Kenneth E. Livingston Papers. Supplement. 1952-1984
Processed by UCLA Biomedical Library staff; machine-readable finding aid created by Caroline Cubé.
Louise M. Darling Biomedical Library History and Special Collections
for the Sciences
History and Special Collections Division for the Sciences
UCLA
12-077 Center for Health Sciences
Box 951798
Los Angeles, CA 90095-1798
Phone: 310/825-6940
Fax: 310/825-0465
Email: biomed-ref@library.ucla.edu
URL:
http://www.library.ucla.edu/libraries/biomed/his/
©2014
The Regents of the University of California. All rights reserved.
Descriptive Summary
Title: Kenneth E. Livingston Papers. Supplement.,
Date (inclusive): 1952-1984
Collection number: 130.1
Creator: Livingston, Kenneth E. 1914-1984
Extent: 2 cartons (2.0 linear ft.)
Repository:
University of California, Los Angeles. Library.
Louise M. Darling Biomedical Library History and Special Collections
for the Sciences
Los Angeles, California 90095-1490
Abstract: The supplement to the main Kenneth E. Livingston
collection (Ms. Collection #130) extends the documentation of his clinical and
research endeavors in limbic system research and in the control of chronic pain.
To his long-term ongoing study of intravenous procaine for pain control, Dr.
Livingston added a small clinical trial on the efficacy of oral tocainide and
was much excited by the results; this later interest is well covered in these
supplemental materials. There are also drafts of ideas and letters concerning
his thoughts on ecology, homeostasis and the brain-mind discussion. All the
Kenneth E. Livingston papers are part of the John C. Liebeskind History of Pain
Collection at UCLA.
Physical location: Southern Regional Library Facility
(SRLF)
Language of Material: Collection materials in English
Access
The Collection is open for research, but access to some materials is
restricted due to patient confidentiality protocols.
Preferred Citation
[Identification of item], Kenneth E. Livingston Papers. Supplement (Manuscript collection 130.1). Louise M. Darling Biomedical
Library History and Special Collections for the Sciences, University of California, Los Angeles.
Acquisition Information
Gift of Mrs. Katherine Livingston, 1998.
Biography
Kenneth Edwin Livingston was born in 1914, in Pendleton, Oregon and died in
Camp Sherman, Oregon, in 1984. He attended Stanford University (BA, 1936) and
Harvard Medical School (MD, 1939), and finished his specialization in
Neurosurgery at the Lahey Clinic, Boston. After service in the U.S. Navy Medical
Corps during World War II he returned to the Lahey Clinic until 1948, when he
relocated to Oregon. In 1960 he was invited to Shiraz University in Iran to
develop the Neurosurgery Service at Nemazee Hospital, and in 1962 was appointed
Visiting Dean at Pahlavi University to develop their Medical School under an
USAID program. For a year after his return to the U.S. in 1966 Dr. Livingston
served as a Consultant to the Department of Health, Education, and Welfare, and
in 1968 he became Professor of Surgery/Neurosurgery at the University of Toronto
and Chief of Neurosurgery at Wellesley Hospital. He served these institutions
until his retirement in 1981.
Dr. Livingston and his Wellesley group did important research in limbic lobe
mechanisms, temporal lobe epilepsy and drug addiction. But it was the question
of pain, what it was and how to ameliorate it, that mainly occupied his mind and
activities in later years. In this interest he followed his father, William K.
Livingston, a renowned neurosurgeon who was equally interested in the problem of
pain.
Scope and Content
The papers augment, and may occasionally duplicate, the documents in the main
collection (Ms. Coll. no. 130). They include material on Dr. Livingston's limbic
system research, and especially on his ongoing studies in the control of chronic
pain. A number of drafts report on his use of procaine injections to treat
patients with intractable pain, and on the possible CNS mechanisms that might
explain the drug's results. In his last years before retirement Dr. Livingston
ran a small clinical trial using oral tocainide for pain control and was
impressed by the results. This supplement includes his reports on the tocainide
trial and his future plans for the drug's use. It also includes a few of his
essays and musings on broader questions of biology and society.
The collection is organized into the following series:
- Series 1. Professional Papers, 1952-1984 . 34 folders
- Series 2. Patients, 1970-1982. 19 folders
- Series 3. Miscellaneous, 1957-1984. 5 folders
Related Material
"Register of the Kenneth E. Livingston Papers, 1935-1984". UCLA Biomedical
Library Ms. Coll. #130. 22 boxes
"Register of the William K. Livingston Papers, 1923-1966". UCLA Biomedical
Library Ms. Coll. #136. 5 boxes
UCLA Catalog Record ID
Indexing Terms
The following terms have been used to index the description of this
collection in the library's online public access catalog.
Subjects
Livingston, Kenneth
E .
Neurosurgery
Pain
Procaine -- therapeutic
use
Tocainide -- therapeutic
use.
Series 1.
Professional Papers.
1952-1984.
Physical Description: 34 folders
box 1, folder 1
Curriculum vitae and Bibliography.
1980.
box 1, folder 2
Department of Health, Education, and Welfare.
1966-1967.
Scope and Content Note
correspondence with Philip R. Lee, M.D., Asst. Secretary for Health and
Scientific Affairs, and other scientists
Note
KEL served one year as a consultant to the Office of the Secretary for
such topics as international health, health manpower, neurological trauma, and
narcotic addiction and drug abuse
box 2, folder 1
The chronic psychiatric patient and psychiatric services
today.
1973-1978.
Scope and Content Note
extensive materials gathered for a proposed monograph on chronic psychiatric
patients - EEG studies, neurological and neurosurgical perspectives, physical
status
Note
RESTRICTED for patient confidentiality
box 1, folder 3
"The surgery of affective disorders".
undated.
Scope and Content Note
thirty-page typed manuscript
box 1, folder 4
Limbic system concept - drafts and notes.
1968- circa 1973.
Scope and Content Note
typed drafts, including presentations at Cushing Society and Poppen
Symposium; handwritten drafts and notes
Note
for related material, see main collection Ms.Coll. #130, Box 9 - Folder
5
box 1, folder 5
Limbic lobe - bibliographic notes.
undated.
Scope and Content Note
handwritten notes on readings, and bibliographic lists
box 1, folder 6
Symposium: "The continuing evolution of the limbic system concept",
Toronto, Nov. 5-6, 1976.
1976.
Scope and Content Note
typed copies of four papers presented by Paul D. MacLean, Walle J.H. Nauta,
Lennart Helmer, and Paul I. Yakovlev (as told to and introduced by Kenneth E.
Livingston); miscellaneous correspondence and announcements regarding the
symposium
Note
proceedings of the meeting were published as " Limbic mechanisms: the
continuing evolution of the limbic system concept", ed. by Kenneth E. Livingston
and Oleh Hornykiewicz. New York: Plenum Press, c1978; the meeting was often
referred to as "The 2nd Limbic System Conference"
box 1, folder 7
Correspondence with Paul I. Yakovlev.
1952-1983.
Scope and Content Note
extensive correspondence; ongoing topics: 1. preservation of the papers and
scientific memorabilia of James W. Papez, including an application for funds to
the Hanna Foundation, 1978, to organize the collection; 2. evolving concepts of
various brain systems, especially the limbic; 3. discussion of plans for the 2nd
[1976] and 3rd [1983] Limbic System Conferences and Dr. Yakovlev's participation
in them; also included: photocopy of an 1944 letter from Dr. James W. Papez to
Dr. Yakovlev describing the composition of the stria medullaris thalami; a list
compiled by KEL of Yakovlev's personal scientific library
Note
a few letters from other correspondents are included
box 1, folder 8
"The continuing evolution of the limbic system concept", by KEL and
Alfonso Escobar. .
undated.
Scope and Content Note
five-page typed manuscript
box 1, folder 9
Kindling.
1978, 1981, undated.
Scope and Content Note
reprint from "Limbic Mechanisms"; miscellaneous correspondence and notes
Note
file title copied from original folder; for related material, also see
main collection Ms.Coll. #130, Box 1 - Folder 21, Box 7 - Folder 38, Box 9 -
Folder 12
box 1, folder 10
International Symposium on Patterns of Limbic System Dysfunction,
3rd, Toronto, May 8-10, 1983.
1982-1983.
Scope and Content Note
planning notes; symposium program and list of registrants; correspondence
regarding organization, and reports of the meeting's success sent to KEL and his
wife
Note
KEL planned and organized the symposium, but was unable to attend
because of illness. The papers were published as: "The Limbic system :
functional organization and clinical disorders", ed. by Benjamin K. Doane and
Kenneth E. Livingston N.Y., Raven Press, 1986
box 1, folder 11
Limbic Mechanisms Research Program.
1975-1982.
Scope and Content Note
"The limbic mechanisms research program, 1967-1982", three pages describing
KEL's involvement, prepared for a report or proposal; summary nine-page progress
report, Oct. 1st, 1975, signed by KEL; newspaper article
box 1, folder 12
Limbic Mechanisms Research Foundation.
1982.
Scope and Content Note
Memorandum, 1982; Report to the Board, 1982, plus Addendum
Note
see also Box 1, Folder 20
box 1, folder 13
"The problem of central modulatory control".
undated.
Scope and Content Note
three-page typed draft of a grant proposal - funding agency not specified
box 1, folder 14
"Temporal lobe epilepsy - a persisting enigma: new strategies for
diagnosis and treatment derived from basic research".
1980.
Scope and Content Note
grant application to the Connaught Fund; background materials
Note
for related material, see main collection Ms.Coll. #130, Box 3 - Folder
14
box 1, folder 15
"A new approach to the management of chronic intractable pain
secondary to advanced malignant disease: a clinical trial - the Princess
Margaret Hospital".
undated.
Scope and Content Note
five-page typed proposal
box 1, folder 16
Seminar/workshops on chronic pain.
1978, 1981.
Scope and Content Note
programs, correspondence, and notes for two workshops: 1. Princess Margaret
Hospital, Toronto, 1979; 2. Saint John, New Brunswick, 1981
Note
for related material, see main collection Ms.Coll. #130, Box 5 - Folder
30
box 1, folder 17
"The intractable pain of advanced cancer: a new approach to
management".
undated.
Scope and Content Note
17-page draft of a paper intended for the "New England Journal of Medicine",
plus comments from an informal reviewer
Note
for related material, see main collection Ms.Coll. #130, Box 9 -
Folders 35 & 38
box 1, folder 18
"Cancer pain: a new approach to the management of intractable
pain".
1981-1982.
Scope and Content Note
grant applications to: 1. The Ontario Cancer Treatment and Research
Foundation; 2. The National Cancer Institute of Canada; correspondence
Note
the two applications are essentially identical
box 1, folder 19
Procaine - narcotic addiction and other potential clinical
uses.
1980 -1981, undated.
Scope and Content Note
proposal for "A Study of the ameliorating effects of intravenous procaine on
narcotic addiction secondary to chronic intractable pain, by P. Carlen,...K.
Livingston,..." - to be carried out with Addiction Research Foundation Clinical
Inst.(ARF), Toronto, patients; proposal by KEL for a study of procaine in rat
brain, to be carried out in ARF labs; KEL draft about potential procaine uses in
drug addiction, emphysema, and other clinical syndromes; letter from ARF
box 1, folder 20
Procaine - KEL's writings.
undated.
Scope and Content Note
short drafts: description of the drug, its history, metabolism and CNS
effects; the problem of chronic pain; clinical trials of procaine for pain
relief: protocol, case summaries of use in malignant and non-malignant
patients
Note
file title copied from original folder; for related material, also see
main collection Ms.Coll. #130, Box 17 - Folder 22
box 1, folder 21
Procaine - research - Pablo.
circa 1979-1981.
Scope and Content Note
c.v. for Pablo Sanhueza, M.D.; short KEL handwritten texts on procaine
experiments in animals; notes; some articles focusing on the drug mexiletine
Note
folder title taken from original folder
box 1, folder 22
Procaine notebook: Limbic Mechanisms Research Foundation - [the Red
Notebook].
circa 1981-1982.
Physical Description: spiral bound notebook
Scope and Content Note
a well-organized report of the entire series of procaine pain studies, from
"The problem of chronic pain" to clinical data and case histories, to
"Unfinished business", prepared for the Limbic Mechanisms Research
Foundation
Note
most of the content duplicates documents in the above "Procaine"
folders; see related notebook [the Blue Notebook] in Box 1 - Folder
27
box 1, folder 23
Procaine - general.
1972-1981.
Scope and Content Note
notes; reprints from other authors
box 1, folder 24
Lidocaine.
1971, 1982.
Scope and Content Note
photocopy of "General pharmacology and toxicology of lidocaine", by Arne
Astrom, in: "Lidocaine in the treatment of ventricular arrhythmias", proceeding
of a symposium, Edinburgh, 1970, ed. by D.B. Scott and D.G. Julian. Edinburgh:
Livingstone, 1971; typed list: "ASTRA scientists, 1971"; two-page chronology,
"The lidocaine timetable", by KEL, 1982
box 1, folder 25
Tocainide and pain.
1981.
Scope and Content Note
history and description of tocainide; its potential for relief of persistent
pain; proposal for a small clinical trial and letters of institutional approval;
softbound manual,"Tocainide: investigator's brochure", issued by Astra
Pharmaceuticals Canada Ltd.
box 1, folder 26
Tocainide clinical trial.
1981.
Scope and Content Note
descriptions of the small tocainide clinical trial; extensive case summaries,
illustrations and graphs; comparison with procaine treatment in some
patients
Note
some overlap with the "Blue" notebook
box 1, folder 27
Tocainide - Limbic Mechanisms Research Foundation - [the Blue
Notebook].
1982.
Physical Description: spiral bound notebook
Scope and Content Note
loose-leaf notebook with information for the Foundation, whose goal was
"...to provide adequate and continuing financial support for highly potential
medical research.... The Foundation is to acquire patents on certain existing
results of the research, to license the patents to a major pharmaceutical
company..."; typed status report on nine donors; some correspondence; photocopy
of a special report from "The New England Journal of Medicine": "Taking
university research into the marketplace".
Note
some overlap with Box 1 - Folder 26; see also "Red" Notebook, Box 1 -
Folder 21
box 1, folder 28
Tocainide - Patent application for "Methods of treating intractable
pain".
1981-1984.
Scope and Content Note
extensive correspondence regarding the patent application for a new use of
the drug tocainide, in pain control; consideration of setting up a Limbic
Mechanisms Research Foundation for the financing of further research with this
drug
Note
see Box 1 - Folders 12, 21, and 27 for more on the Foundation; see also
main collection Ms.Coll. #130, Box 9 - Folders 35,38, Box 2 - Folder
1
box 1, folder 29
Tocainide patent.
1981-1983.
Scope and Content Note
extensive notes; invoices for legal work
box 1, folder 30
Man - Earth - Ecology.
1978, 1981, undated.
Scope and Content Note
nine-page manuscript, "The growing crisis of planet earth: a discussion of
the brain as a model for global ecology"; six-page notes for a presentation,
Boston, August 21, 1978; five-page notes for presentation, 1981; additional
notes and newspaper clippings; letter exchange with Paul MacLean; readings
Note
for related material, see main collection Ms.Coll. #130, Box 6 - Folder
8
box 1, folder 31
Ideas.
1962-1981.
Scope and Content Note
contents of 2 folders with that label: 1. drafts and notes on "A proposal for
the development of a major experimental laboratory at The Wellesley Hospital";
2. draft of "U.S. bombs for peace", a proposal to use bomb nuclear packages in
power plants, with a letter to Albert Szent-Gyorgi; 3. several proposals of
programs for a radio/TV? show named IDEAS, including text of a 1981 paper KEL
presented to the American Association for the History of Medicine; 4.
discussions from two seminars with senior medical students about medical
education
Note
see also folder on Ecology, Box 1 - Folder 31; for related material,
see main collection Ms.Coll. #130, Box 8 - Folder 28
box 1, folder 32
Homeostasis.
undated.
Scope and Content Note
contents of 3 folders with that label: 1. handwritten notes on readings, from
Nauta, Starling, Fulton, Carmon; 2. hand-written and typed notes and drafts
concerning function of the brain; 3. hand-written and typed notes and drafts
concerning man, nature, and their relationship
Note
see also Box 1 - Folder 4 "The central modulation of visceral
homeostatic mechanisms: a contribution to limbic theory"; for other related
material, see main collection Ms.Coll. #130, Box 8 - Folder 32
box 1, folder 33
Grants - financial balances.
1978-1981.
Scope and Content Note
monthly balances for all ongoing projects [some changes over time]
Note
for related materials, see main collection Ms.Coll. #130 - many
entries
Series 2.
Patients.
1970-1982.
Scope and Content Note
Access to patient files is RESTRICTED. Most files contain: KEL's examination
notes; patients' notes on their pain, activity, and emotional status; hospital
and laboratory notes and reports; correspondence with referring physicians,
insurance companies, or government agencies; many files have a handwritten case
summary.
Arrangement
Alphabetical within each sub-series.
Subseries 1.
Procaine Series
Physical Description: 18 folders
Arrangement
alphabetical in separate non-malignant and malignant series
box 2, folder 2
Patients: A.
1975-1979.
Scope and Content Note
3 records
Note
RESTRICTED
box 2, folder 3
Patients: B.
1971-1982.
Scope and Content Note
8 records
Note
RESTRICTED
box 2, folder 4
Patients: C.
1973-1981.
Scope and Content Note
6 records
Note
RESTRICTED
box 2, folder 5
Patients: D.
1977-1978.
Scope and Content Note
5 records
Note
RESTRICTED
box 2, folder 6
Patients: E-G.
1977-1981.
Scope and Content Note
4 records
Note
RESTRICTED
box 2, folder 7
Patients: H-I.
1977-1981.
Scope and Content Note
4 records
Note
RESTRICTED
box 2, folder 8
Patients: J-K.
1973-1978.
Scope and Content Note
5 records
Note
RESTRICTED
box 2, folder 9
Patients: L-N.
1975-1981.
Scope and Content Note
6 records
Note
RESTRICTED
box 2, folder 10
Patients: O-P.
1975-1981.
Scope and Content Note
5 records
Note
RESTRICTED
box 2, folder 11
Patients: Ra-Ri.
1975-1980.
Scope and Content Note
11 records
Note
RESTRICTED
box 2, folder 12
Patients: Ro-Ru.
1973-1979.
Scope and Content Note
6 records
Note
RESTRICTED
box 2, folder 13
Patients: Sa-Se.
1970-1979.
Scope and Content Note
5 records
Note
RESTRICTED
box 2, folder 14
Patients: Sh-St.
1972-1979.
Scope and Content Note
8 records
Note
RESTRICTED
box 2, folder 15
Patients: T.
1973-1981.
Scope and Content Note
6 records
Note
RESTRICTED
box 2, folder 16
Patients: V.
1971-1979.
Scope and Content Note
3 records
Note
RESTRICTED
box 2, folder 17
Patients: W.
1974-1982.
Scope and Content Note
9 records
Note
RESTRICTED
box 2, folder 18
Patient diaries.
1982.
Scope and Content Note
ongoing notes on patients' pain medication, status, activity, etc., some
written by hospital personnel, some by the patients themselves
Note
many similar diaries are attached to individual patient's record;
RESTRICTED
box 2, folder 19
Pain studies - patient lists.
undated.
Scope and Content Note
typed lists; several hand-written lists, grouped by hospital, alphabetically,
etc.
Note
RESTRICTED
Subseries 2.
Tocainide Series
Physical Description: 1 folder
box 2, folder 20
Patients.
1973-1980.
Scope and Content Note
records, notes, lists
Note
see Box 1 - Folders 26, 27 for extensive case summaries [initials
only]; RESTRICTED
Series 3.
Miscellaneous
1957-1984.
Physical Description: 5 folders
box 1, folder 34
Correspondence.
1966-1983.
Scope and Content Note
letters to KEL and his wife after onset of his illness, mostly concerning his
professional work; a few earlier letters
Note
for related material, see the Correspondence Series in the main
collection, Ms.Coll. #130
box 1, folder 35
Obituaries, memorial.
1984.
box 1, folder 36
Spring Creek property.
1957-1960, 1978.
Scope and Content Note
correspondence, legal and financial papers, notes concerning the acquisition
and early development of a 38-acre property in rural Oregon bought by Dr. &
Mrs. Livingston and a few others; one later (1978) re-purchase document;
financial and other miscellanea
box 1, folder 37
"The Ark".
1962.
Scope and Content Note
three short drafts of a science fiction scenario
box 1, folder 38
The John C. Liebeskind History of Pain Collection.
undated.
Scope and Content Note
brochure