Morris E. Friedkin Papers

Special Collections & Archives
Special Collections & Archives, UC San Diego
Copyright 2005
9500 Gilman Drive
La Jolla 92093-0175
spcoll@ucsd.edu


Descriptive Summary

Languages: English
Contributing Institution: Special Collections & Archives, UC San Diego
9500 Gilman Drive
La Jolla 92093-0175
Title: Morris E. Friedkin Papers
Identifier/Call Number: MSS 0524
Physical Description: 12.3 Linear feet (26 archives boxes and 16 oversize folders)
Date (inclusive): 1919 - 1992
Abstract: Papers of Morris Friedkin, American biochemist, professor and university administrator. His research interests included folic acid metabolism, cancer chemotherapy, enzymology, DNA synthesis, biochemical dynamics of the cell cycle, pharmacology, and positron emission tomography. Materials include laboratory notebooks, loose notes, data, chemical and research product subject files; reprints and typescripts of published and unpublished writings by Friedkin; documents related to grants and fellowships; annotated writings by others; and correspondence. Also included are course materials and notes from Friedkin's time as student at Iowa State College and at University of Chicago; and teaching materials and administrative materials from his time as a faculty member and/or administrator at Washington University, Tufts University, and the University of California, San Diego.

OFF-SITE STORAGE

COLLECTION STORED OFF-SITE: ALLOW ONE WEEK FOR RETRIEVAL OF MATERIALS

Scope and Content of Collection

The Morris E. Friedkin Papers document the professional career of the American biochemist whose research interests throughout his lifetime included folic acid metabolism, cancer chemotherapy, enzymology, DNA synthesis, the biochemical dynamics of the cell cycle and cell growth, pharmacology, the use of radioactively-labeled molecules in biochemical research, and positron emission tomography. Materials reflecting Friedkin's scientific activities include an extensive but incomplete set of laboratory notebooks, documents related to specific research projects, information Friedkin collected on specific chemicals and laboratory products, loose data, miscellaneous research notes, and descriptions of laboratory techniques. Other materials include documents related to Friedkin's grants and fellowships, correspondence, reprints and typescripts of Friedkin's writings, and manuscripts or typescripts of lectures about his research. Also included are notes and materials from courses Friedkin took as an undergraduate at Iowa State College and as a graduate student at the University of Chicago. Finally, the papers contain materials related to Friedkin's teaching and administrative duties at the Washington University School of Medicine, Tufts University School of Medicine, and the University of California, San Diego, School of Medicine. The papers are arranged in ten series: 1) BIOGRAPHICAL MATERIALS, 2) CORRESPONDENCE, 3) EDUCATION MATERIALS, 4) GRANTS AND FELLOWSHIPS, 5) RESEARCH MATERIALS, 6) WRITINGS BY FRIEDKIN, 7) TEACHING AND ADMINISTRATIVE MATERIALS, 8) WRITINGS BY OTHERS, 9) MISCELLANEOUS MATERIALS, and 10) ORIGINALS OF PRESERVATION PHOTOCOPIES.
SERIES 1: BIOGRAPHICAL MATERIALS
The BIOGRAPHICAL MATERIALS series, arranged alphabetically, contains materials documenting significant events in Friedkin's life such as his birth certificate, his doctoral diploma, materials regarding his sabbatical leaves, and two personal logs with regular entries.
SERIES 2: CORRESPONDENCE
The CORRESPONDENCE series is arranged in three subseries: A) Chronological Files, B) A to Z Files, and C) Letters of Recommendation.
A) The Chronological Files subseries is arranged chronologically. The order and content of these files remain unchanged from their original state except that letters of recommendation written for or by Friedkin were seperated and placed into their own folder in the Letters of Recommendation subseries.
B) The A to Z Files subseries, arranged alphabetically by correspondent, contains letters written to or from Friedkin from 1948 to 1987. Included is correspondence with the renowned biochemist and Friedkin's graduate advisor, Albert Lehninger.
C) The Letters of Recommendation subseries contains letters of recommendation, arranged chronologically, written by Friedkin for students, colleagues, and employees. Also included are letters of recommendation written for Friedkin.
SERIES 3: EDUCATION MATERIALS
The EDUCATION MATERIALS series is arranged in three subseries: A) Iowa State College, B) University of Chicago, and C) Stanford University.
A) The Iowa State College subseries, arranged alphabetically, contains materials related to courses Friedkin attended at his undergraduate institution, Iowa State College, from 1939 to 1941. Materials include course notes, laboratory notes, written reports, and course handouts from courses in biochemistry, chemistry, colloid chemistry, and sanitary bacteriology.
B) The University of Chicago subseries, arranged alphabetically, contains materials related to courses Friedkin attended at his graduate institution, the University of Chicago, from 1942 to 1948. Materials include course notes and notebooks, laboratory notes and notebooks, course handout, written assignments, and copies of examinations from courses in biochemistry and genetics.
C) The Stanford University subseries, arranged alphabetically, contains materials from a course in microbiology Friedkin took at Stanford University in 1956. Materials include course notes and notebooks, a poster of microrganisms, and course handouts.
SERIES 4: GRANTS AND FELLOWSHIPS
The GRANTS AND FELLOWSHIPS series is arranged in two subseries: A) New Antagonists of Amethopterin-Resistant Leukemia and B) Miscellaneous.
A) The New Antagonists of Amethopterin-Resistant Leukemia subseries, arranged chronologically, contains documents related to Friedkin's longest continuous grant from the Department of Health, Education and Public Welfare at the National Institutes of Health for the funding of a project entitled "New Antagonists of Amethopterin-Resistant Leukemia" from 1968 to 1985. Included are grant applications, correspondence, notices of research projects, progress reports, project evaluations, and documents related to Friedkin's subcontracting of SRI International.
B) The Miscellaneous subseries, arranged chronologically, contains materials related to Friedkin's other grants and fellowships. Materials include applications, correspondence, and miscellaneous records from Friedkin's United States Public Health Service postdoctoral fellowship at the University of Copenhagen in 1948 to his application to the University of California, San Diego, for funding of a project entitled "Synthesis of Difluoromethylornithine" in 1988.
SERIES 5: RESEARCH MATERIALS
The RESEARCH MATERIALS series is arranged in four subseries: A) Laboratory Notebooks and Notes, B) Projects, C) Chemical and Product Information, and D) Data and Laboratory Techniques.
A) The Laboratory Notebooks and Notes subseries, arranged alphabetically, contains laboratory notebooks and loose research notes from the 1940s to the 1980s. Included are loose notes from short periods during which Friedkin worked at the Brookhaven National Laboratory in the 1950s, 1960s, and 1980s. Also included are laboratory notebooks which Friedkin numbered from the period of his dissertation research at the University of Chicago in the late 1940s to the period of his research at the University of California, San Diego, in the late 1970s. Although the labels on the notebooks are numerically discontinuous, the content of the notebooks are continuous chronologically from 1946 to 1973. Also included are a few unnumbered laboratory notebooks and a folder of miscellaneous research notes.
B) The Projects subseries, arranged alphabetically, contains materials related to specific research projects from 1968 to 1988. Materials include loose research notes, data, graphs, writings by others, and photographs or other illustrations for projects on phosophoserine, cell proliferation, colchine, DNA, folic acid, microtubules, a possible leukemia inhibitor, and thymidylate synthetase.
C) The Chemical and Product Information subseries, arranged alphabetically, contains materials collected by Friedkin concerning chemicals or laboratory products of interest and possibly used in his research. Included are writings by others annotated by Friedkin, notes, and product pamphlets.
D) The Data and Laboratory Techniques subseries, arranged alphabetically, contains materials which are not related to any of the materials in the other RESEARCH MATERIALS subseries. Included are data collected by Friedkin's students and research assistants, data from specific experiments, annotated writings by others on laboratory techniques, and typescripts of laboratory protocols.
SERIES 6: WRITINGS BY FRIEDKIN
The WRITINGS BY FRIEDKIN series is arranged in three subseries: A) Numbered Publications, B) Lectures, and C) Unnumbered Publications and Unpublished Writings.
A) The Numbered Publications subseries, arranged chronologically, contains reprints, typescript drafts, and drafts of figures for writings published by Friedkin in professional and scholarly journals from 1945 to 1985. Included is a publication list from the collection that lists Friedkin's publications chronologically and numbers them from 1 to 122. The set of numbered publications is incomplete.
B) The Lectures subseries, arranged chronologically, contains materials from lectures Friedkin gave on various biochemical topics at professional conferences or at other universities. Included are miscellaneous lecture announcements and manuscripts or typescripts of his lectures.
C) The Unnumbered Publications and Unpublished Writings subseries, arranged alphabetically, contains reprints or photocopies of published articles that are not on the numbered publication list, manuscripts or typescripts of papers reviewed but not accepted for publication, a typescript copy of Friedkin's dissertation, and other miscellaneous writings.
SERIES 7: TEACHING AND ADMINISTRATIVE MATERIALS
The TEACHING AND ADMINISTRATIVE MATERIALS series is arranged in three subseries: A) Washington University School of Medicine, B) Tufts University School of Medicine, and C) UCSD School of Medicine.
A) The Washington University School of Medicine subseries, arranged chronologically, contains mostly course handouts and manuscripts or tyepscripts of lectures for biochemistry or statistics courses taught by Friedkin. Included are photographs of some of the research facilities at Washington University. Both the teaching and administrative materials are arranged chronologically, but they are not interfiled. The teaching materials, arranged chronologically, appear first and any administrative materials follow, also arranged chronologically.
B) The Tufts University School of Medicine subseries, arranged chronologically, contains both teaching and administrative materials. Included are Tufts University School of Medicine yearbooks, a bound collection of articles produced by the faculty of the Department of Biochemistry during Friedkin's time as chair of the department, newspaper clippings, miscellaneous administrative materials, and two folders of miscellaneous laboratory floorplans. Also included are course handouts and typescripts of lectures for courses Freidkin taught at Tufts. Teaching materials, arranged chronologically, appear first in the subseries while any administrative materials, arranged chronologically, follow the teaching materials. The two groups of materials are not interfiled within the subseries.
C) The UCSD School of Medicine subseries is arranged in the same manner as the previous two subseries with the teaching materials, arranged chronologically, followed by the administrative materials, also arranged chronologically. Included are course handouts and lecture manuscripts for biochemistry courses Friedkin taught in the 1970s. Also included are materials related to Friedkin's work as provost of Revelle College (1974-1976), and a restricted file of documents related to Friedkin's role as an investigator of a complaint of scientific misconduct.
SERIES 8: WRITINGS BY OTHERS
The WRITINGS BY OTHERS series, arranged alphabetically, contains reprints or typescripts of articles on biochemistry or related topics, many with notations, collected by Friedkin.
SERIES 9: MISCELLANEOUS MATERIALS
The MISCELLANEOUS MATERIALS series, arranged alphabetically, contains materials unrelated to any other series in the collection. Included are materials documenting Friedkin's attendance at various professional conferences, miscellaneous slides presumably related to Friedkin's lectures, letters Friedkin wrote to politicians concerning the war in Vietnam, newspaper clippings, and documents related to Friedkin's review of the graduate pharmacology program at the University of California, San Francisco.
SERIES 10: ORIGINALS OF PRESERVATION PHOTOCOPIES
The ORIGINALS OF PRESERVATION PHOTOCOPIES series contains the originals of brittle or high acid content documents that have been photocopied.

Biography

Morris E. Friedkin was born on December 30, 1918, in Kansas City, Missouri. Upon finishing high school in 1936, he entered Kansas City Junior College and received an A.A. in chemistry in 1938. Friedkin continued his education at Iowa State College receiving a B.S. in chemistry in 1940 and an M.S. in analytical chemistry in 1941. After completing his master's degree, he enrolled in the doctorate program in biochemistry at the University of Chicago where he was one of the first graduate students of the renowned biochemist, Albert Lehninger. In 1948, Morris Friedkin completed his Ph.D. with the submission of his dissertation entitled "Studies on Aerobic Phosophorylation." After receiving his doctorate, he continued his studies for one year as a postdoctoral fellow of the National Institutes of Health at the University of Copenhagen.
Friedkin returned to the United States in 1949 and accepted a faculty position in the Department of Pharmacology at the Washington University School of Medicine. In 1957, he joined the faculty of the Department of Pharmacology at the Tufts University School of Medicine where he also served as chair of the department in addition to his teaching and research responsibilities. In 1969, looking to devote more time to research and less to administrative duties, he moved to the Department of Biology at the University of California, San Diego, School of Medicine. For the remainder of his professional career at UCSD except for a short appointment as provost of Revelle College (1974-1976), Friedkin focused exclusively on research and teaching.
Throughout his career, Friedkin worked in many different areas of biochemical research usually with the aim of developing chemotherapies for medicinal application. While attending the University of Chicago, he worked as chemist on the "Penicillin Project" at the Northern Regional Research Laboratory. In 1966, the United States Army contracted with Friedkin to explore new areas in the development of drugs for malaria-resistance. Also in the 1960s, he began his career-long study of cancer chemotherapy with particular interest in the treatment of leukemia. In the course of over forty years of scientific research, Friedkin's contributions advanced scientific understanding in many areas of biochemistry including folic acid metabolism, the biochemical basis of the cell cycle and cell growth, the use of radioactively labeled molecules in biochemical research, molecular pharmacology, DNA synthesis, the structure and function of microtubules, and positron emission tomography. He published regularly in scholarly journals throughout his career and was honored with membership to the National Academy of Sciences in 1978.
Morris Friedkin retired from his position in the Department of Biology at the University of California, San Diego School of Medicine in 1989. He died on September 19, 2002.

Preferred Citation

Morris E. Friedkin Papers, MSS 524. Special Collections & Archives, UC San Diego.

Acquisition Information

Not Available

Access

In accordance with state and federal law, materials in Box 3, Folder 18 and Box 24, Folder 12 are restricted until 2067.

Subjects and Indexing Terms

Molecular biologists -- Archives
Cancer -- Chemotherapy -- Research

 

BIOGRAPHICAL MATERIALS

Box 1, Folder 1

Curriculum vitae undated

Box 1, Folder 2

Diploma - University of Chicago 1948

Box 1, Folder 3

Employment materials - United States Department of Agriculture and University of Chicago 1941 - 1946

Box 1, Folder 4

Kaiser-Permenente Excellence in Teaching Award 1981 - 1982

Box 1, Folder 5

Letters of Certification from the Iowa State College Registrar 1940 - 1946

Box 1, Folder 6

Newspaper clippings mentioning Friedkin 1965 - 1975

 

Personal logs

Box 1, Folder 7

Notebook containing autobiographical, travel, and lecture notes from the period when Friedkin was at the University of Copenhagen 1948 - 1949

Box 1, Folder 8

Notebook containing some research related notes but primarily autobiographical journal entries 1957 - 1989

Box 1, Folder 9

Photograph - Friedkin in front of Geisel Library

Box 1, Folder 10

Sabbatic leaves - Program statements, sabbatical leave reports and correspondence 1972 - 1988

Box 1, Folder 11

Transcript of birth record 1919

 

CORRESPONDENCE

 

Chronological Files

Box 1, Folder 12-16

1951 - 1955

Box 2, Folder 1-2

1956 - 1957

Box 2, Folder 3-8

1982 - 1987

 

A to Z Files

Box 2, Folder 9

A to L - Miscellaneous 1948 - 1987

Box 2, Folder 10

M to Z - Miscellaneous 1948 - 1985

Box 2, Folder 11

Baer, Ed 1979

Box 2, Folder 12

Bertino, Joseph R. 1963 - 1989

Box 2, Folder 13

Bishop, George - Includes article manuscripts and glass slides 1958 - 1961

Box 2, Folder 14

Brandt, Sven 1948

Box 2, Folder 15

Brunsletter, Byron C. 1948

Box 2, Folder 16

Gates, Betsy Jane 1978 - 1979

Box 2, Folder 17

Grossowicz, Nathan 1980 - 1982

Box 2, Folder 18

Hoffman-LaRoche Inc. 1979 - 1981

General note

Correspondents: Alan F. Cook, Michael Drzyzga and W. E. Scott.
Box 2, Folder 19

Huennekens, Frank M. 1965 - 1967

Box 2, Folder 20

Kalckar, Herman M. 1948 - 1978

Box 2, Folder 21

Koppelman, Ray 1963 - 1964

General note

Correspondence with Abel Hoffman is stapled to some of the Koppelman letters.
Box 2, Folder 22

Kornberg, Arthur 1959 - 1977

Box 2, Folder 23

Lederle Laboratories 1961 - 1963

General note

Correspondents: Robert B. Angier and E. L. Robert Stokstad.
Box 2, Folder 24

Lehninger, Albert L. 1949 - 1985

Box 2, Folder 25

Lindsley, Dan 1978 - 1979

Box 2, Folder 26

Livingston, David 1969 - 1982

Box 3, Folder 1

Lowry, Oliver H. 1949 - 1989

Box 3, Folder 2

Maloney, William F. 1966 - 1968

Box 3, Folder 3

Mathews, Christopher K. 1963 - 1965

Box 3, Folder 4

McQuade, Henry 1958 - 1975

Box 3, Folder 5

National Institutes of Health 1952 - 1984

General note

Correspondents: E. P. Cronkite, Irvin Fuhr, Abraham Goldin, Dwijendra K. Misra, Moreshwar Nadkarni, Mary V. Niemic, Kenneth Paull, Frederick Stohlmann, and C. Gordon Zubrod.
Box 3, Folder 6

Plante, Larry 1988

Box 3, Folder 7

Plowman, Jacqueline 1984

Box 3, Folder 8

Rizack, Martin A. 1959 - 1960

Box 3, Folder 9

Roche Products Limited 1983

General note

Correspondents: Frank R. Atherton, C. H. Hassall and N. R. Rogers.
Box 3, Folder 10

Rozengurt, Henry (Enrique) 1979 - 1982

Box 3, Folder 11

Schwarz Laboratories Inc. 1959

Box 3, Folder 12

Silber, Robert 1962 - 1963

Box 3, Folder 13

Singer, S. Jonathan 1964

Box 3, Folder 14

Sprinson, David B. 1959

Box 3, Folder 15

Stone, Frederick L. 1948 - 1949

Box 3, Folder 16

Strominger, Jack 1961 - 1962

Box 3, Folder 17

Unidentified correspondents

 

Letters of Recommendation

Box 3, Folder 18

1953 - 1987

Conditions Governing Access note

Restrictions Apply
 

COLLEGE MATERIALS

 

Iowa State College

Box 3, Folder 19

Biochemistry 301 1941

Box 3, Folder 20

Biochemistry, untitled - Course notes 1941

Box 3, Folder 21

Chemistry 512 - Course notes and lab materials 1941

Box 3, Folder 22

Chemistry 519, Microquant - Course notes 1941

Box 3, Folder 23

Chemistry 531 - Course notes ca. 1941

Box 3, Folder 24

Colloid Chemistry - Course handouts and notes 1939

Box 3, Folder 25

Sanitary Bacteriology - Course notes, typescript drafts of assignments and handouts 1940

 

University of Chicago

Box 4, Folder 1

Biochemistry 201 - Course handouts and examinations 1945 - 1946

Box 4, Folder 2-3

Biochemistry 202 - Course handouts, lab materials, notebook, and examinations 1945 - 1948

Box 4, Folder 4-6

Biochemistry 305 - Course handouts, notebooks, notes and examinations 1942 - 1948

Box 4, Folder 7-8

Biochemistry 306 - Course notes, handouts, notebook, and examinations 1946

 

Genetics 211

Box 4, Folder 9

Course notes, handouts and written assignments 1945

Box 4, Folder 10

The Unity of Genetics and Biochemistry in Phenylpyruvic Oligophrenia - Typescript 1945

Box 4, Folder 11

Unidentified course notes 1950

 

Stanford University

 

Introduction to Microbiology

Box 4, Folder 12

Course description and notes 1956

Box 4, Folder 13, Oversize FB-282-09

Poster 1956

Box 5, Folder 1-2

Spiral notebooks 1956

 

GRANTS AND FELLOWSHIPS

 

New Antagonists of Amethopterin-Resistant Leukemia

Box 5, Folder 3

Progress Reports 1963 - 1987

Box 5, Folder 4

Correspondence 1968 - 1987

Box 5, Folder 5

Grant Applications 1968 - 1984

Box 5, Folder 6

Grant Applications Appendices 1968 - 1984

Box 5, Folder 7

Notices of Grant Awarded 1969 - 1985

Box 6, Folder 1

Applications for Continuation Grant 1970 - 1985

Box 6, Folder 2

Notices of Research Project 1976 - 1982

Box 6, Folder 3

Project Evaluations 1977 - 1985

Box 6, Folder 4

SRI International - Project proposal and correspondence 1980 - 1984

 

Miscellaneous

Box 6, Folder 5

United States Public Health Service Fellowship - Application, correspondence and progress report 1948

Box 6, Folder 6

Graduate Training Grant - Applications, progress reports, correspondence, and Tufts University pharmacology graduate program guide 1960 - 1968

Box 6, Folder 7

Design of New Antifolates for Use in Drug-Resistant Malaria - Application, progress reports, photographs, and related article reprints 1961 - 1967

 

Biochemistry of the Transition from Quiescence to Replicative Growth in the Cell Cycle..

Box 6, Folder 8

Guggenheim Fellowship - Application, notes, pamphlets, and correspondence 1972 - 1978

Box 6, Folder 9

Eleanor-Roosevelt International Cancer Fellowship - Application, notes, correspondence, and progress reports 1977 - 1979

Box 6, Folder 10

Macy Faculty Scholar Award - Application, notes and correspondence 1978

Box 6, Folder 11

Role of Cytoplasmic Microtubules in the Regulation of the Activity of Peptide Growth Factors - Applications to the National Science Foundation and American Cancer Society 1981 - 1983

Box 6, Folder 12

Effects of Amino Acid Phosphonate (APBA) on the Growth of Mouse Leukemic Cells - Application and correspondence 1984

Box 6, Folder 13

Effects of 2-Amino-4-Phosphono-Butyric Acid on the Growth of L1210 Murine Leukemia Cells from Exponential... - Applications, applications for continuation grant and correspondence 1985

Box 6, Folder 14

Inhibitory Effects of Phosphono Amino Acids on the G0/G1 Period of Leukemia Cells - Application and correspondence 1985 - 1988

Box 6, Folder 15

Inhibition of Leukemia Cells by Phosphono Amino Acids - Applications and correspondence 1985 - 1988

Box 6, Folder 16

Isolation and Identification of CERDLIN (Cation Exchange Resin Derived Leukemia Inhibitor) - Applications 1986

Box 6, Folder 17

Synthesis of Difluoromethylornithine - Application and notes 1988

 

RESEARCH MATERIALS

 

Laboratory Notebooks and Notes

Box 7, Folder 1

Research notes - Miscellaneous 1959 - 1988

 

Brookhaven National Laboratory

Box 7, Folder 2

1957

Box 7, Folder 3

1960 - 1961

Box 7, Folder 4

1962. Sodium Borohydride Tritium Experiments - Notebook, graphs, data tables, and photocopies of writings by others

Box 7, Folder 5

1962 - 1972. Carbon Eleven

Box 7, Folder 6

1986 - 1988

Box 7, Folder 7

Computer notes 1961

Box 7, Folder 8

Experiments 1 to 186 1978 - 1979

Box 8, Folder 1

Experiments 373 to 536 1980 - 1981

Box 8, Folder 2

Experiments 537 to 834 1981 - 1985

Box 8, Folder 3

Experiments 835 to 1159 1985 - 1987

Box 9, Folder 1

Metabolic Scenarios I 1983

Box 9, Folder 2

Methods - Tissue Culture Techniques 1980 - 1981

Box 9, Folder 3

Northern Regional Research Laboratory - Research notes ca. 1941 - 1945

Box 9, Folder 4-5

Notebooks 1986 - 1988

 

University of Chicago

Box 9, Folder 6

Notebooks 1 - 2 1946 - 1947

Box 10, Folder 1-2

Notebooks 3 - 6 1947

Box 10, Folder 3-4

University of Chicago and University of Copenhagen. Notebooks 7 - 10 1948 - 1949

Box 10, Folder 5-6

University of Copenhagen. Notebooks 11 - 12 1949

 

Washington University

Box 11, Folder 1-2

Notebooks 13 - 14 1949 - 1951

Box 11, Folder 3-4

Notebooks 18 - 19 1950 - 1952

Box 12, Folder 1-2

Notebooks 23 - 24 1952 - 1953

Box 12, Folder 3

Notebook 27 1953 - 1954

Box 12, Folder 4

Notebook 33 1954 - 1955

Box 13, Folder 1-4

Notebooks 34 - 37 1955 - 1957

Box 14, Folder 1

Notebook 42 1957

 

Tufts University

Box 14, Folder 2-3

Notebooks 43 & 45 1957 - 1958

Box 14, Folder 4

Notebook 48 1958 - 1959

Box 15, Folder 1

Notebook 57 1959 - 1961

Box 15, Folder 2

Notebook 64 1961 - 1964

Box 15, Folder 3

Notebook 74 1963 - 1965

Box 15, Folder 4

Tufts University and University of California, San Diego. Notebook 84 1965 - 1970

Box 16, Folder 1-2

University of California, San Diego. Notebooks 92 & 95 1970 - 1978

 

Projects

 

Cation Exchange Resin Derived Leukemia Inhibitor (CERDLIN)

Box 16, Folder 3

Data and graphs 1987 - 1988

Box 16, Folder 4

Elemental analysis ca. 1988

Box 16, Folder 5, Oversize FB-360-01

Infrared spectra - Oversize ca. 1987

Box 16, Folder 6, Oversize FB-360-02

Oversize 1987 - 1988

Box 16, Folder 7-8, Oversize FB-360-03

Cell Proliferation Project (L-glutamate, Sodium Butyrate, and Quisqualic Acid) - Data, notes and writings by others 1982 - 1986

Box 17, Folder 1

Colchine Effects on [3H] Uridine and [3H] Thymidine - Data tables and graphs 1981

Box 17, Folder 2

Colchine, unidentified data - Data tables, graphs and writings by others 1968

 

DNA Profiles

Box 17, Folder 3

Aminoethyl Phosphonate (AEP) Log Cells also Quisqualic Acid and 2-Amino-4-Phosophono-Butyric... 1985

Box 17, Folder 4

BUdR Staining and Effect of Taurine 1985

Box 17, Folder 5

Cytofluorometry (Judy Nordberg) 1985

Box 17, Folder 6

Effects of Aminoethyl Phosphonate (AEP), Quisqualic Acid (QQ), and HC (Elizabeth Crawford) 1985

Box 17, Folder 7

Experiment 908 - Effect of Quisqualic Acid on Cell Cycle of L1210 1986

Box 17, Folder 8

PE, PC and Ethanolamine (Elizabeth Crawford) 1985

Box 17, Folder 9

Quisqualic Acid Experiment (Donna Ruthenmeyer) ca. 1985

Box 17, Folder 10

Sed 3 Experiment 1985

Box 17, Folder 11

Folic Acid - Correspondence, data, graphs, notes, and protocols 1961 - 1969

Box 17, Folder 12

Microtubule Theory of Memory - Notes and writings by others 1974 - 1984

 

Phosphoserine Project

Box 17, Folder 13

Correspondence - William Colwell, Jac L. Crase, Joe DeGraw, James D. Haug, Alton Meister, Charles H. Stanmer, and Yoshi Tsujita 1982 - 1984

Box 17, Folder 14

Illustrations undated

Box 17, Folder 15

Miscellaneous - Includes flyers for lectures, technical information of lab equipment and products and other materials ca. 1978 - 1984

Box 17, Folder 16

Notes 1978 - 1984

Box 17, Folder 17

Photographs Ca. 1978 - 1984

Box 17, Folder 18

Starch Gel Electophoresis undated

Box 17, Folder 19

Writings by others 1955 - 1975

Box 17, Folder 20

Thymidylate Synthetase - Amino acid sequences, correspondence, notes, and writings by others 1971 - 1986

 

Chemical and Product Information

Box 18, Folder 1

A to Z - Miscellaneous Product Information 1956 - 1987

Box 18, Folder 2

2-Amino-3-Phosphonopropionic Acid 1964 - 1984

Box 18, Folder 3

3T3 Cells - Henry (Enrique) Rozengurt publications 1975 - 1981

Box 18, Folder 4

Bakerbond Chiral Phase Columns - Correspondence, notes and product information ca. 1984

Box 18, Folder 5

Chemical Library Search Results (American Cancer Society) 1988

Box 18, Folder 6

Chemical requests - Correspondence to or from Friedkin regarding the acquisition of chemicals for research projects 1953 - 1983

Box 18, Folder 7

Difluoromethane-ornithine - Correspondence, notes and reprint 1989

Box 18, Folder 8

Dystrophin 1968 - 1988

Box 18, Folder 9

Fluoronucleotides 1983 - 1985

Box 18, Folder 10

Hept-6-yne-2,5-diamine 1983 - 1987

Box 18, Folder 11

Hydra-derived Inhibitors - Notes and photocopies of writings by others 1983 - 1985

Box 18, Folder 12

Inhibitory Effects of Aminoethyl Phophonate (AEP) - Correspondence with A. F. Isbell, notes and photocopies of writings by others 1959 - 1985

Box 18, Folder 13

IR and Molecular Ions - Mass spectra and mass chromatagrams undated

Box 18, Folder 14, Oversize FB-360-04

Laboratory equipment lists - Oversize 1988

Box 18, Folder 15

Liposomes 1969 - 1986

Box 18, Folder 16

Ornithine Decarboxylase - Notes and reprints 1974 - 1988

Box 18, Folder 17

Phthaloylamino Acids - Notes and photocopies of writings by others 1972 - 1983

Box 18, Folder 18

Phosphonopeptides 1978 - 1979

Box 19, Folder 1

Rubidium and Sodium Ions 1975 - 1980

Box 19, Folder 2

Tulp Sedementation Chamber - Graphs, photocopies of writings by others and photographs with negatives 1980 - 1985

 

Data and Laboratory Techniques

Box 19, Folder 3

2-Amino-4-Phosphono-Butyric Acid (APBA) - Graphs for poster undated

Box 19, Folder 4-5, Oversize FB-360-05

Aminophosphonocarboxylic Acid Compounds - Nuclear magnetic resonance spectra and correspondence with Jac L. Crase 1983

Box 19, Folder 6

Crawford, Elizabeth, Last experiment - Data, graphs and notes 1987

Box 19, Folder 7

Cronin, Maurin - Data ca. 1985

Box 19, Folder 8

Diethyl APPA (John Wright) - Data and nuclear magnetic resonance spectra 1979 - 1985

Box 19, Folder 9

Dimethyl Aminoethyl Phosphonate (AEP) Cyanoborohydride Products - Nuclear magnetic resonance spectra 1986

Box 19, Folder 10

Experiments 1058, 1065, 1074, 1079,1098 and 1111 - Data, HPLC printouts and spectrographs 1987

Box 19, Folder 11

Jackson, James - Notes and data 1980 - 1981

Box 19, Folder 12

L1210 +/- BUDr +/- Aminoethyl Phosphonate (Elizabeth Crawford) - Data, graphs and notes 1985

Box 19, Folder 13

Organic Synthesis - Notes and photocopies of writings by others 1941 - 1987

Box 19, Folder 14

Organic Synthesis Techniques (Frank H. Stodola) - Notes and reprints of writings by others 1942 - 1945

Box 19, Folder 15

Plante (Larry) Compounds - Summary undated

Box 19, Folder 16

Positron Emission Tomography - Photocopies and reprints of writings by others 1948 - 1987

Box 19, Folder 17

Procedure for Phosphate Determination 1977

Box 19, Folder 18

Protocol for the Prepartion of 3T3 Cell Extracts ca. 1979

Box 19, Folder 19

Proton Magnetic Resonance - Notes and photocopies of writings by others 1975 - 1988

Box 19, Folder 20

Redistilled Water Room at the Washington University School of Medicine - Drawing and photograph of redistillation apparatus 1958

Box 19, Folder 21

Resolution of Phosphono Compounds - Notes and photocopies of writings by others 1979 - 1984

Box 19, Folder 22

Ruthemeyer, Donna - Data Summary 1985

Box 19, Folder 23

Scintigraphy - Graphs 1977

Box 19, Folder 24

Thiouracil Deoxyriboside Crystals ca. 1954

Box 19, Folder 25

Use of Nuclear Magnetic Resonance Instrument at Brookhaven National Laboratory - Notes 1987

Box 19, Folder 26

X-ray Diffraction of Synthetic and Natural Thymidine - Data and x-ray images 1953

Box 19, Folder 27

Unidentified research images - Photographs and glass slide from Washington University Department of Illustrations undated

Box 20, Folder 1

Unidentified research materials - Chromatographs and x-ray films 1977

 

WRITINGS BY FRIEDKIN

 

Numbered Publications

Box 20, Folder 2

Publication list

Box 20, Folder 3-25, Oversize FB-360-06

1945 - 1975

Box 21, Folder 1-12, Oversize FB-360-07-09

1978 - 1986

Box 21, Folder 13

Unidentified negatives of figures undated

Box 21, Folder 14, Oversize FB-282-10

Unidentified figures - Oversize drawings and photoreproductions undated

 

Lectures

Box 21, Folder 15

Announcements - Miscellaneous 1957 - 1985

Box 21, Folder 16

Studies of Photosynthesis with Isotopes (Denmark) - Lecture typescript with figures 1949

Box 21, Folder 17

Desoxyranthosine - American Chemical Society (Chicago). Typescript 1950

Box 21, Folder 18

Enzymatic Synthesis of Thymidine - Lecture schedule, manuscript, figures, and reprints of writings by others 1951

Box 21, Folder 19

Synthesis of Thymidine - Manuscript 1951

Box 21, Folder 20

Azguania Nucleosides - Paper presented at the Federation Meeting. Manuscript 1952

Box 21, Folder 21

[Title unreadable] - Typescript 1952

Box 21, Folder 22

Untitled - Atlantic City lecture. Manuscript with figures 1962

Box 21, Folder 23

Biochemical Role of Vitamin B12 in Cellular Proliferation - Typescript of a lecture given by Friedkin at the IX Congresso da Sociedade Europeia de Hematologia 1963

Box 21, Folder 24

Morris Friedkin, et. al. Two-Enzyme Screen for the Design of New Folate Antagonists - Typescript ca. 1963

Box 21, Folder 25

Role of Folic Acid in Malaria - Manuscript and typescript 1968

Box 21, Folder 26

Structure and Function of Microtubules (Harvard University) - Notecards 1969

Box 21, Folder 27

Study of Folate Analogs (Faculty Seminar at UCSD) - Announcement and manuscript 1970

Box 21, Folder 28

Untitled (Hadassah Medical School Seminar) - Manuscript 1978

Box 21, Folder 29

Colchine Seminar - Manuscript 1980

Box 21, Folder 30

Role of Microtubules - Announcement and manuscript 1980

Box 21, Folder 31

Untitled lecture notes ca. 1992

Box 21, Folder 32

Ancient History of Thymidylate Synthetase - Typescript undated

Box 21, Folder 33

Use of Enzymens in the Design of New Drugs - Manuscript undated

Box 21, Folder 34

Untitled lecture on cytoplasmic microtubules - Notecards undated

 

Unnumbered Publications and Unpublished Writings

Box 21, Folder 35-36, Oversize FB-360-10

Attempted Block of De Novo Serine Biosynthesis by Inhibition of Phosphoserine Phosphatase 1983

Box 22, Folder 1

Morris Friedkin, et. al. Cell Cycle of L1210 Leukemia Cells is Blocked at G2/M by a Water-Soluable Polymer... 1988

Box 22, Folder 2

CERDLIN Paper 1987

Box 22, Folder 3

Class of 1968 - Tufts University School of Medicine Yearbook message 1968

Box 22, Folder 4

Conservation of Form in Water 1960

Box 22, Folder 5

Contrasting Styles with the Same Objective: Impressing Students with the Wonder of Life 1975

Box 22, Folder 6

Crystalline Desoxyribose-1-Phosphate ca. 1949

Box 22, Folder 7

Effects of 2micromolar Colchicine and 100 Ng/Ml Insulin on Cumulative Uridine Uptake undated

Box 22, Folder 8

Forty Years - Manuscript of a timeline of Friedkin's major research interests ca. 1982

Box 22, Folder 9

Friedkin, Morris, et. al. Tritium Isotope Effect During the Enzymic Synthesis of Thymidylate ca. 1967

Box 22, Folder 10-12, Oversize FB-360-11

Friedkin, Morris and Leslie Wilson. Microtubule Theory of Memory 1968

Box 22, Folder 13

New Genesis 1971

Box 22, Folder 14

Pharmacology - Tufts University School of Medicine Yearbook message 1961

Box 22, Folder 15

Preparation of Carbon-11 Labelled Thymidine ca. 1962

Box 22, Folder 16

Morris Friedkin, et. al. Process for the Production of 5'-Deoxy-5-[18F] Fluoridine - Patent application and correspondence with Brookhaven National Laboratory 1983

Box 22, Folder 17

Morris Friedkin and William Schwartz. Projection of Health Science Research Needs for the Tufts-New... ca. 1958 - 1969

Box 22, Folder 18

Revolution in Pharmacology 1960

Box 22, Folder 19

Morris Friedkin and Vincent Reid. Role of Folic Acid in Malaria 1967

Box 22, Folder 20

Rolling in Something Ripe... 1989

Box 22, Folder 21-23, Oversize FB-360-12

Studies on Aerobic Phosphorylation - Ph. D. dissertation 1947 - 1948

Box 23, Folder 1

Suggestions for Noah Freidkin (son) 1988

Box 23, Folder 2

Two-Enzyme Screen for the Design of New Folate Antagonists 1963

 

TEACHING AND ADMINISTRATIVE MATERIALS

 

Washington University School of Medicine

Box 23, Folder 3

Relationship of Vitamin B12 and the Deoxyribosides - Manuscript of a lecture for a biochemistry seminar 1949

Box 23, Folder 4

Quantitative Methods in Medicine - Course handouts, lecture manuscripts, examinations, and correspondence 1950 - 1958

Box 23, Folder 5

Physiology Seminar, B12 and Intrinsic Factors - Notecards and lecture manuscript 1951

Box 23, Folder 6

Washington University apartment lease 1950

Box 23, Folder 7

New Cold Room at the Washington University School of Medicine 1958

 

Tufts University School of Medicine

Box 23, Folder 8

Elementary Statistical Analysis for Use in Pharmacology - Course handouts and lecture manuscripts 1960

Box 23, Folder 9

Biology of Macromolecules Course: Learning and Memory - Lecture manuscript, reference list and reprints 1966

Box 23, Folder 10

Introduction to Biochemistry - Course handouts and lecture manuscript 1967

Box 23, Folder 11

Administrative documents - Includes Department of Pharmacology documents, Department of Biochemistry documents, A. Warren Stearns building information, and documents regarding Dean Haymen's retirement 1958 - 1969

Box 23, Folder 12

Nine Good Years - This document is a collection of articles produced by members of the Department of Pharmacology at Tufts University School of Medicine during Friedkin's time as chair of the department 1958 - 1967

Box 24, Folder 1-2

Yearbooks 1961 - 1966

Box 24, Folder 3

Tufts-New England Medical Center - Newspaper clippings 1966

Box 24, Folder 4

Yearbook 1967

 

Laboratory floor plans

Box 24, Folder 5

Includes Tufts University Department of Biochemistry floor plan, Tufts University Department of Pharmacology floor plan, and other unidentified floor plans 1967

Box 24, Folder 6, Oversize MC-154-04

Includes Tufts University Department of Biochemistry floor plan, blueprint of floor plan for Tufts College Medical and Dental School (194?), and other unidentified laboratory or building floor plans 1940 - 1967

 

UCSD School of Medicine

Box 24, Folder 7

Chemistry 219, Folic Acid Lectures - Lecture manuscripts, lecture schedule, course handout, and examination 1976

Box 24, Folder 8

Chemistry 269, Folic Acid Lectures - Lecture manuscripts 1970

Box 24, Folder 9

Carbon Dioxide History for Introduction to Biochemistry 105R - Lecture manuscript 1976 - 1978

Box 24, Folder 10

Suggestions for the Development of the Biomedical Program at San Diego - Manuscript, notes, correspondence, and newspaper clippings 1964

Box 24, Folder 11

Provost of Revelle College - Includes notes, typescripts, and letters to parents from the Provost 1974 - 1976

Box 24, Folder 12

Investigation of scientific misconduct - Includes Morris Friedkin and Suresh Subramani's notes on interviews with parties involved, photocopy of original complaint, correspondence and other related materials 1992

Conditions Governing Access note

Restrictions Apply
 

WRITINGS BY OTHERS

Box 25, Folder 1

A - Z - Miscellaneous 1936 - 1986

Box 25, Folder 2

Bobbs-Merrill Reprint Series in the Life Sciences 1952 - 1963

Box 25, Folder 3

Drew, Ruth M. and Robert B. Painter. "Action of Tritiated Thymidine on the Clonal Growth of Mammalian Cells" 1958

Box 25, Folder 4

Dicker, Phillip and Enrique Rozengurt. "Synergistic Stimulation of Early Events and DNA Synthesis by..." undated

 

Friedkin, Noah (son)

Box 25, Folder 5

"Formal Theory of Social Control" undated

Box 25, Folder 6

"Horizons of Observability and the Limits of Informal Control in Intraorganizational..." 1983

Box 25, Folder 7

"On the Origins and Prevalence of the Incest Taboo" undated

Box 25, Folder 8

Hanke, Martin E. Laboratory and Classroom Outline for Hydrogen Ion and Oxidation-Reduction Potentials 1939

Box 25, Folder 9, Oversize FB-360-13

Huang, Leaf and Richard E. Pagano. "Interaction of Phospholipid Vesicles with Cultured Mammalian Cells" 1975

Box 25, Folder 10

Hughes, W. L. "Chromosomal Replication and the Dynamics of Cellular Proliferation - Some Autoradiographic..." undated

Box 25, Folder 11

Levinson, Joel. "Photography of Anthony Friedkin" 1980

Box 25, Folder 12

Lomax, Nancita R. and V. L. Narayanan. "Chemical Structures of Interest to the Division of Cancer..." 1983

Box 25, Folder 13

Mackay, A. F. "Diazohydrocarbons" 1950

Box 25, Folder 14

Painter, R. B., et al. "Distribution of Tritium-labelled Thymidine in Escherichia Coli During Cell..." 1958

Box 25, Folder 15

Robertson, J. S. and W. L. Hughes. "Intra-Nuclear Irradiation with Tritium-labeled Thymidine" undated

Box 25, Folder 16

Sreevalson, T., et al. "Differential Effect of Interferon on DNA Synthesis 2-deoxyglucose Uptake and..." undated

Box 25, Folder 17

Wilson, Leslie. "Grasshopper Nueroblast Report." 1965

Box 25, Folder 18

Yorek, Mark A., et al. "Effect of Ethanolamine on Choline Uptake and Incorporation into..." undated

 

MISCELLANEOUS MATERIALS

Box 25, Folder 19

IX Congresso da Sociedade Europeia de Hematologia - Conference program, correspondence and notes 1963

Box 25, Folder 20

CERDLIN - A Potential Cancer Chemotherapeutic Agent Derived from Commercial Dowx 50 (Cation Exchange Resin) - Record of invention and correspondence 1986 - 1987

Box 25, Folder 21

Gordon Research Conferences - Includes conference booklets with notes 1966 - 1968

Box 25, Folder 22

International Convention of Biochemists (Bangalore) - Correspondence, convention materials and abstract of folic acid in malaria research 1967

Box 26, Folder 1

Malaria Conference (Walter Reed Army Institute of Research) - Correspondence, conference schedule and notes taken by Friedkin at the conference 1968

Box 26, Folder 2

Kaplan, Nathan O. Memorial materials - Correspondence and reprints of memorial articles from Analytical Chemistry 1986 - 1987

Box 26, Folder 3

Minutes of the Screening Committee for the California Division (American Cancer Society) 1978

Box 26, Folder 4

Newspaper clippings concerning others 1965 - 1986

Box 26, Folder 5

Oregon State Seminar - Notes and correspondence 1973

Box 26, Folder 6

Review of Graduate Pharmacology Program at the University of California, San Francisco - Correspondence, program guides and typescripts of review 1989

Box 26, Folder 7

Seventh International Congress of Biochemistry (Tokyo) - Correspondence and conference schedule 1967

Box 26, Folder 8

Slides - Miscellaneous undated

Box 26, Folder 9

Vietnam - Correspondence 1966

 

ORIGINALS OF PRESERVATION PHOTOCOPIES

Box 26, Folder 10

Originals of preservation photocopies