Kenneth E. Livingston Papers. Supplement. 1952-1984

Processed by UCLA Biomedical Library staff; machine-readable finding aid created by Caroline Cubé.
Louise M. Darling Biomedical Library History and Special Collections for the Sciences
History and Special Collections Division for the Sciences
UCLA
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The Regents of the University of California. All rights reserved.


Descriptive Summary

Title: Kenneth E. Livingston Papers. Supplement.,
Date (inclusive): 1952-1984
Collection number: 130.1
Creator: Livingston, Kenneth E. 1914-1984
Extent: 2 cartons (2.0 linear ft.)
Repository: University of California, Los Angeles. Library. Louise M. Darling Biomedical Library History and Special Collections for the Sciences
Los Angeles, California 90095-1490
Abstract: The supplement to the main Kenneth E. Livingston collection (Ms. Collection #130) extends the documentation of his clinical and research endeavors in limbic system research and in the control of chronic pain. To his long-term ongoing study of intravenous procaine for pain control, Dr. Livingston added a small clinical trial on the efficacy of oral tocainide and was much excited by the results; this later interest is well covered in these supplemental materials. There are also drafts of ideas and letters concerning his thoughts on ecology, homeostasis and the brain-mind discussion. All the Kenneth E. Livingston papers are part of the John C. Liebeskind History of Pain Collection at UCLA.
Physical location: Southern Regional Library Facility (SRLF)
Language of Material: Collection materials in English

Access

The Collection is open for research, but access to some materials is restricted due to patient confidentiality protocols.

Preferred Citation

[Identification of item], Kenneth E. Livingston Papers. Supplement (Manuscript collection 130.1). Louise M. Darling Biomedical Library History and Special Collections for the Sciences, University of California, Los Angeles.

Acquisition Information

Gift of Mrs. Katherine Livingston, 1998.

Biography

Kenneth Edwin Livingston was born in 1914, in Pendleton, Oregon and died in Camp Sherman, Oregon, in 1984. He attended Stanford University (BA, 1936) and Harvard Medical School (MD, 1939), and finished his specialization in Neurosurgery at the Lahey Clinic, Boston. After service in the U.S. Navy Medical Corps during World War II he returned to the Lahey Clinic until 1948, when he relocated to Oregon. In 1960 he was invited to Shiraz University in Iran to develop the Neurosurgery Service at Nemazee Hospital, and in 1962 was appointed Visiting Dean at Pahlavi University to develop their Medical School under an USAID program. For a year after his return to the U.S. in 1966 Dr. Livingston served as a Consultant to the Department of Health, Education, and Welfare, and in 1968 he became Professor of Surgery/Neurosurgery at the University of Toronto and Chief of Neurosurgery at Wellesley Hospital. He served these institutions until his retirement in 1981.
Dr. Livingston and his Wellesley group did important research in limbic lobe mechanisms, temporal lobe epilepsy and drug addiction. But it was the question of pain, what it was and how to ameliorate it, that mainly occupied his mind and activities in later years. In this interest he followed his father, William K. Livingston, a renowned neurosurgeon who was equally interested in the problem of pain.

Scope and Content

The papers augment, and may occasionally duplicate, the documents in the main collection (Ms. Coll. no. 130). They include material on Dr. Livingston's limbic system research, and especially on his ongoing studies in the control of chronic pain. A number of drafts report on his use of procaine injections to treat patients with intractable pain, and on the possible CNS mechanisms that might explain the drug's results. In his last years before retirement Dr. Livingston ran a small clinical trial using oral tocainide for pain control and was impressed by the results. This supplement includes his reports on the tocainide trial and his future plans for the drug's use. It also includes a few of his essays and musings on broader questions of biology and society.
The collection is organized into the following series:
  • Series 1. Professional Papers, 1952-1984 . 34 folders
  • Series 2. Patients, 1970-1982. 19 folders
  • Series 3. Miscellaneous, 1957-1984. 5 folders

Related Material

"Register of the Kenneth E. Livingston Papers, 1935-1984". UCLA Biomedical Library Ms. Coll. #130. 22 boxes
"Register of the William K. Livingston Papers, 1923-1966". UCLA Biomedical Library Ms. Coll. #136. 5 boxes

UCLA Catalog Record ID

UCLA Catalog Record ID: 7386844 

Indexing Terms

The following terms have been used to index the description of this collection in the library's online public access catalog.

Subjects

Livingston, Kenneth E .
Neurosurgery
Pain
Procaine -- therapeutic use
Tocainide -- therapeutic use.


 

Series 1. Professional Papers. 1952-1984.

Physical Description: 34 folders
box 1, folder 1

Curriculum vitae and Bibliography. 1980.

box 1, folder 2

Department of Health, Education, and Welfare. 1966-1967.

Scope and Content Note

correspondence with Philip R. Lee, M.D., Asst. Secretary for Health and Scientific Affairs, and other scientists

Note

KEL served one year as a consultant to the Office of the Secretary for such topics as international health, health manpower, neurological trauma, and narcotic addiction and drug abuse
box 2, folder 1

The chronic psychiatric patient and psychiatric services today. 1973-1978.

Scope and Content Note

extensive materials gathered for a proposed monograph on chronic psychiatric patients - EEG studies, neurological and neurosurgical perspectives, physical status

Note

RESTRICTED for patient confidentiality
box 1, folder 3

"The surgery of affective disorders". undated.

Scope and Content Note

thirty-page typed manuscript
box 1, folder 4

Limbic system concept - drafts and notes. 1968- circa 1973.

Scope and Content Note

typed drafts, including presentations at Cushing Society and Poppen Symposium; handwritten drafts and notes

Note

for related material, see main collection Ms.Coll. #130, Box 9 - Folder 5
box 1, folder 5

Limbic lobe - bibliographic notes. undated.

Scope and Content Note

handwritten notes on readings, and bibliographic lists
box 1, folder 6

Symposium: "The continuing evolution of the limbic system concept", Toronto, Nov. 5-6, 1976. 1976.

Scope and Content Note

typed copies of four papers presented by Paul D. MacLean, Walle J.H. Nauta, Lennart Helmer, and Paul I. Yakovlev (as told to and introduced by Kenneth E. Livingston); miscellaneous correspondence and announcements regarding the symposium

Note

proceedings of the meeting were published as " Limbic mechanisms: the continuing evolution of the limbic system concept", ed. by Kenneth E. Livingston and Oleh Hornykiewicz. New York: Plenum Press, c1978; the meeting was often referred to as "The 2nd Limbic System Conference"
box 1, folder 7

Correspondence with Paul I. Yakovlev. 1952-1983.

Scope and Content Note

extensive correspondence; ongoing topics: 1. preservation of the papers and scientific memorabilia of James W. Papez, including an application for funds to the Hanna Foundation, 1978, to organize the collection; 2. evolving concepts of various brain systems, especially the limbic; 3. discussion of plans for the 2nd [1976] and 3rd [1983] Limbic System Conferences and Dr. Yakovlev's participation in them; also included: photocopy of an 1944 letter from Dr. James W. Papez to Dr. Yakovlev describing the composition of the stria medullaris thalami; a list compiled by KEL of Yakovlev's personal scientific library

Note

a few letters from other correspondents are included
box 1, folder 8

"The continuing evolution of the limbic system concept", by KEL and Alfonso Escobar. . undated.

Scope and Content Note

five-page typed manuscript
box 1, folder 9

Kindling. 1978, 1981, undated.

Scope and Content Note

reprint from "Limbic Mechanisms"; miscellaneous correspondence and notes

Note

file title copied from original folder; for related material, also see main collection Ms.Coll. #130, Box 1 - Folder 21, Box 7 - Folder 38, Box 9 - Folder 12
box 1, folder 10

International Symposium on Patterns of Limbic System Dysfunction, 3rd, Toronto, May 8-10, 1983. 1982-1983.

Scope and Content Note

planning notes; symposium program and list of registrants; correspondence regarding organization, and reports of the meeting's success sent to KEL and his wife

Note

KEL planned and organized the symposium, but was unable to attend because of illness. The papers were published as: "The Limbic system : functional organization and clinical disorders", ed. by Benjamin K. Doane and Kenneth E. Livingston N.Y., Raven Press, 1986
box 1, folder 11

Limbic Mechanisms Research Program. 1975-1982.

Scope and Content Note

"The limbic mechanisms research program, 1967-1982", three pages describing KEL's involvement, prepared for a report or proposal; summary nine-page progress report, Oct. 1st, 1975, signed by KEL; newspaper article
box 1, folder 12

Limbic Mechanisms Research Foundation. 1982.

Scope and Content Note

Memorandum, 1982; Report to the Board, 1982, plus Addendum

Note

see also Box 1, Folder 20
box 1, folder 13

"The problem of central modulatory control". undated.

Scope and Content Note

three-page typed draft of a grant proposal - funding agency not specified
box 1, folder 14

"Temporal lobe epilepsy - a persisting enigma: new strategies for diagnosis and treatment derived from basic research". 1980.

Scope and Content Note

grant application to the Connaught Fund; background materials

Note

for related material, see main collection Ms.Coll. #130, Box 3 - Folder 14
box 1, folder 15

"A new approach to the management of chronic intractable pain secondary to advanced malignant disease: a clinical trial - the Princess Margaret Hospital". undated.

Scope and Content Note

five-page typed proposal
box 1, folder 16

Seminar/workshops on chronic pain. 1978, 1981.

Scope and Content Note

programs, correspondence, and notes for two workshops: 1. Princess Margaret Hospital, Toronto, 1979; 2. Saint John, New Brunswick, 1981

Note

for related material, see main collection Ms.Coll. #130, Box 5 - Folder 30
box 1, folder 17

"The intractable pain of advanced cancer: a new approach to management". undated.

Scope and Content Note

17-page draft of a paper intended for the "New England Journal of Medicine", plus comments from an informal reviewer

Note

for related material, see main collection Ms.Coll. #130, Box 9 - Folders 35 & 38
box 1, folder 18

"Cancer pain: a new approach to the management of intractable pain". 1981-1982.

Scope and Content Note

grant applications to: 1. The Ontario Cancer Treatment and Research Foundation; 2. The National Cancer Institute of Canada; correspondence

Note

the two applications are essentially identical
box 1, folder 19

Procaine - narcotic addiction and other potential clinical uses. 1980 -1981, undated.

Scope and Content Note

proposal for "A Study of the ameliorating effects of intravenous procaine on narcotic addiction secondary to chronic intractable pain, by P. Carlen,...K. Livingston,..." - to be carried out with Addiction Research Foundation Clinical Inst.(ARF), Toronto, patients; proposal by KEL for a study of procaine in rat brain, to be carried out in ARF labs; KEL draft about potential procaine uses in drug addiction, emphysema, and other clinical syndromes; letter from ARF
box 1, folder 20

Procaine - KEL's writings. undated.

Scope and Content Note

short drafts: description of the drug, its history, metabolism and CNS effects; the problem of chronic pain; clinical trials of procaine for pain relief: protocol, case summaries of use in malignant and non-malignant patients

Note

file title copied from original folder; for related material, also see main collection Ms.Coll. #130, Box 17 - Folder 22
box 1, folder 21

Procaine - research - Pablo. circa 1979-1981.

Scope and Content Note

c.v. for Pablo Sanhueza, M.D.; short KEL handwritten texts on procaine experiments in animals; notes; some articles focusing on the drug mexiletine

Note

folder title taken from original folder
box 1, folder 22

Procaine notebook: Limbic Mechanisms Research Foundation - [the Red Notebook]. circa 1981-1982.

Physical Description: spiral bound notebook

Scope and Content Note

a well-organized report of the entire series of procaine pain studies, from "The problem of chronic pain" to clinical data and case histories, to "Unfinished business", prepared for the Limbic Mechanisms Research Foundation

Note

most of the content duplicates documents in the above "Procaine" folders; see related notebook [the Blue Notebook] in Box 1 - Folder 27
box 1, folder 23

Procaine - general. 1972-1981.

Scope and Content Note

notes; reprints from other authors
box 1, folder 24

Lidocaine. 1971, 1982.

Scope and Content Note

photocopy of "General pharmacology and toxicology of lidocaine", by Arne Astrom, in: "Lidocaine in the treatment of ventricular arrhythmias", proceeding of a symposium, Edinburgh, 1970, ed. by D.B. Scott and D.G. Julian. Edinburgh: Livingstone, 1971; typed list: "ASTRA scientists, 1971"; two-page chronology, "The lidocaine timetable", by KEL, 1982
box 1, folder 25

Tocainide and pain. 1981.

Scope and Content Note

history and description of tocainide; its potential for relief of persistent pain; proposal for a small clinical trial and letters of institutional approval; softbound manual,"Tocainide: investigator's brochure", issued by Astra Pharmaceuticals Canada Ltd.
box 1, folder 26

Tocainide clinical trial. 1981.

Scope and Content Note

descriptions of the small tocainide clinical trial; extensive case summaries, illustrations and graphs; comparison with procaine treatment in some patients

Note

some overlap with the "Blue" notebook
box 1, folder 27

Tocainide - Limbic Mechanisms Research Foundation - [the Blue Notebook]. 1982.

Physical Description: spiral bound notebook

Scope and Content Note

loose-leaf notebook with information for the Foundation, whose goal was "...to provide adequate and continuing financial support for highly potential medical research.... The Foundation is to acquire patents on certain existing results of the research, to license the patents to a major pharmaceutical company..."; typed status report on nine donors; some correspondence; photocopy of a special report from "The New England Journal of Medicine": "Taking university research into the marketplace".

Note

some overlap with Box 1 - Folder 26; see also "Red" Notebook, Box 1 - Folder 21
box 1, folder 28

Tocainide - Patent application for "Methods of treating intractable pain". 1981-1984.

Scope and Content Note

extensive correspondence regarding the patent application for a new use of the drug tocainide, in pain control; consideration of setting up a Limbic Mechanisms Research Foundation for the financing of further research with this drug

Note

see Box 1 - Folders 12, 21, and 27 for more on the Foundation; see also main collection Ms.Coll. #130, Box 9 - Folders 35,38, Box 2 - Folder 1
box 1, folder 29

Tocainide patent. 1981-1983.

Scope and Content Note

extensive notes; invoices for legal work
box 1, folder 30

Man - Earth - Ecology. 1978, 1981, undated.

Scope and Content Note

nine-page manuscript, "The growing crisis of planet earth: a discussion of the brain as a model for global ecology"; six-page notes for a presentation, Boston, August 21, 1978; five-page notes for presentation, 1981; additional notes and newspaper clippings; letter exchange with Paul MacLean; readings

Note

for related material, see main collection Ms.Coll. #130, Box 6 - Folder 8
box 1, folder 31

Ideas. 1962-1981.

Scope and Content Note

contents of 2 folders with that label: 1. drafts and notes on "A proposal for the development of a major experimental laboratory at The Wellesley Hospital"; 2. draft of "U.S. bombs for peace", a proposal to use bomb nuclear packages in power plants, with a letter to Albert Szent-Gyorgi; 3. several proposals of programs for a radio/TV? show named IDEAS, including text of a 1981 paper KEL presented to the American Association for the History of Medicine; 4. discussions from two seminars with senior medical students about medical education

Note

see also folder on Ecology, Box 1 - Folder 31; for related material, see main collection Ms.Coll. #130, Box 8 - Folder 28
box 1, folder 32

Homeostasis. undated.

Scope and Content Note

contents of 3 folders with that label: 1. handwritten notes on readings, from Nauta, Starling, Fulton, Carmon; 2. hand-written and typed notes and drafts concerning function of the brain; 3. hand-written and typed notes and drafts concerning man, nature, and their relationship

Note

see also Box 1 - Folder 4 "The central modulation of visceral homeostatic mechanisms: a contribution to limbic theory"; for other related material, see main collection Ms.Coll. #130, Box 8 - Folder 32
box 1, folder 33

Grants - financial balances. 1978-1981.

Scope and Content Note

monthly balances for all ongoing projects [some changes over time]

Note

for related materials, see main collection Ms.Coll. #130 - many entries
 

Series 2. Patients. 1970-1982.

Scope and Content Note

Access to patient files is RESTRICTED. Most files contain: KEL's examination notes; patients' notes on their pain, activity, and emotional status; hospital and laboratory notes and reports; correspondence with referring physicians, insurance companies, or government agencies; many files have a handwritten case summary.

Arrangement

Alphabetical within each sub-series.
 

Subseries 1. Procaine Series

Physical Description: 18 folders

Arrangement

alphabetical in separate non-malignant and malignant series
box 2, folder 2

Patients: A. 1975-1979.

Scope and Content Note

3 records

Note

RESTRICTED
box 2, folder 3

Patients: B. 1971-1982.

Scope and Content Note

8 records

Note

RESTRICTED
box 2, folder 4

Patients: C. 1973-1981.

Scope and Content Note

6 records

Note

RESTRICTED
box 2, folder 5

Patients: D. 1977-1978.

Scope and Content Note

5 records

Note

RESTRICTED
box 2, folder 6

Patients: E-G. 1977-1981.

Scope and Content Note

4 records

Note

RESTRICTED
box 2, folder 7

Patients: H-I. 1977-1981.

Scope and Content Note

4 records

Note

RESTRICTED
box 2, folder 8

Patients: J-K. 1973-1978.

Scope and Content Note

5 records

Note

RESTRICTED
box 2, folder 9

Patients: L-N. 1975-1981.

Scope and Content Note

6 records

Note

RESTRICTED
box 2, folder 10

Patients: O-P. 1975-1981.

Scope and Content Note

5 records

Note

RESTRICTED
box 2, folder 11

Patients: Ra-Ri. 1975-1980.

Scope and Content Note

11 records

Note

RESTRICTED
box 2, folder 12

Patients: Ro-Ru. 1973-1979.

Scope and Content Note

6 records

Note

RESTRICTED
box 2, folder 13

Patients: Sa-Se. 1970-1979.

Scope and Content Note

5 records

Note

RESTRICTED
box 2, folder 14

Patients: Sh-St. 1972-1979.

Scope and Content Note

8 records

Note

RESTRICTED
box 2, folder 15

Patients: T. 1973-1981.

Scope and Content Note

6 records

Note

RESTRICTED
box 2, folder 16

Patients: V. 1971-1979.

Scope and Content Note

3 records

Note

RESTRICTED
box 2, folder 17

Patients: W. 1974-1982.

Scope and Content Note

9 records

Note

RESTRICTED
box 2, folder 18

Patient diaries. 1982.

Scope and Content Note

ongoing notes on patients' pain medication, status, activity, etc., some written by hospital personnel, some by the patients themselves

Note

many similar diaries are attached to individual patient's record; RESTRICTED
box 2, folder 19

Pain studies - patient lists. undated.

Scope and Content Note

typed lists; several hand-written lists, grouped by hospital, alphabetically, etc.

Note

RESTRICTED
 

Subseries 2. Tocainide Series

Physical Description: 1 folder
box 2, folder 20

Patients. 1973-1980.

Scope and Content Note

records, notes, lists

Note

see Box 1 - Folders 26, 27 for extensive case summaries [initials only]; RESTRICTED
 

Series 3. Miscellaneous 1957-1984.

Physical Description: 5 folders
box 1, folder 34

Correspondence. 1966-1983.

Scope and Content Note

letters to KEL and his wife after onset of his illness, mostly concerning his professional work; a few earlier letters

Note

for related material, see the Correspondence Series in the main collection, Ms.Coll. #130
box 1, folder 35

Obituaries, memorial. 1984.

box 1, folder 36

Spring Creek property. 1957-1960, 1978.

Scope and Content Note

correspondence, legal and financial papers, notes concerning the acquisition and early development of a 38-acre property in rural Oregon bought by Dr. & Mrs. Livingston and a few others; one later (1978) re-purchase document; financial and other miscellanea
box 1, folder 37

"The Ark". 1962.

Scope and Content Note

three short drafts of a science fiction scenario
box 1, folder 38

The John C. Liebeskind History of Pain Collection. undated.

Scope and Content Note

brochure