28

Studies of Human IgE Pentapeptide: HEPP - Reprint 1980

Box 19, Folder 29-30

Transfused Immunoglobulin E in Newborns, Letter to the Editor - Photocopy of original article & typescript 1982

Box 19, Folder 31

Unidentifiable notes, figures and tables used in miscellaneous writings undated

Box 19, Folder 32

Untitled, undated writing

Box 19, Folder 33

Use of the Laboratory in the Diagnosis of Allergic Disease - Photocopy of original article 1986

Box 19, Folder 34

Value of PRIST, RAST and Skin Tests in Selected Individuals - Abstract undated

 

Talks and Lectures

Box 19, Folder 35

List of talks and lectures by Robert Hamburger 1965 - 1968

Box 19, Folder 36

Allergic Tissue Damage and Foreign Anitgens - Typescript 1969

General note

Presented at the 4th Nuffield Conference on Rheuatism, Oxfordshire, England.
Box 19, Folder 37

Allergy, Immunology and the Inheritance of IgE Levels - Typescript 1971

General note

Presented at a West Coast Allergy Society meeting.
Box 19, Folder 38

Allergy, Pathology Lecture - Handwritten introduction and list of slides for lecture 1982

Box 19, Folder 39

Allergy Physician's Assistant (APA) Training Program - Abstract 1975

General note

Presented at an American Academy of Allergy meeting.
Box 19, Folder 40

Allergy Testing for the Primary Care Physician - Typescript outline 1982

General note

Presented at the 26th Annual Symposium of the San Diego Academy of Family Physicians.
Box 19, Folder 41

Atopic Asthma - List of slides 1980

General note

Presented at a meeting in Medellin, Columbia.
Box 19, Folder 42

Atopy, Hypersensitivity or Allergy - Handwritten draft 1976

General note

Presented to Core Medical Education students.
 

Biologic Basis For a New Therapeutic Approach to Allergic Disease

Box 19, Folder 43

Abstract 1975

General note

Presented at an American Academy of Allergy meeting and the Second Charles Blackley Symposium.
Box 19, Folder 44

List of slides, undated

General note

Presented at the Second Charles Blackley Symposium.
Box 19, Folder 45

Biology of IgE - List of slides 1977

General note

Presented at Pomona College, California.
Box 19, Folder 46

Blockade of Mast Cell Receptors for the Treatment of Human Allergies - Handwritten draft 1976

General note

Presented at a Canadian Society of Allergy and Clinical Immunology meeting.
Box 19, Folder 47

Clinical Manifestations of Atopy - List of slides 1977

General note

Presented to a Pathology class.
Box 19, Folder 48

Development and Genetics of IgE and Allergy - Typescript 1976

General note

Presented at a joint meeting of the Northern California Section of the American Association of Clinical Chemists and the California Association of Bioanalysts.
Box 19, Folder 49

Development and Inheritance of IgE Mediated Hypersensitivity - List of slides 1978

General note

Presented at USC's Practical Allergy and Immunology Conference.
Box 19, Folder 50

Development of IgE and Allergy - Handwritten outline 1975

General note

Presented to biology students at Mar Vista High School, San Diego.
 

Development of IgE and Allergy During the First Year of Life: Preliminary Data

Box 19, Folder 51

Abstract 1974

General note

Presented at the 30th Annual American Academy of Allergy Meeting.
Box 19, Folder 52

Correspondence 1973 - 1974

Box 19, Folder 53

Research notes for lecture 1974

Box 19, Folder 54

Development of IgE in Infancy and Childhood - Handwritten draft 1975

General note

Presented at a West Coast Allergy Society meeting.
Box 19, Folder 55

Development of the IgE Allergy System and it's Effect on Subsequent Atopic Allergy - Typescript and slide list

General note

Undated.
Box 19, Folder 56

Developmental Immunology and Allergy in the First Two Years of Life - Handwritten draft 1975

General note

Presented at a March of Dimes sponsored event at Sunrise Hospital, Las Vegas, Nevada.
Box 19, Folder 57

Diagnostic Update in Allergy - Handwritten outline and list of slides 1977

General note

Presented at Paradise Valley Hospital, San Diego for the Core Medical Education Program.
Box 19, Folder 58

Diagnostic Value and Problems of Skin Tests, PRIST and RAST and Food Allergy - Tables used in lecture 1980

General note

Presented at a meeting in Monterrey, Mexico.
Box 19, Folder 59

Dose Response to Human IgE Pentapeptide (HEPP) - Abstract 1983

General note

Presented at the 39th Annual Congress of the American College of Allergists, New Orleans, Louisiana.
Box 20, Folder 1

Effect of Oral Albuterol on Plasma Cyclic Adenosine Monophosphate - Abstract 1975

General note

Presented at an American Academy of Allergy meeting.
Box 20, Folder 2

Experience with Carnation Hypoallergenic Formula - Typescript 1988

General note

Presented at the Food Allergy Symposium, New York.
Box 20, Folder 3

Genetics and Allergy - Typescript 1982

General note

Presented at the Southwest Allergy Symposium.
Box 20, Folder 4

IgE and Allergy - List of slides 1974

General note

Presented at the U.S. Naval Hospital, Pediatrics Department, San Diego.
Box 20, Folder 5

IgE and HEPP on the Wil-2 WT Cell (lecture 1) and Mechanism and Inheritance of Allergy (lecture 2) 1978

General note

Contains list of slides for both lectures. Presented at a meeting in Birmingham and to Core Medical Education students.
Box 20, Folder 6

IgE, Biology and Clinical Activity - List of slides 1974

General note

Presented at the U.S. Naval Hospital, Dermatology Department, San Diego.
Box 20, Folder 7

IgE Blocking Peptide - Handwritten draft 1975

General note

Presented at the San Diego Pulmonary Society Conference.
Box 20, Folder 8

IgE in Allergy - Handwritten draft and list of slides 1973

Box 20, Folder 9

IgE in Food Allergy - Typescript and photocopies of slides, undated

Box 20, Folder 10

IgE, Peptides and Allergy - Handwritten draft 1975

General note

Presented at Grand Rounds, University Hospital, San Diego.
Box 20, Folder 11

Immune Response to Chloramphenicol - Typescripts in English and Spanish, undated

Box 20, Folder 12

Immunization - Handwritten outline 1966

General note

Presented at a Peace Corp meeting.
Box 20, Folder 13

Immunodeficiency and Allergic States - Handwritten outline 1980

General note

Presented at a meeting in Acapulco.
Box 20, Folder 14

Immunologic Deficiency Disease - Handwritten outline and list of slides 1975

General note

Presented at Doctor's Hospital, San Diego.
Box 20, Folder 15

Immunology of Breast Milk and Phophylaxis of Allergy - Handwritten draft 1979

General note

Presented at the Pediatric Grand Rounds, University Hospital, San Diego.
Box 20, Folder 16

Immunotherapy - List of slides, undated

Box 20, Folder 17

Improved Screening Method for Anti-Chloramphenicol Antibodies - Abstract 1970

General note

Presented at the 17th Annual Western Society for Pediatric Research meeting, Carmel, California.
Box 20, Folder 18

Indications for Hyposensitization, Desensitization, Injection Therapy, and Immunotherapy - Handwritten outline 1974

General note

Presented at the U.S. Naval Hospital, Pediatrics Department, San Diego.
Box 20, Folder 19

International Meeting of Asthmology lecture - Typescript in English and Spanish 1974

General note

Presented at the Interasma Conference, Havana, Cuba.
Box 20, Folder 20

Is it Immune Deficiency or Just a Bad Winter? Typescript outline 1982

Box 20, Folder 21

Joseph Weiner, M.D. Memorial Lecture - Handwritten draft introduction 1983

General note

Presented at St. Raphael Hospital, Milford, Connecticut.
Box 20, Folder 22

Journal Club Lecture - Handwritten draft introduction 1966

General note

Presented at Children's Hospital of Orange County, California.
Box 20, Folder 23

Los Angeles Allergy Society Lecture - Handwritten draft introductions, 1 - 3 1975

Box 20, Folder 24

Management of Asthma - Handwritten draft 1978

General note

Presented as an American Academy of Pediatrics Core Medical Education Course, University Hospital, San Diego.
Box 20, Folder 25

More About IgE Than You'd Care to Know - Handwritten draft and list of slides 1975

Box 20, Folder 26

Once Around [the World] - Handwritten draft 1978

Box 20, Folder 27

Paramedical Aspects of Medical Treatment of Chest Diseases - Typescript 1978

General note

Presented at the Interasthma Congress.
Box 20, Folder 28

Pediatric Allergy - List of slides 1980

Box 20, Folder 29

Peptide Inhibition of Allergic Reaction - List of slides 1976

Box 20, Folder 30

Prediction, Prevention and Treatment of Allergic Asthma - Handwritten draft 1976

General note

Presented at John D. Spreckles Lodge, San Diego. Sponsored by the Lung Association of San Diego and Imperial Counties.
Box 20, Folder 31

Preparation for General Pediatrics and Sub-Specialty Training - Typescript, undated

General note

Presented at the Congresos De Pediatria, Mexico.
Box 20, Folder 32

Present and Future in Treatment of Allergic Diseases - List of slides 1980

General note

Presented at a meeting in Medellin, Colombia.
Box 20, Folder 33

Prophylaxis of Allergy in Infants Debate - Handwritten outline and list of slides 1976

General note

Presented at an immunology conference.
Box 20, Folder 34

Prophylaxis of Atopic Asthma in the First Two Years of Life - Typescript 1978

General note

Presented at the IX Interasthma Congress, New Orleans, Louisiana.
 

Pseudo-Autoimmune Disease

Box 20, Folder 35

Correspondence 1965 - 1966

Box 20, Folder 36

Typescript 1965

General note

Presented at the XI International Congress of Pediatrics, Tokyo, Japan.
Box 20, Folder 37

Radio Allergosorbent Test (RAST) - List of slides 1981

General note

Presented at the Second Annual Course on Selected Topics in Immunology, School of Medicine, University of Guadalajara.
Box 20, Folder 38

Serum Assays for Antigen Specific IgE Antibody - Handwritten introduction and list of slides 1981

General note

Presented at an American College of Allergists meeting.
Box 20, Folder 39

Sickle Cell Anemia - Handwritten outline 1969

General note

Presented at a Charles Drew Foundation meeting.
Box 20, Folder 40

T-Cell Modulation of IgE Production - Handwritten introduction and list of slides 1980

General note

Presented at a West Coast Allergy Society meeting, Acapulco.
Box 20, Folder 41

Treatments of the Future - Handwritten introduction and list of slides 1977

General note

Presented at the VII Congreso Medico Estatal, Tijuana, Mexico.
Box 20, Folder 42

UCSD Allergy in Infancy Study: An Interim Report - Typescript and list of slides 1978

General note

Presented at a West Coast Allergy Society meeting.
Box 20, Folder 43

Understanding Allergy - Handwritten draft 1976

General note

Presented at the UCSD Medical Center Auxiliary Health Education Lecture Series.
Box 20, Folder 44

Values and Problems with PRIST and RAST in Children - Abstract 1979

General note

Presented at the American Academy of Pediatrics Annual Meeting.
Box 20, Folder 45

What Can Our Friends the Animals Tell Us About IgE Mediated Disease in Humans? Handwritten draft 1975

General note

Presented at a Journal Club meeting.
Box 20, Folder 46

Where Are We and Where Are We Going in Allergy? Handwritten note cards, undated

Box 20, Folder 47-48

Untitled lectures - Handwritten drafts and typescripts 1973 - 1981

 

Book Reviews for Journals

Box 20, Folder 49

Annals of Allergy 1977 - 1985

Box 20, Folder 50

Journal of Allergy and Clinical Immunology 1979 - 1985

Box 20, Folder 51

Journal of Laboratory and Clinical Medicine 1977

Box 20, Folder 52

Science 1973

 

WRITINGS OF OTHERS

Box 20, Folder 53

List of writings of others kept on Robert Hamburger's desk, undated

Box 20, Folder 54-55

Annotated by Robert Hamburger, A - H

Box 21, Folder 1-2

Annotated by Robert Hamburger, I - V

Box 21, Folder 3

Unidentified authors

 

BIOTECHNOLOGY DEVELOPMENT FIRMS

 

APCo, Inc. (Allergy Peptide Company, Inc.)

Box 21, Folder 4

Business documents 1978 - 1982

Box 21, Folder 5

Correspondence 1981 - 1982

Box 21, Folder 6

Deed of gift to the UC Regents 1982

Box 21, Folder 7

Income tax returns 1981 - 1982

Box 21, Folder 8

Joint venture proposal from Immunoscience Corp. 1979

Box 21, Folder 9

Option agreement 1979

 

Cytotech, Inc.

Box 21, Folder 10

Amended and Restated Articles of Incorporation 1987

Box 21, Folder 11

Brochure 1983

Box 21, Folder 12

Correspondence 1982 - 1988

Box 21, Folder 13

Human complement product list 1985

Box 21, Folder 14

News clippings of Cytotech, Inc. 1984 - 1985

Box 21, Folder 15

News clippings of other companies 1981

Box 21, Folder 16-17

Private Placement Memorandum 1982 - 1984

Box 22, Folder 1

Product proposals, undated

Box 22, Folder 2-4

Report and financial statements 1983 - 1988

Box 22, Folder 5

Resolution Amending Articles of Incorporation as to Series B Convertible Preferred Stock, undated

Box 22, Folder 6

Series B Convertible Preferred Stock Purchase Agreement 1984

Box 22, Folder 7

Series B Convertible Preferred Stock Registration Rights Agreement 1984

Box 22, Folder 8

Shareholder Consent Form 1989

Box 22, Folder 9

Unidentified report, undated

 

McKewon and Timmons Investment Bankers

Box 22, Folder 10

Correspondence 1983 - 1987

Box 22, Folder 11

News clippings 1984

Box 22, Folder 12

Private Placement Memorandum 1983

Box 22, Folder 13

Quarterly reports 1984 - 1986

 

Immunetech, Inc.

Box 22, Folder 14

Agreement for Purchase and Sale of Assets between Robert Hamburger, APCo, Inc. and Immunetech, Inc. 1981

Box 22, Folder 15

Agreements between Herbert S. Lightstone and Immunetech, Inc. 1982 - 1984

Box 22, Folder 16

Balance sheet 1984

Box 22, Folder 17

Brochures, undated

Box 22, Folder 18

Business plan 1983

Box 22, Folder 19

Business plan summary 1989 - 1992

Box 22, Folder 20

Certificate of Amendment of Articles of Incorporation 1982

Box 22, Folder 21

Company logo photograph 1981

Box 22, Folder 22

Confidential Disclosure Agreement, undated

Box 22, Folder 23-25

Corporate overview 1982 - 1983

 

Correspondence

Box 23, Folder 1

Accounts payable 1988

Box 23, Folder 2

Administrative office 1986 - 1988

Box 23, Folder 3

Bausch and Lomb, Inc. 1985

Box 23, Folder 4

Blair, James 1985

Box 23, Folder 5

Brucker, Donald 1982 - 1985

Box 23, Folder 6

Down, Lisa and Norman 1983

Box 23, Folder 7

Dura Pharmaceuticals 1990

Box 23, Folder 8

Hahn, Gary S 1981 - 1985

Box 23, Folder 9

Himel, G 1982

Box 23, Folder 10

Kornberg Associates 1983

Box 23, Folder 11

Lightstone, Herbert S 1983 - 1986

Box 23, Folder 12

Lyon and Lyon Law Offices 1983

Box 23, Folder 13

McKewon, Ray 1981 - 1986

Box 23, Folder 14

Merck, E., undated

Box 23, Folder 15

Nelson, Norman 1982

Box 23, Folder 16

O'Connor, Richard 1982

Box 23, Folder 17

Pallai, Peter 1981

Box 23, Folder 18

Phillips and Phillips, Attorneys at Law 1981 - 1982

Box 23, Folder 19

Plummer, James 1985

Box 23, Folder 20

Ramseier, Gordon 1988

Box 23, Folder 21-22

Rangus, Kathryn 1983 - 1987

Box 23, Folder 23

Richieri, Steven P 1989

Box 23, Folder 24

Schmidt, Todd W 1986 - 1989

Box 23, Folder 25

Shareholder materials 1984 - 1991

Box 23, Folder 26

UCSD Office of Contract and Grant Administration 1982

Box 23, Folder 27

Yakatan, Gerald J 1989

Box 23, Folder 28

Development and License Agreement between Bausch and Lomb, Inc. and Immunetech, Inc. 1985

Box 23, Folder 29

Employment agreement, undated

Box 23, Folder 30

Expenses and financing 1981 - 1986

Box 24, Folder 1-2

Financial statements 1981 - 1986

Box 24, Folder 3

Human Complement System Proposal 1982

Box 24, Folder 4

Investigator brochure 1988

Box 24, Folder 5

Loan and Equity Investment Agreement 1986

Box 24, Folder 6

Meetings 1981: Board of Directors (first) meeting - Minutes

Box 24, Folder 7

Meetings 1981: Research meeting - Agenda

Box 24, Folder 8

Meetings 1982: Building planning meeting - Minutes

Box 24, Folder 9

Meetings 1982: Meeting agendas

Box 24, Folder 10-12

Meetings 1983-1985: Board of Directors meetings - Agendas and minutes

Box 24, Folder 13

Meetings 1985: FDA meeting - Agenda and minutes

Box 24, Folder 14

Meetings 1985: Research presentation schedules

Box 24, Folder 15

Meetings 1985: Scientific Advisory Board meetings - Agendas and minutes

Box 24, Folder 16

Meetings 1986: Board of Directors meetings - Agendas and minutes

Box 24, Folder 17

Meetings 1986: Scientific Advisory meetings - Agendas

Box 24, Folder 18

Meetings 1987: Scientific Advisory meeting - Agenda

Box 24, Folder 19

Meetings 1987-1990: Shareholder meetings - Announcements

Box 24, Folder 20

News clippings 1976 - 1990

Box 24, Folder 21

Notes on business and research 1982 - 1986

Box 24, Folder 22

Private Placement Memorandum 1984

Box 25, Folder 1-2

Private Placement Memorandum 1985 - 1986

Box 25, Folder 3

Product Agreement with Merck 1986

Box 25, Folder 4

Promissary Notes 1985

Box 25, Folder 5

Proposal for the Acquisition of ABC Pharmaceuticals by Immunetech Pharmaceuticals 1989

Box 25, Folder 6

Proposal to Endow a Chair in the Pediatric Immunology and Allergy Division, UCSD School of Medicine 1982

Box 25, Folder 7

Report and financial statements 1982 - 1983

Box 25, Folder 8

Restated Articles of Incorporation 1986 - 1989

Box 25, Folder 9

Retainer Agreement with Enterprise Management Company 1981

Box 25, Folder 10

Securities and Exchange Commission Registration Statement 1984

Box 25, Folder 11

Securities Purchase Agreement 1986

Box 25, Folder 12-13

Stockholder documents 1981 - 1991

Box 25, Folder 13

Stockholder documents 1986 - 1991

Box 25, Folder 14

Technology Sharing Agreement between Immunetech, Inc. and Cytotech, Inc. 1982

Box 25, Folder 15

Unanimous Written Consent of Directors 1986

Box 25, Folder 16

Weingart Protein Sequencer Laboratory results 1983

 

Immunetech Research Partners

Box 25, Folder 17

Agreement between Immunetech Research Partners and the Enterprise Management Company 1981

Box 25, Folder 18

Comprehensive Option Agreement between Immunetech Research Partners and Immunetech, Inc. 1981

Box 25, Folder 19

Discussion of Management's Proposal for Immunetech Research Partners "Roll Up" 1983

Box 25, Folder 20

Escrow Instructions 1981

Box 25, Folder 21

Fictitious Business Name Statement 1981

Box 25, Folder 22

License Agreement, draft 1981

Box 25, Folder 23

Partnership Agreements between R. Hamburger, R. O'Connor and G. Hahn to form Immunetech Research Partners 1980 - 1981

Box 26, Folder 1

Private Placement Memorandum June 1981

Box 26, Folder 2

Private Placement Memorandum July 1981

Box 26, Folder 3

Proposed Concept for a New Business 1980 - 1981

Box 26, Folder 4

Quarterly Progress Reports 1982

Box 26, Folder 5

Research and Development Agreement between Immunetech Research Partners and Immunetech, Inc. 1981

Box 26, Folder 6

Retainer Agreement 1981

Box 26, Folder 7

Special Report 1982

Box 26, Folder 8

Technology License Agreement between Immunetech Research Partners and Immunetech, Inc. 1981

 

Syntex Corporation

Box 26, Folder 9

Consulting Agreement between Syntex and Robert Hamburger 1976

Box 26, Folder 10

License Agreement between Syntex and University of California Regents 1976

Box 26, Folder 11

Press release 1976

 

PROFESSIONAL ORGANIZATIONS

 

American Academy of Allergy

Box 26, Folder 12

Correspondence 1976 - 1980

Box 26, Folder 13

In Vitro Tests Committee, research data, meeting agendas and minutes 1976

Box 26, Folder 14

American Academy of Allergy and Immunology - Correspondence, rosters and meeting minutes 1980 - 1990

Box 26, Folder 15

American Academy of Pediatrics - Correspondence 1978 - 1980

Box 26, Folder 16

American Association for Clinical Immunology and Allergy - Correspondence 1978 - 1981

Box 26, Folder 17

American College of Allergists - Correspondence 1980 - 1986

Box 26, Folder 18

American College of Allergy and Immunology - Correspondence and committee list 1988 - 1990

Box 26, Folder 19

American Pediatric Society - Correspondence 1972 - 1982

Box 26, Folder 20

California Committee on Therapeutic Abortion - Correspondence 1966 - 1969

Box 26, Folder 21

California Medical Association - Correspondence 1982 - 1983

Box 26, Folder 22

California Society of Allergy and Clinical Immunology - Correspondence 1972 - 1990

Box 26, Folder 23

Children's Hospital Education Committee - Correspondence 1968

Box 26, Folder 24

Clinica de Salubridad de Campesinos - Correspondence 1974 - 1981

Box 26, Folder 25

First Mexican-American Congress of Clinical Immunology and Allergy - Correspondence and meeting materials 1981

Box 27, Folder 1

Interasma - Correspondence 1978 - 1988

Box 27, Folder 2

Los Angeles Society of Allergy and Clinical Immunology - Correspondence 1976

Box 27, Folder 3

North County Health Services - Correspondence 1980 - 1982

Box 27, Folder 4

Nuffield Foundation 4th Nuffield Conference on Rheumatism - Correspondence, meeting and travel materials 1969

Box 27, Folder 5

San Diego Allergy Sociey 1st Annual Seminar - Program of events 1976

Box 27, Folder 6

San Diego County Medical Society - Correspondence 1979 - 1980

Box 27, Folder 7

San Diego County Mental Health Association - Correspondence 1958 - 1964

Box 27, Folder 8

San Diego Pulmonary Society Conference - Program of events 1975

Box 27, Folder 9

Society for Pediatric Research - Correspondence 1964 - 1969

Box 27, Folder 10

UCSD Ninth Annual Course, Immunology and the Clinical Practice of Allergy - Program of events 1985

Box 27, Folder 11

Western Society for Pediatric Research - Correspondence 1969 - 1983

 

UCSD GENERAL CAMPUS

Box 28, Folder 1-8

Academic Senate. Special Committee on Medical Education 1960-1965

Box 29, Folder 1

Academic Senate. Special Committee on Medical Education - Expanded - Correspondence 1966-1967

Box 29, Folder 2

Atkinson, Richard 1980-1990

Box 29, Folder 3-5

Budget Committee 1964-1966

Box 29, Folder 6-7

Chancellor's Advisory Committee on Equal Opportunity in Employment at UCSD 1964-1968

Box 29, Folder 8

Experimental High School Program Committee 1969

Box 30, Folder 1-2

Planning for UCSD overall - UC overall 1966-1968

Box 30, Folder 3

Project 73 Committee 1965-1966

 

Quartet Series (UCSD Chamber Music Series)

Box 40, Folder 1-8

1975 - 1988

Box 41, Folder 1

1989 - 1991

Box 30, Folder 4

Second College - Planning committee 1964-1966

Box 30, Folder 5

Stern, Herb. Inaugural talk

Box 30, Folder 6

Third College - Operation Opportunity - Upward Bound Project, Subcommittee on Special Scholarships 1968-1969

Box 30, Folder 7

Third College Planning Committee 1969

 

UCSD SCHOOL OF MEDICINE

Box 30, Folder 8

25th UCSD Anniversary Oral History Project - School of Medicine - Interview with Robert Hamburger - Final draft with edits 1984

Box 30, Folder 9

Ad Hoc Committee to consider methods for utlizing San Diego County Pound dogs and cats 1966

Box 30, Folder 10

Advisor's Handbook 1968-1971

Box 31, Folder 1

Animal Care Panel - San Diego Branch. American Association for Laboratory Animal Science 1965-1967

 

Animal Facilities

Box 31, Folder 2-3

Correspondence 1965-1983

Box 31, Folder 4

General 1966-1971

Box 31, Folder 5

Animal Resources 1966-1980

Box 31, Folder 6

Basic Science Building 1966

Box 31, Folder 7

Basic Science Building Committee 1967-1968

Box 31, Folder 8

Bellagio Study and Conference Center - Correspondence 1986

Box 31, Folder 9

Beneficial Occupancy Committee 1968

Box 31, Folder 10

Building Advisory Committee for the South Campus 1967

Box 30, Folder 11

Building Advisory Subcommittee for Clinical Science Building 1, 2, La Jolla Campus Hospital and County - University Hospital 1966-1967

Box 32, Folder 1-2

Camp Elliott Advisory Committee 1966-1970

Box 32, Folder 3

Camp Elliott Animal Farm 1966-1968

Box 32, Folder 4

Clinical Science Building 1967-1969

Box 32, Folder 5-7

Clinical Science Building Advisory Committee 1965-1969

Box 32, Folder 8

Clinical Science Building Project Site Visit, January 1968

Box 32, Folder 9

Clinical Science Building Subcommittee 1966-1967

Box 33, Folder 1

Commencement exercises - Scripts, June, 5 1994

Box 33, Folder 2-3

Committee on Educational Policy 1966-1970

Box 33, Folder 4

Committee on Electives 1967-1968

Box 33, Folder 5

Committee on Evaluation and Grading 1968-1971

Box 33, Folder 6

Committtee on Investigations Involving Human Beings 1966-1968

Box 33, Folder 7

Committee to Develop a Master Plan for the Biomedical Use of Camp Elliott 1968-1969

Box 33, Folder 8

Community Medicine 1968-1972

Box 33, Folder 9-10

Core Curriculum Committee 1967-1969

Box 33, Folder 11

Correspondence - Includes letter from Richard Nixon 1968-1994

Box 33, Folder 12

Council of Chairman (Formerly called General Executive Council) 1966-1968

Box 34, Folder 1

Council of Chairman (Formerly called General Executive Council) 1968-1972

Box 34, Folder 2

Dean's Office 1967-1968

Box 34, Folder 3

Developmental Program Grants 1968

Box 34, Folder 4

Early Admissions Subcommittee of the Admissions Committee 1970

Box 34, Folder 5

Elliott Field Station Advisory Committee - Includes annual report 1971-1972

Box 34, Folder 6

Enrollment Projections 1965-1967

 

Expert Groups on Elective Concentration Areas Committee 1968-1969

Box 34, Folder 8

First Mexican-American Congress of Clinical Immunology and Allergy, November 1981

 

First Year Curriculum Committee

Box 34, Folder 9-11

Includes pamphlets on other Schools of Medicine 1964-1966

Box 34, Folder 12

First Year Curriculum Committee - Correspondence 1965-1966

Box 35, Folder 1

First Year Curriculum Committee - Correspondence 1966-1967

Box 35, Folder 2-3

First Year Curriculum Committee - Minutes 1966-1967

Box 35, Folder 4

Full Time Employee - UC and School of Medicine 1966-1967

Box 35, Folder 5

General Space Allocations (Lab, Offices, etc.) 1966-1968

Box 35, Folder 6

Graduate Program Accreditation 1982-1983

Box 35, Folder 7

Grants, Additions, and Inserts 1968

Box 35, Folder 8

Improvements at University Hospital - Project Planning Guide. 1970-1971 January 31, 1969

Box 35, Folder 9

Interview of Robert Donald Tschirgi - Transcript 1981

Box 35, Folder 10

Interview of Dean G. Burrow by Robert Hamburger - Transcript April 17, 1989

Box 36, Folder 1

Janis, Irving L. 1973

Box 36, Folder 2

John M. and Sally B. Thornton Hospital - Groundbreaking Ceremony - Program March 7, 1990

Box 36, Folder 3

Joint Research with David Marsh 1974-1975

Box 36, Folder 4

Major Capital Improvements 1967

Box 36, Folder 5

Mental Retardation Research and Training Committee 1968

Box 36, Folder 6

Miscellaneous 1964-1976

Box 36, Folder 7

Neuroimmune Physiology Program - Gift Fund 1988

Box 36, Folder 8

Neurosciences Department 1968-1969

Box 36, Folder 9

Obstetrics and Gynecology Department 1968

Box 36, Folder 10

Office Space - Pediatric Office Space, Basic Science Building, La Jolla Campus 1968-1969

Box 36, Folder 11

Pathology Department 1968-1977

Box 36, Folder 12-13

Peace Corps Training Program 1966-1967

 

Pediatric Immunology and Allergy Division (PIAD)

Box 36, Folder 14-15

1977-1987

Box 37, Folder 1

Miscellaneous 1969-1988

Box 37, Folder 4-5

Residency Training Program 1974-1988

Box 37, Folder 6

Pediatrics Department 1977

Box 37, Folder 7

School of Medicine Planning 1964-1969

Box 38, Folder 1

Planning Guides for School of Medicine 1969-1983

Box 38, Folder 2

Proposal for New Departments in the School of Medicine

Box 38, Folder 3

Quantitation of Some of the Variables in Allergy - Grant Materials 1978

Box 38, Folder 4

Recruitment and Admissions Committee 1966-1970

Conditions Governing Access

Restricted
Box 38, Folder 5

Recruitment of Dr. Bonner, Dr. Zimm and Dr. Salk - Newsclippings

Box 38, Folder 6

Regional Medical Program Advisory Committee 1966-1967

Box 38, Folder 7

Review and Updating of the Immunology and Clinical Practice of Allergy, San Diego - Brochures 1977-1979

Box 38, Folder 8

Research Institutes at UCSD 1966-1967

Box 38, Folder 9

Residency Training and Pediatric Research Projects: A Study 1965

Box 38, Folder 10

Salk Surge 1968

Box 38, Folder 11

Salk Temporary Buildings 1966-1967

Box 38, Folder 12

San Diego County Public Health Planning 1963

Box 38, Folder 13

Scale "C" Debate 1966-1968

Box 38, Folder 14

Scripps Clinic and Research Foundation 1967

Box 38, Folder 15

Stokes, Joseph III - Speech at Groundbreaking Ceremony for Basic Science Building 1966

Box 38, Folder 16

Strict Full Time Salary. Part I 1965-1968

Box 39, Folder 1

Strict Full Time Salary. Part II 1965-1968

Box 39, Folder 2

Student Affairs - School of Medicine 1966-1968

Box 39, Folder 3

Symposium honoring S. J. Singer - Itinerary August 12, 1995

Box 39, Folder 4

University Hospital - Minority Affairs 1969

Box 39, Folder 5

William L. Nyhan Honorary Dinner - Photographs Robert Hamburger Master of Ceremonies November, 1986

 

ORIGINS OF THE SCHOOL OF MEDICINE AT UCSD

 

Developmental Analysis

Box 39, Folder 6

Correspondence 1971-1994

Box 39, Folder 7

Typescript drafts with annotations 1986-1991

 

Symposium

Box 39, Folder 8

Typescript draft of transcript 1984-1986

Box 39, Folder 9

Correspondence, notes, and photograph 1984-1986