Harvey Itano Papers

Finding aid prepared by Special Collections & Archives
Special Collections & Archives, UC San Diego
9500 Gilman Drive
La Jolla, California, 92093-0175
858-534-2533
spcoll@ucsd.edu
Copyright 2005


Descriptive Summary

Title: Harvey Itano Papers
Identifier/Call Number: MSS 0226
Contributing Institution: Special Collections & Archives, UC San Diego
9500 Gilman Drive
La Jolla, California, 92093-0175
Languages: English
Physical Description: 3.8 Linear feet (10 archive boxes)
Date (inclusive): 1946 - 2000
Abstract: Papers of Harvey Itano, American biochemist and pioneer in the study of sickle cell anemia hematology. The collection documents Itano's research on sickle cell anemia disease and his work in the field of molecular medicine focusing on understanding of genetic and molecular basis of blood pathologies and hereditary diseases.
Creator: Itano, Harvey A.

Scope and Content of Collection

The papers of Harvey Itano, an American biochemist, document his pioneering research on sickle cell anemia and his work in the field of molecular medicine focusing on understanding of genetic and molecular basis of blood pathologies and hereditary diseases. Well represented in the papers are his laboratory notebooks and reprints of his journal publications. Of special interest are notebooks documenting his electrophoresis experiments that led to the discovery of a slight difference in electrophoretic mobility between normal and sickle cell hemoglobins and allowed him to explain the cause of the disease on a molecular basis. Also included are correspondence files with his colleagues in the field of molecular medicine, especially letters from Linus Pauling dating from 1946 to 1986.
The papers are arranged in five series: 1) MISCELLANEOUS MATERIALS, 2) CORRESPONDENCE, 3) NOTEBOOKS, 4) WRITINGS BY ITANO, and 5) MATERIALS RE: LINUS PAULING.
SERIES 1) MISCELLANEOUS MATERIALS
The MISCELLANEOUS MATERIALS series comprises materials providing biographical information and contains curriculum vitae with a list of publications, biographical forms, and articles mentioning Itano's work.
SERIES 2) CORRESPONDENCE
The CORRESPONDENCE series documents Itano's communication with colleagues in the field of molecular medicine. The materials are arranged in two subseries: A) Chronological Files and B) Alphabetical Files.
A) The Chronological Files (1969-1986) subseries primarily contains outgoing correspondence sent from Itano's office to his colleagues and professional journals.
B) The Alphabetical Files (1946-2000) subseries contains correspondence documenting Itano's election to the American Academy of Arts and Sciences and American Chemical Society, nomination to Martin Luther King Jr. Medical Achievement Award, letters from Linus Pauling, and correspondence with scholars who wrote about Pauling.
SERIES 3) NOTEBOOKS
The NOTEBOOKS subseries documents Itano's laboratory experiments and is arranged in five subseries: A) Composition Notebooks (1948-1986), B) Electrophoresis Experiments (1952-1953), C) Green Notebooks (1954-1969), D) Black Notebooks (1959-1976), and E) Brown Notebooks (1961-1962).
SERIES 4) WRITINGS BY ITANO
The WRITINGS BY ITANO subseries comprises of reprints of his journal publications. Also included is a copy of his Ph.D. dissertation and a few typescripts.
SERIES 5) MATERIALS RE: LINUS PAULING
Announcements and broadsides of events dedicated to Linus Pauling and photocopies of newspaper and magazine articles discussing life and work of Pauling.

Biography

Harvey Akio Itano was born on November 3, 1920, in Sacramento, California, the eldest son of Masao and Sumako (Nakahara) Itano. Itano attended University of California, Berkeley, and graduated in 1942 with highest honors in chemistry. Due to President Roosevelt's anti-Japanese campaign following Pearl Harbor, Itano with his family was sent to the desolate Tule Lake camp. While in the camp, Itano kept applying to medical schools throughout the country. With assistance from the National Japanese American Student Relocation Council, Itano was released from the camp to attend St. Louis School of Medicine. In 1945, Itano received his M.D. and continued Ph.D. studies at the California Institute of Technology in biochemistry where he studied and worked with Linus Pauling.
Itano is known for his pioneering work with sickle cell anemia disease, the topic assigned to him as a Ph.D. thesis topic by Linus Pauling. Sickle cell anemia disease is a hereditary disease commonly found among people of African descent. Itano tried several different physical and chemical methods to distinguish normal hemoglobin from sickle cell hemoglobin and finally he was able to demonstrate the difference by using electrophoresis. At that time, electrophoresis was a new technique that allowed researchers to separate molecules according to their electrical charge and Itano found a slight difference in electrophoretic mobility between normal and sickle cell hemoglobins. That led to understanding that patients with sickle cell anemia have a different type of hemoglobin than healthy individuals and thus a cause of a disease was traced to a molecule. Later, this inspired Vernon Ingram's seminal discovery of a single amino acid difference between normal and sickle cell hemoglobin and allowed him to explain a hemoglobin abnormality by an alteration in genes. After completing the project, Itano continued to work in the field of molecular medicine and published extensively about genetic and molecular basis of other blood pathologies and hereditary diseases.
Itano was awarded Eli Lilly Award in Biological Chemistry (1954) and Martin Luther King Jr. Medical Achievement Award (1972) for his pioneering work on sickle cell anemia disease. He is a member of the National Academy of Sciences (1979), American Academy of Arts and Sciences (1998), American Society of Biochemistry and Molecular Biology, Biochemistry Society (London), Phi Beta Kappa, Sigma Xi, and Alpha Omega Alpha.
Itano is professor emeritus in the Department of Pathology at UCSD and resides in La Jolla, California.

Publication Rights

Publication rights are held by the creator of the collection.

Preferred Citation

Harvey Itano Papers, MSS 226. Special Collections & Archives, UC San Diego.

Acquisition Information

Acquired 2004

Related Materials

Harvey Itano Personal Correspondence & Memorabilia, MSS 755. Special Collections & Archives, UC San Diego.

Subjects and Indexing Terms

Itano, Harvey A. -- Archives
Pauling, Linus, 1901-1994 -- Correspondence
Biochemistry

 

MISCELLANEOUS MATERIALS

Box 1, Folder 1

Biographical information

General note

Contains curriculum vitae, supplementary biographical forms, biography submitted for WHO'S WHO IN AMERICA, and photocopies of articles discussing Itano's work.
 

CORRESPONDENCE

 

Chronological Files

Box 1, Folder 2

1969-1971

Box 1, Folder 3

1972

Box 1, Folder 4

1973

Box 1, Folder 5

1974

Box 1, Folder 6

1975

Box 1, Folder 7

1976

Box 1, Folder 8

1977

Box 1, Folder 9

1978

Box 1, Folder 10

1979

Box 1, Folder 11

1980

Box 1, Folder 12

1981

Box 1, Folder 13

1982

Box 1, Folder 14

1983

Box 1, Folder 15

1984

Box 2, Folder 1

1985

Box 2, Folder 2

1986

General note

January - April.
Box 2, Folder 3

1986

General note

May - December.
 

Alphabetical Files

Box 2, Folder 4

American Academy of Arts and Sciences 1998

Box 2, Folder 5

American Chemical Society 2000

Box 2, Folder 6

Bengelsdorf, Irving S. 1994

Box 2, Folder 7

Goertzel, Victor 1980

Box 2, Folder 8

Heller, Paul 1994

Box 2, Folder 9

Linus Pauling Festschrift Volume 1966 - 1968

Box 2, Folder 10

Owen, Ray 1994 - 1995

Box 2, Folder 11

Pauling Kamb, Linda 1995

Box 2, Folder 12

Pauling, Linus 1946 - 1966

Box 2, Folder 13

Pauling, Linus 1969 - 1986

Box 2, Folder 14

Shellan, Jeffrey B. 1996

Box 2, Folder 15

Southern Christian Leadership Conference - Sickle Cell Anemia - Awards Banquet 1972

General note

Contains correspondence and biographical notes about Itano.
Box 2, Folder 16

University of California, Berkeley - Berkeley Convocation - Japanese American Alumni Association 1992

Box 2, Folder 17

Wills, Chris 1997

Box 2, Folder 18

Zewail, Ahmed H. 1989 - 1990

 

NOTEBOOKS

 

Composition Notebooks, 1948 - 1986

Box 2, Folder 19

1948

General note

Chemistry 259a.
Box 3, Folder 1

1950 - 1952

General note

Enzyme Kinetics, Physical Methods of Protein Chemistry.
Box 3, Folder 2

1952 - 1954

General note

51 Crellin.
Box 3, Folder 3

1972

Box 3, Folder 4

1972 - 1974

Box 3, Folder 5

1972 - 1974

Box 3, Folder 6

1973

Box 3, Folder 7

1973 - 1976

Box 3, Folder 8

1977

Box 4, Folder 1

1977 - 1979

Box 4, Folder 2

1979 - 1981

Box 4, Folder 3

1982 - 1986

 

Electrophoresis Experiments, 1952 - 1953

Box 4, Folder 4

August 13, 1952 - January 27, 1953

Box 4, Folder 5

October 16, 1952 - January 13, 1953

Box 4, Folder 6

January 16 - June 26, 1953

Box 4, Folder 7

January 28 - May 15, 1953

Box 4, Folder 8

April 30 - June 10, 1953

Box 4, Folder 9

May 18 - July 27, 1953

Box 4, Folder 10

August 24 - August 27, 1953

Box 5, Folder 1

October 6, 1953

Box 5, Folder 2

October 7, 1953

 

Green Notebooks, 1954 - 1969

Box 5, Folder 3

1954 - 1957

Box 5, Folder 4

1954 - 1967

Box 5, Folder 5

1955 - 1957

Box 5, Folder 6

1956 - 1958

Box 5, Folder 7

1958 - 1959

Box 6, Folder 1

1966

Box 6, Folder 2

1967

Box 6, Folder 3

1967 - 1968

Box 6, Folder 4

1969

Box 6, Folder 5

Undated

Box 7, Folder 1

Undated

 

Black Notebooks, 1959 - 1976

Box 7, Folder 2

Black Laboratory Book 1959 - 1961

Box 7, Folder 3

Black Laboratory Book 1962 - 1964

Box 7, Folder 4

Black Laboratory Book 1963 - 1965

Box 7, Folder 5

Black Laboratory Book 1964 - 1966

Box 8, Folder 1

Black Laboratory Book 1967

Box 8, Folder 2

Black Laboratory Book 1967 - 1968

Box 8, Folder 3

Black Laboratory Book 1972 - 1976

 

Brown Notebooks, 1961 - 1962

Box 8, Folder 4

1961 - 1962

Box 8, Folder 5

1962

 

WRITINGS BY ITANO

Box 8, Folder 6

Rapid Diagnostic Test For Sickle Cell Anemia 1949

General note

January. With Linus Pauling. Published in THE JOURNAL OF HEMATOLOGY, Vol. 14, No. 1. Contains reprint.
Box 8, Folder 7

Sickle Cell Anemia, a Molecular Disease 1949

General note

November 25. With Linus Pauling, S.J. Singer and Ibert C. Wells. Contains a reprint and a photocopy of the republished paper in SELECTED PAPERS ON MOLECULAR GENETICS, edited by J. Herbert Taylor, 1965.
Box 8, Folder 8

New Inherited Abnormality Of Human Hemoglobin 1950

General note

November. With James V. Neel. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
Box 8, Folder 9

Contributions To the Study Of Sickle Cell Hemoglobin 1950

General note

Ph.D. Thesis. Contains typescript.
Box 8, Folder 10

Ratio Of Sickle Cell Anemia Hemoglobin To Normal Hemoglobin In Sicklemics 1951

General note

January. With Ibert C. Wells. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 188, No. 1. Contains typescript.
Box 9, Folder 1

Familial Differences In the Proportion Of Abnormal Hemoglobin Present In the Sickle Cell Trait 1951

General note

October. With James V. Neel and Ibert C. Wells. Published in THE JOURNAL OF CLINICAL INVESTIGATIONS, Vol. XXX, No. 10. Contains reprint.
Box 9, Folder 2

Notes On a Proposed Therapeutic Program For Sickle Cell Anemia 1952

General note

January, 21. Contains typescript.
Box 9, Folder 3

Chronic Hemolytic Anemia Associated With Thalassemia and Sickling Traits 1952

General note

March. With Phillip Sturgeon and William N. Valentine. Published in THE JOURNAL OF HEMATOLOGY, Vol. VII, No. 3. Contains reprint.
Box 9, Folder 4

Third Abnormal Hemoglobin Associated With Hereditary Hemolytic Anemia 1951

General note

December. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 37, No. 12. Contains reprint.
Box 9, Folder 5

Hemolytic Anemia Presumably Due To Coexistence Of the Genes For Thalassemia and Sickling 1952

General note

With John S. Lawrence and James V. Neel. Published in TRANSACTIONS OF THE ASSOCIATION OF AMERICAN PHYSICIANS, Vol. LXV. Contains reprint.
Box 9, Folder 6

Human Hemoglobin 1953

General note

January, 30. Published in SCIENCE. Contains reprint.
Box 9, Folder 7

Electrophoretic Studies Of Globins Prepared From Normal Adult and Sickel Cell Hemoglobins 1953

General note

February. With E. Havinga. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
Box 9, Folder 8

Qualitative and Quantitative Control Of Adult Hemoglobin Synthesis - A Multiple Allele Hypothesis 1953

General note

March. Published in AMERICAN JOURNAL OF HUMAN GENETICS, Vol. 5, No. 1. Contains reprint.
Box 9, Folder 9

Two Cases Of Sickle Cell Disease Presumably Due to the Combination of the Genes For Thalassemia... 1953

General note

May. With James V. Neel and John S. Lawrence. Published in BLOOD, THE JOURNAL OF HEMATOLOGY, Vol. VIII, No. 5. Contains reprint.
Box 9, Folder 10

Solubilities Of Naturally Occuring Mixtures Of Human Hemoglobin 1953

General note

November. Published in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 47, No. 1. Contains reprint.
Box 9, Folder 11

Identification Of a Fourth Abnormal Human Hemoglobin 1954

General note

March 22. With W.R. Bergren and Phillip Sturgeon. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Contains reprint.
Box 9, Folder 12

Zone Electrophoresis Of Abnormal Hemoglobins 1954

General note

With William R. Bergren and Phillip Sturgeon. Published in ACTA HAEMATOLOGICA. Contains reprint.
Box 9, Folder 13

Clinical Manifestations Of Inherited Abnormal Hemoglobins 1955

General note

May. With Phillip Sturgeon and William R. Bergren. Published in THE JOURNAL OF HEMATOLOGY. Contains reprint.
Box 9, Folder 14

Genetic and Biochemical Studies Of "Intermediate" Types Of Cooley's Anemia 1955

General note

July. With Phillip Sturgeon and William R. Bergren. Published in BRITISH JOURNAL OF HAEMATOLOGY, Vol. 1, No. 3. Contains reprint.
Box 9, Folder 15

Clinical States Associated With Alterations Of the Hemoglobin Molecule 1955

General note

September. With Bethesda. Contains reprint.
Box 9, Folder 16

Abnormal Human Hemoglobins 1956

General note

May 2. With William R. Bergren and Phillip Sturgeon. Published in MEDICINE, Vol. 35, No. 2. Contains reprint.
Box 9, Folder 17

Hemoglobin J 1956

General note

May 18. With Oscar A. Thorup, Munsey Wheby and Byrd S. Leavell. Published in SCIENCE, Vol. 723, No. 3203. Contains reprint.
Box 9, Folder 18

Hyposthenuria In Sickle Cell Anemia: A Reversible Renal Defect 1956

General note

September. With H.G. Keitel and D. Thompson. Published in THE JOURNAL OF CLINICAL INVESTIGATION, Vol. XXXV, No. 9. Contains reprint.
Box 9, Folder 19

Demonstration Of Intermediate Forms Of Carbonmonoxy and Ferrihemoglobin... 1956

General note

November. With Elizabeth Robinson. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. Contains reprint.
Box 9, Folder 20

Hemoglobins 1956

General note

Published in ANNUAL REVIEW OF BIOCHEMISTRY, Vol. 25. Contains reprint.
Box 9, Folder 21

Hemoglobin Intermediates 1957

General note

March. With Elizabeth Robinson. Published in FEDERATION PROCEEDINGS, Vol. 16, No.1. Contains reprint.
Box 9, Folder 22

Electrophoretic Analyses Of the Abnormal Human Hemoglobins 1957

General note

May 2 - 3. Published in the PROCEEDINGS OF THE CONFERENCE ON HEMOGLOBIN. Contains reprint.
Box 9, Folder 23

Interpretation Of Electrophoretic, Solubility and Denaturation Data In the Study Of Hemoglobin Differences 1957

General note

September. Published in FEDERATION PROCEEDINGS, Vol. 16, No. 3. Contains reprint.
Box 9, Folder 24

Abnormal Hemoglobin Molecules In Relation To Disease 1957

General note

With Linus Pauling. Published in SATRYK URSVENSK KEMISK TIDSKRIFT. No. 69. Contains reprint.
Box 9, Folder 25

Human Hemoglobins: Their Properties and Genetic Control 1957

General note

Published in ADVANCES IN PROTEIN CHEMISTRY, Vol. XII. Contains reprint.
Box 9, Folder 26

Specificity In the Interaction Of Sickle Cell Hemoglobin Molecules 1957

General note

Published in MOLECULAR STRUCTURE AND BIOLOGICAL SPECIFICITY; Pub. No. 2. Contains reprint.
Box 9, Folder 27

On Dissociation and Recombination Of Human Adult Hemoglobins A, S and C 1958

General note

June. With S. J. Singer. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
Box 9, Folder 28

On the Asymmetrical Dissociation Of Human Hemoglobin 1958

General note

December 16. With S. J. Singer. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 45, No. 2. Contains reprint.
Box 9, Folder 29

Electrophoretic Separation Of Intermediate Compounds In Two Reactions Of Ferrihemoglobin 1958

General note

With E. Robinson. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 29. Contains reprint.
Box 9, Folder 30

Constituents Of Human Hemoglobin 1959

General note

June 27. With E. Robinson. Published in NATURE, Vol. 183. Contains reprint.
Box 9, Folder 31

Formation Of Normal and Doubly Abnormal Hemoglobins By Recombination Of Hemoglobin I With S and Cb 1959

General note

June 27. Published in NATURE, Vol. 183. Contains reprint.
Box 9, Folder 32

Properties and Inheritance Of Hemoglobin By Asymmetrical Recombination 1959

General note

November 7. With E. Robinson. Published in NATURE, Vol. 184. Contains reprint.
Box 9, Folder 33

Chemical and Genetical Units Of the Hemoglobin Molecule 1959

General note

With S. J. Singer and E. Robinson. Published in the Proceedings of Ciba Foundation Symposium on Biochemistry of Human Genetics. Contains typescript.
Box 9, Folder 34

Asymmetrical Recombination Of Alkali - Dissociated Hemoglobin Mixtures 1959

General note

February 20. With E. Robinson. Published in NATURE, Vol. 185, No. 4712. Contains reprint.
Box 9, Folder 35

Specific Recombination Of the Subunits Of Hemoglobin 1960

General note

August 31. With E. Robinson. Published in ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol. 88. Contains reprint.
Box 9, Folder 36

Genetic Control Of the Polypeptide Chains Of Hemoglobin 1960

General note

September 4 - 10. With E. A. Robinson. Published in the Proceedings of the VIIth International Congress of Hematology, held in Tokyo, Japan. Contains reprint.
Box 9, Folder 37

Genetic Control Of the Alpha and Beta Chains Of Hemoglobin 1960

General note

November. With Elizabeth A. Robinson. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 46, No. 11. Contains reprint.
Box 9, Folder 38

Identification Of the Recombinant Products Of Canine and Human Hemoglobins 1960

General note

December 3. With E. A. Robinson. Published in NATURE, Vol. 188, No. 4753. Contains reprint.
Box 9, Folder 39

Thalassemia and the Abnormal Human Hemoglobins 1961

General note

July 22. With Linus Pauling. Published in NATURE, Vol. 191, No. 4786. Contains reprint.
Box 9, Folder 40

Evidence For Coordination Of Monophenyl With Heme Proteins 1961

General note

With E. A. Robinson. Published in THE JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Vol. 83, No. 3339. Contains reprint.
Box 9, Folder 41

Blocking Of Tryptic Cleavage Of Arginyl Bonds By the Chemical Modification Of the Guanido Group With Benzil 1963

General note

With A. J. Gottlieb. Published in BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol. 12, No. 5. Contains reprint.
Box 9, Folder 42

Dissociation and Association Of Hemoglobin Subunits 1964

General note

With E. A. Robinson and A. J. Gottlieb. Published in SUBUNIT STRUCTURE OF PROTEINS BIOCHEMICAL AND PHYSICAL ASPECTS. Contains reprint.
Box 9, Folder 43

Chemical Modification Of Arginine With 1, 2 - Cyclohexanedione 1965

General note

August. With Koji Toi, Edward Bynum and Elaine Norris. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 240, No. 8. Contains reprint.
Box 9, Folder 44

Synthesis and Structure Of Normal and Abnormal Hemoglobins 1965

General note

From the National Institute of Arthritis and Metabolic Disease. Contains typescript, draft and reprint.
Box 9, Folder 45

Genetic Regulation Of Peptide Synthesis In Hemoglobins 1965

General note

June. Published in THE JOURNAL OF CELLULAR PHYSIOLOGY, Vol. 67, No. 3. Contains reprint.
Box 9, Folder 46

Phenanthrenequinone As an Analytical Reagent For Arginine and Other Monosubstituted Guanidines 1966

General note

August. With Shigeki Yamada. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 130. Contains reprint.
Box 9, Folder 47

Studies On the Chemical Modification Of Arginine 1967

General note

March 10. With Koji Toi, Edward Bynum and Elaine Norris. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 242, No. 5. Contains reprint.
Box 9, Folder 48

Protein - Protein Interaction Among Hemoglobin Subunits 1967

General note

March. With A. J. Gottlieb and E. Robinson. Published in ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Vol. 118, No. 3. Contains reprint.
Box 9, Folder 49

Primary Structure Of Hopkins - I Haemoglobin 1967

General note

April. WIth A. J. Gottlieb and E. A. Robinson. Published in NATURE, Vol. 214, No. 5084. Contains reprint.
Box 9, Folder 50

Chain Models Of 6.6 S and 3.9 S Mouse Myeloma Immunoglobulin Molecules 1968

General note

November. With T. Seki and E. Appella. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Contains reprint.
Box 9, Folder 51

Structure - Rate Hypothesis and the Toll Bridge Analogy 1968

General note

Contains offprint.
Box 9, Folder 52

Studies On the Quantitative Control Of Polypeptide Synthesis In Human Reticulocytes 1968

General note

With Haig H. Kazazian. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 243, No. 8. Contains reprint.
Box 9, Folder 53

Comparitive Structures Of A Immunoglobins 1969

General note

June 1 - 7. With E. Apella, T. Seki and E. A. Robinson. Presented at a Symposium on Developmental Aspects of Antibody Formation and Structure at the National Institute of Health in Maryland. Contains reprint.
Box 9, Folder 54

Introductory Speech For the Symposium On Metabolism Of Blood Pigment 1960

General note

September 4 - 10. Published in the Proceedings of the VIIIth International Congress of Hematology, held in Tokyo, Japan.
Box 9, Folder 55

Phenyldiimide, Hemoglobin, and Heinz Bodies 1970

General note

October. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 67, No. 2. Contains reprint.
Box 9, Folder 56

Moilar Extinction Coefficient Of Cyanmethemoglobin As Determined By Carbon Analysis 1971

General note

February. With W. M. Fogarty Jr. and W. C. Alford. Published in THE AMERICAN JOURNAL OF CLINICAL PATHOLOGY, Vol. 55, No. 2. Contains reprint.
Box 9, Folder 57

4 - Thialamine, a Strongly Basic Chemical Modification Of Cysteine 1972

General note

August 10. With Elizabeth A. Robinson. Published in THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 247, No. 15. Contains reprint.
Box 9, Folder 58

2 - Aminophenantromidazole, Flourescent Product Of the Reaction Of Phenanthrenequinone 1972

General note

August. With Shigeki Yamada. Published in ANALYTICAL BIOCHEMISTRY, Vol. 48, No. 2. Contains reprint.
Box 9, Folder 59

Methoanolysis Of the Pyrrolidone Of Amino - Terminal Pyroalutamic Acid In Model Peptides 1972

General note

August. Published in ANALYTICAL BIOCHEMISTRY, Vol. 48, No. 2. Contains reprint.
Box 9, Folder 60

Stoichiometry Of the Oxidation Of Arylhydrazines With Ferricyanide 1973

General note

June. With S. Mannen. Published in TETRAHEDRON, Vol. 29. Contains reprint.
Box 9, Folder 61

Delayed Removal Of N - Terminal Methionine From Nascent Global Chains In Sickle - Cell Anemia Reticulocytes 1973

General note

July. With Haruo Suzuki. Published in the PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 70, No. 7. Contains reprint.
Box 9, Folder 62

Quantitative Differences Between N - Terminal Methionyl Nascent Globin Chains Of Human and Rabbit Reticulocyte 1973

General note

November. Published in NATURE NEW BIOLOGY, Vol. 246, No. 152. Contains reprint.
Box 9, Folder 63

Alkaline Condensation Of 9, 10 - Phenanthrenedione With N, N - Dialkyguandines 1974

General note

December. Published in THE JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 11. Contains reprint and two requests for reprints.
Box 9, Folder 64

Absence Of Haemoglobin A In an Individual Simultaneously Heterozygous In the Genes For Hereditary.. 1974

General note

With W. M. Fogarty Jr. and T. S. Vedvick. Published in THE BRITISH JOURNAL OF HAEMATOLOGY, Vol. 26. Contains reprint.
Box 9, Folder 65

Effect Of Ring Substitution On the Hemolytic Action Of Arylhdrazines [38904] 1974

General note

With David W. Hollister, William M. Fogarty, Jr. and Shigeyasu Mannen. Published in PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 147. Contains reprint.
Box 9, Folder 66

Solubility Changes In Sickle Cell Hemoglobin As the Amino Groups are Carbamylated [38321] 1974

General note

With T. S. Vedvick and H. M. Koenig. Published in the PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 147. Contains reprint.
Box 9, Folder 67

Mechanism Of Induction Of HÅ“molytic Anaemia By Phenylhydrazine 1975

General note

August 21. Published in NATURE, Vol. 256, No. 5519. Contains reprint.
Box 9, Folder 68

Deoxhemoglobin S : Solubility Vs. Erythrocyte Sickling 1975

General note

With T. S. Vedvick and H. M. Koenig. Published in CLINICAL BIOCHEMISTRY, Vol. 8. Contains reprint.
Box 9, Folder 69

Induction Of Haemolytic Anaemia By Substituted Phenylhydrazines 1975

General note

With K. Hosokawa and K. Hirota. Published in THE BRITISH JOURNAL OF HAEMATOLOGY, Vol. 32, No. 99. Contains reprint.
Box 9, Folder 70

Reactions Of Phenyldiazene and Ring - Substituted Phenyldiazenes With Ferrihemoglobin 1975

General note

With Shigeyasu Mannen. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 421. Contains reprint.
Box 9, Folder 71

Topics In Hematology 1976

General note

September. Published in Excerpta Medica International Congress Series, No. 415. Contains reprint.
Box 9, Folder 72

In Vitro Translation Of Globin: Effect Of Proteins Purified By Affinity Chromatography On Polyadenylate.. 1976

General note

With Hiroichi Fukami. Published in BIOCHEMISTRY, Vol. 15, No. 3529. Contains reprint.
Box 9, Folder 73

Mechanism and Specifity Of the Phenanthrenequinone Test for Monosubstituted Guanidines 1976

General note

With Kazuhiro Hirota, Ichiro Kawasaki and Shigeki Yamada. Published in ANALYTICAL BIOCHEMISTRY, Vol. 76. Contains reprint.
Box 9, Folder 74

Partial Characterization Of the Hemoglobin From Hubb's Beaked Whale 1976

General note

With T. S. Vedvick. Published in COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY, Vol. 55B. Contains reprint.
Box 9, Folder 75

Liglands and Oxidants In Ferrihemochrome Formation and Oxidative Hemolysis 1977

General note

June. With Kazuhiro Hirota and Thomas Vedvick. Published in PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, Vol. 74, No. 6. Contains reprint and typescript of adresses.
Box 9, Folder 76

Influence Of Ring Substitutes On the Binding Of Nitrosobenzene By Ferrohemoglobin 1978

General note

May. With Kazuhiro Hirota. Published in THE JOURNAL OF BIOCHEMISTRY, Vol. 253, No. 10. Contains reprint.
Box 9, Folder 77

Oxidative Degradation Of Haemoglobin By Nitrosobenzene In the Erythrocyte 1978

General note

With Kazuhiro Hirota and Thomas S. Vedvick. Published in THE BIOCHEMISTRY JOURNAL, Vol. 174. Contains reprint.
Box 9, Folder 78

Initiation Of Fetal Hemoglobin Biosynthesis 1979

General note

With Hitoshi Imanishi and Haruo Suzuki. Published in BIOCHIMICA ET BIOPHYSICA ACTA, Vol. 564. Contains reprint.
Box 9, Folder 79

Induction Of Anemia In Spelnectomized and Nonsplenectomized Rats 1980

General note

With Thomas S. Vedvick. Published in PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, Vol. 163. Contains reprint.
Box 9, Folder 80

Further Studies On the Chemical Modification Of Arginine

General note

Undated. Contains one page typescript.
Box 9, Folder 81

Genetic and Physical Factors In the Meterogeneity Of Hemoglobin

General note

Undated. Contains reprint.
Box 9, Folder 82

Interpretation Of Data On Haemoglobin Heterogeneity

General note

Undated. Contains reprint.
Box 9, Folder 83

Sensitive Test For Arginine and Other Guanido Compounds

General note

Undated. Contains one page typescript.
 

MATERIALS RE: LINUS PAULING

Box 10, Folder 1

Announcements and broadsides of events with participation of Linus Pauling or dedicated to him 1946 - 1994

Box 10, Folder 2

Newspaper and magazine articles about Pauling 1946 - 1998