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Donald F. Klein papers, circa 1960s-2005
1242
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Title: Donald F. Klein papers
Collection number: 1242
Contributing Institution:
UCLA Library Special Collections for Medicine and the Sciences
Language of Material:
English
Physical Description:
36.8 linear ft.
(34 record storage cartons, 4 document boxes and 6 half document boxes)
Date: circa 1960s-2005
Abstract: Donald Franklin Klein, Professor emeritus in the Department of Psychiatry at Columbia University College of Physicians and
Surgeons, is a psychiatrist and researcher who revolutionized psychiatric thinking through his discovery in 1960 that imipramine,
a recently-developed psychotropic medication, was effective in blocking panic attacks. The collection consists of correspondence,
subject files, American College of Neuropsychopharmacology (ACNP) committee files, grant applications, research projects,
publications, video and audiotapes, awards, certificates and biographical sketches related to Klein's work as a founder of
modern psychopharmacology.
Physical Location: Stored off-site at SRLF. Advance notice is required for access to the collection. Please contact the History and Special Collections
for the Sciences, Louise M. Darling Biomedical Library Reference Desk for paging information.
Creator:
Klein, Donald F., 1928-
COLLECTION STORED OFF-SITE AT SRLF: Open for research. Advance notice required for access. Contact the History and Special
Collections for the Sciences, Louise M. Darling Biomedical Library Reference Desk for paging information. Series 3, Boxes
28-32: Restricted access; apply to History and Special Collections for the Sciences, Louise M. Darling Biomedical Library
at least one month in advance of a research visit, so confidential identification material may be redacted. Series 4, Boxes
35-39: Restricted access and use because of patient/subject names and personally identifiable information; this material is
closed until further notice, pending consultation with campus counsel about policies and procedures for access and use.
Restrictions on Use and Reproduction
Property rights to the physical object belong to the UCLA Library Special Collections. Literary rights, including copyright,
are retained by the creators and their heirs. It is the responsibility of the researcher to determine who holds the copyright
and pursue the copyright owner or his or her heir for permission to publish where The UC Regents do not hold the copyright.
[Identification of item], Donald F. Klein Papers (Biomed Manuscript Collection Number 1242), UCLA Library Special Collections,
History and Special Collections for the Sciences, Louise M. Darling Biomedical Library.
Provenance/Source of Acquisition
Donald F. Klein donated to Vanderbilt University Medical Library; Klein's papers and other American College of Neuropsychopharmacology
(ACNP) collections were transferred to UCLA Library Special Collections, through the UCLA Neuroscience History Archives, on
1 July 2008. Klein's collection forms part of UCLA/ACNP History of Neuropsychopharmacology Archives.
Processed by Kelly Besser, with assistance from Rebecca Bucher, in consultation with curator Russell Johnson and under supervision
of Megan Hahn Fraser, 2013.
Donald Franklin Klein was born in New York City on September 4, 1928. He attended the Bronx High School of Science, and received
his Bachelor of Arts degree,
magna cum laude, from Colby College in Waterville, Maine in 1947. He then attended the New York University Graduate Program in Biology from
1947-48 and received his M.D. degree from the State University of New York, College of Medicine in 1952.
After completing his psychiatric residency at Creedmor State Hospital, Dr. Klein became a Research Associate at the Creedmor
Institute for Biological Studies. In 1959, he moved to Hillside Hospital where he eventually became Medical Director for Research
and Evaluation and Psychiatrist-in-Chief of the affiliated Queens Hospital Center. Dr. Klein's 1960 discovery that the drug
imipramine had an anti-panic effect not only led to helpful treatments, but also eventually defined a disorder and introduced
the concept of the biological bases of psychiatric illness.
Dr. Klein joined the faculty of the Department of Psychiatry at the College of Physicians and Surgeons of Columbia University
in 1976. He has served as Attending Psychiatrist at the Presbyterian Hospital and Director of Psychiatric Research and Therapeutics
at the New York State Psychiatric Institute. Since 1976, Dr. Klein has been a leading investigator of the phenomenology, biology
and treatment of panic disorder.
Dr. Klein is considered a founder of modern psychopharmacology and the first to rigorously demonstrate the efficacy of antidepressants
for panic disorder patients. He also co-authored the first textbook of clinical psychopharmacology,
Diagnosis and Drug Treatment in Psychiatric Disorders in 1969. This book played a major role in the move towards systematic objective diagnosis in psychiatry. Additionally, he
was a leading contributor to the third edition of the
Diagnostic and Statistical Manual of Mental Disorders (DSM-III) in 1980, which ushered in the age of modern psychiatry.
He is Past President of the American College of Neuropsychopharmacology (ACNP), the National Foundation for Depressive Illness,
Psychiatric Research Society, the American Psychopathological Association and the American Society of Clinical Psychopharmacology
which he co-founded in 1992. Dr. Klein has held several federal grants and has also served as a federal consultant for a number
of important agencies including the Neuropharmacology Advisory Committee of the Food and Drug Administration, the Center for
Studies of Narcotic and Drug Abuse and the Clinical Psychopharmacology Study Section of the National Institute of Mental Health.
Dr. Klein’s scientific work has focused on the evaluation of psychiatric therapies, both psychotherapeutic and pharmacotherapeutic.
He has contributed to psychiatric nosology and differential indications for treatment in the areas of panic disorder, agoraphobia,
simple and social phobias, endogenomorphic and atypical depression, childhood asocial schizophrenia, attention deficit disorder
and anxiety disorders. He is Professor emeritus in the Department of Psychiatry at Columbia University College of Physicians
and Surgeons.
The collection consists of correspondence, subject files, American College of Neuropsychopharmacology (ACNP) committee files,
grant applications, research projects, publications, videotapes, audiotapes, awards, certificates and biographical sketches
related to the scientific career of Dr. Donald F. Klein. It includes patient files related to Klein's seminal drug therapy
studies conducted at Long Island Jewish-Hillside Hospital during which he began exploring pharmacological solutions to treating
panic disorders.
This collection has been arranged in the following series:
- Series 1: Correspondence and Subject Files.
- Series 2: American College of Neuropsychopharmacology Committee Files.
- Series 3: Grants.
- Series 4: Research Projects.
- Series 5: Publications.
- Series 6: Video and Audiotapes.
- Series 7: Awards, Certificates, Nominations and Biographies.
UCLA Catalog Record ID:
7151631