Tsien (Roger) Papers

CORRESPONDENCE

Scope and Content of Series

Series 1) CORRESPONDENCE: Tsien's correspondence from 1981-1995, primarily with biochemistry researchers on fluorescent imaging. Arranged alphabetically by surname or corporate name.

Box 1, Folder 1

A - Miscellaneous

Box 1, Folder 2

Adrian, Richard Hume and Lucy 1985-1995

Box 1, Folder 3

Azzone, G.F. 1985

Box 1, Folder 4

B - Miscellaneous

Box 1, Folder 5

Baker, Peter F. 1984-1985

Box 1, Folder 6

Barker, Jeffery L. 1983-1985

Box 1, Folder 7

Baylor, Stephen 1983-1988

Box 1, Folder 8

Bellelli, Andrea 1987

General note

Includes photograph of melanoma B16 cells treated with fluorescent ricin.

Box 1, Folder 9

Berchtold, Martin W. 1991

General note

Includes notes for Tsien's film on Ca²⁺.

Box 1, Folder 10

Berggren, Per-Olof 1985-1988

Box 1, Folder 11

Berridge, Michael J. 1988-1991

Box 1, Folder 12

Blinks, John 1991-1992

Box 1, Folder 13

Bolsover, Stephen 1987-1988

Box 1, Folder 14

Bourne, Geoffrey H. 1982

Box 1, Folder 15

Brown, Edward M. 1984-1987

Box 1, Folder 16

Brunet, Jean-Francois 1991-1993

Box 1, Folder 17

Bullock, Theodore H. 1984

Box 1, Folder 18

Bulman, Robert A. 1981

Box 1, Folder 19

Burke, Thomas J. 1983

Box 1, Folder 20

C - Miscellaneous

Box 1, Folder 21

Carafoli, Ernesto 1986-1993

Box 1, Folder 22

Chen, Tsung-Hsien 1982-1983

Box 1, Folder 23

Chiesi, Michele 1990-1991

Box 1, Folder 24

Cobbold, Peter H. 1984-1990

Box 1, Folder 25

Conn, P. Michael 1982-1985

Box 1, Folder 26

Connor, John A. 1984

Box 1, Folder 27

Covalent Associates (Victor R. Koch) 1985-1987

Box 1, Folder 28

Czerlinski, George 1989-1992

Box 1, Folder 29

D - Miscellaneous

Box 1, Folder 30

Delumeau, J. Christophe 1988-1989

Box 1, Folder 31

Denton, Richard M. 1987

Box 1, Folder 32

Deutsch, Carol 1982-1987

Box 1, Folder 33

Donowitz, Mark 1981-1985

Box 1, Folder 34

E - Miscellaneous

Box 1, Folder 35

Eisenberg, Robert S. 1989-1991

Box 1, Folder 36

F - Miscellaneous

Box 1, Folder 37

Fay, Fredric S. 1984-1992

Box 1, Folder 38

Firtel, Richard A. 1986

Box 1, Folder 39

Forsén, Sture and Sara Linse 1983-1992

Box 1, Folder 40

G - Miscellaneous

Box 1, Folder 41

Geerts, H. 1987

Box 1, Folder 42

Genesis Consulting Services 1992

Box 1, Folder 43

Grattarola, Massimo 1983-1984

Box 2, Folder 1

Gray, Peter T.A. 1985

Box 2, Folder 2

Green, David P.L. 1989

Box 2, Folder 3

Grell, E. 1983

Box 2, Folder 4

Grezes, J-R. 1985

Box 2, Folder 5

Grinstein, Sergio 1982

Box 2, Folder 6

Grynkiewicz, Grzegorz 1984-1993

Box 2, Folder 7

Gupta, Sudhir Kumar 1991

Box 2, Folder 8

H - Miscellaneous

Box 2, Folder 9

Hanley, Michael R. 1986-1987

Box 2, Folder 10

Haugland, Richard (Molecular Probes, Inc.) 1985-1987

Box 2, Folder 11

Heikkila, Reino 1982-1983

Box 2, Folder 12

Holmuhamedov, E.L. 1989-1990

Box 2, Folder 13

Houslay, Miles 1997

Box 2, Folder 14

I - Miscellaneous

Box 2, Folder 15

Inoué, Shinya 1985-1988

Box 2, Folder 16

J - Miscellaneous

Box 2, Folder 17

Jaffe, Lionel 1987-1993

Box 2, Folder 18

Jeromin, Andreas 1990-1993

Box 2, Folder 19

Jouvin, Marie-Hèléne 1993-1994

Box 2, Folder 20

K - Miscellaneous

Box 2, Folder 21

Kito, Shozo 1992

Box 2, Folder 22

L - Miscellaneous

Box 2, Folder 23

Lamb, Trevor D. 1985-1987

Box 2, Folder 24

Lee, A.G. (Tony) 1987

Box 2, Folder 25

Lee, Linda 1994

Box 2, Folder 26

Leong, Denis A. 1985-1986

Box 2, Folder 27

Lester, Henry A. 1984-1990

Box 2, Folder 28

M - Miscellaneous

Box 2, Folder 29

Machen, Terry 1990-1995

Box 2, Folder 30

Meldolesi, Jacopo 1985-1992

Box 2, Folder 31

Modern Cell Biology 1987

Box 2, Folder 32

Moolenaar, Wouter H. 1982-1988

Box 2, Folder 33

N - Miscellaneous

Box 2, Folder 34

Nachshen, Daniel A. 1984

Box 2, Folder 35

Nanjundiah, V. 1991

Box 2, Folder 36

Neher, Erwin 1984-1995

Box 2, Folder 37

Nippon Hoso Kyokai (NHK Enterprises) 1986-1988

Box 2, Folder 38

O - Miscellaneous

Box 2, Folder 39

Ogura, Akihiko 1986-1989

Box 2, Folder 40

P - Miscellaneous

Box 3, Folder 1

Paoletti, Rodolfo 1982

Box 3, Folder 2

Parrilla, Roberto 1983

Box 3, Folder 3

Polito, Vito S. 1985-1986

Box 3, Folder 4

Potter, Barry V.L. 1989-1991

Box 3, Folder 5

Q - Miscellaneous

Box 3, Folder 6

R - Miscellaneous

Box 3, Folder 7

Requena, Jaime 1984

Box 3, Folder 8

S - Miscellaneous

Box 3, Folder 9

Sattelmacher, B. 1991

Box 3, Folder 10

Schmitt-Verhulst, Anne-Marie 1987-1994

Box 3, Folder 11

Semmelhack, Martin F. 1989-1991

Box 3, Folder 12

Sheu, Shey-Shing 1984-1986

Box 3, Folder 13

Simpson, Alec W.M. 1991

Box 3, Folder 14

Sjöholm, Åke 1991

Box 3, Folder 15

Snowdowne, Kenneth W. 1984-1986

Box 3, Folder 16

Somlyo, Andrew P. and Jack H. Kaplan 1988

Box 3, Folder 17

Stryer, Lubert 1989-1991

Box 3, Folder 18

Styrt, Barbara 1987

Box 3, Folder 19

T - Miscellaneous

Box 3, Folder 20

Takai, Yoshimi 1984

General note

Includes photographs of Timothy Rink and Roger Tsien in Tsien's laboratory.

Box 3, Folder 21

Terasaki, Mark 1989-1990

General note

Includes photographs of calcium imaging in sea urchin eggs.

Box 3, Folder 22

Tsien, Richard W. 1986-1991

Box 3, Folder 23

V - Miscellaneous

Box 3, Folder 24

Vijayaraghavan, Sukumar 1993

Box 3, Folder 25

W - Miscellaneous

Box 3, Folder 26

Wang, Cheng-Teh 1987

Box 3, Folder 27

Wang, Jian-xun 1986

Box 3, Folder 27

Wietzerbin, J. 1983

Box 3, Folder 29

Williamson, Richard E. 1982

Box 3, Folder 30

Wilson, H. Alexander (Sandy) 1983-1986

Box 3, Folder 31

Wojnowski, Leszek 1992

Box 3, Folder 32

Wojtowicz, Martin 1991

Box 3, Folder 33

Wung, Chi-Chang 1984

Box 3, Folder 34

Y - Miscellaneous

Box 3, Folder 35

Yoshizawa, Susumu 1991

Box 3, Folder 36

Yuspa, Stuart H. and Henry Hennings 1982

Box 3, Folder 37

Z - Miscellaneous

WRITINGS

Scope and Content of Series

Series 2) WRITINGS: Manuscripts, drafts, correspondence and notes for Tsien's writings on green fluorescent protein, and a bound copy of his Ph.D. dissertation, The Design and Use of Organic Chemical Tools in Cellular Physiology. Also includes a guide and an annotated printout of a computer program written by Tsien for the digital imaging system used in his laboratory. Arranged by title.

Box 4, Folder 1

The Design and Use of Organic Chemical Tools in Cellular Physiology. Ph.D. dissertation submitted to Churchill College, University of Cambridge 1976 September

Box 4, Folder 2-3

Digital imaging computer program - Annotated printout 1992

Box 4, Folder 4

Fluorescence Resonance Energy Transfer (FRET): A Biological Readout for Molecular Proximity undated

Box 4, Folder 5

GFP for Relatively Lay Audiences 1996

Box 4, Folder 6

Green Fluorescent Protein Mutants as Indicators of Phosphorylation. With Andrew B. Cubitt 1998

Box 4, Folder 7-8

Guide to Operating the Ratio Imaging Processing System 1985-1990

Box 4, Folder 9

The Three-Dimensional Structure of Green Fluorescent Protein Resembles a Lantern. With C.-K. Wu, et al 1997

RESEARCH PROJECTS

Scope and Content of Series

Series 3) RESEARCH PROJECTS: Laboratory notebooks, notes, data, and images created by Tsien and members of his lab. Arranged in three subseries: A) Notebooks and Notes, B) Green Fluorescent Protein, and C) Tsien Laboratory.

A) Notebooks and Notes: Research notebooks, notes, and binders kept by Tsien. Nine bound laboratory notebooks from 1972-1995 contain research notes with dated entries. Some volumes include inserted notes, data, and images. Seventy-seven spiral bound notebooks from 1972-2010 were numbered by Tsien and contain research notes, notes on scientific publications, personal notes, and appointments. Many of the entries are undated. Four unlabeled research binders with data and notes from 1982-1991 were numbered during processing. Tsien also kept notebooks on calcium and sodium ion chelators, and notes on software and electronic circuits.

B) Green Fluorescent Protein: Correspondence, notes, data and images regarding green fluorescent protein research, as well as laboratory protocols written by chemist Alice Y. Ting while she was a postdoctoral researcher in Tsien's lab.

C) Tsien Laboratory: Laboratory notebooks kept by members of Tsien's lab, including Akwasi Minta, Carsten Schultz, Grzegorz Grynkiewicz, Javier Garcia-Sancho, Lewis R. Makings, Tito Gonzalez, and Wenhong Li. Topics include nuclear magnetic resonance, chelators, buffers, and dyes.

Notebooks and Notes

Box 4, Folder 10-11

Ca²⁺ chelators - Biology 1983

Box 5, Folder 1-3

Ca²⁺ chelators - Chemistry 1983-1988

Box 5, Folder 4

Close-Up modem remote communications software - Notes 1994

Box 5, Folder 5

General IC and semiconductor specifications - Notes

Box 5, Folder 6-9

Laboratory notebooks 1972 October 16-1977 July 18

Box 6, Folder 1-5

Laboratory notebooks 1977 July 18-1995 January 2

Box 6, Folder 6

Na⁺ chelators 1985-1988

Box 6, Folder 7-8

Notebooks #1-2 1972

Box 7, Folder 1-11

Notebooks #3-13 1973-1977

Box 8, Folder 1-10

Notebooks #14-23 1977-1982

Box 9, Folder 1-9

Notebooks #24-32 1983-1990

Box 10, Folder 1-9

Notebooks #33-41 1990-1994

Box 11, Folder 1-8

Notebooks #42-49 1995-1998

Box 12, Folder 1-8

Notebooks #50-57 1998-2002

Box 13, Folder 1-6

Notebooks #58-63 2002-2005

Box 14, Folder 1-8

Notebooks #64-71 2005-2008

Box 15, Folder 1-6

Notebooks #72-77 2008-2010

Box 15, Folder 7-8

Research binder #1 1982-1983

Oversize FB-529, Folder 4

Research binder #2 1983-1984

Box 16, Folder 1-7

Research binders #3-4 1983-1991

Green Fluorescent Protein

Box 16, Folder 8

Correspondence 1994-2004

Box 16, Folder 9

Laboratory protocols by postdoctoral researcher Alice Y. Ting 2002

Box 16, Folder 10

Notes, data and images 1994-1996

Box 17, Folder 1-2

Notes, data and images 1984-2002

Tsien Laboratory

Box 17, Folder 3-6

Akwasi Minta - Nuclear Magnetic Resonance (NMR) 1983-1987

General note

FLUO and Rhod precursors. Orthoesterification. BAPTA. Sodium and potassium. Miscellaneous.

Box 17, Folder 7

A.M. #1. A) Dyes, B) Sodium chelators, C) Oxygen chelators, D) Buffers 1983-1984

Box 18, Folder 1-4

Carsten Schultz - Journals #1-3 and NMR Spectra 1990-1993

Box 18, Folder 5-7

Grzegorz Grynkiewicz - NMR-I and II 1983-1984

General note

Experimental procedures, BAPTA derivatives, model heterocycles and their immediate precursors. Substrates, etc. Acetals and TMSX reactions.

Box 19, Folder 1-3

Grzegorz Grynkiewicz - NMR-II, and untitled notebook 1983-1984

General note

Acetals and TMSX reactions. Spect. Greg's models.

Box 19, Folder 4

Javier Garcia-Sancho - Selected results and summary undated

Oversize FB-529, Folder 5

Laboratory notebook. 1) Acetylinic dyes 2) Fluorenone dyes 3) Na⁺ (Acridine chem.) 4) Cyanine dyes 1984-1987

Box 19, Folder 5

Lewis R. Makings - LRMI 1985-1989

Box 19, Folder 6-7

Tito Gonzalez - Laboratory notebooks #1-2 1993-1995

Box 20, Folder 1-2

Tito Gonzalez - Laboratory notebooks #4-5 1995-1996

Box 20, Folder 3-5

Wenhong Li - LIW-INO, LIW-IN (95D) and 94 M 1993-1996

TEACHING MATERIALS

Scope and Content of Series

Series 4) TEACHING MATERIALS: Correspondence, lecture notes, syllabi, course reviews, exam questions, and images for courses and seminars taught by Tsien in cell biology, biochemistry, pharmacology, pathology, and organic chemistry.

Box 20, Folder 6

BMS 210: Cell Biology 1990-1994

Box 20, Folder 7

BMS 212: Principles of Cellular Pharmacology 1992

Box 20, Folder 8

BMS 224: Basic Science Discovery Connects to Therapeutics seminar 1997

Box 20, Folder 9

BMS 229: Methods in Pharmacology 1990-1991

Box 20, Folder 10

BMS 230: Receptors and Signal Transduction. With Timothy J. Rink 1988-1999

Box 20, Folder 11-12

BMS 231: Contemporary Topics in Pharmacology. With Palmer Taylor 1992-2003

Box 20, Folder 13

BMS 297: Introduction to Research 1990

Box 21, Folder 1-2

CBB Reading Group: Drugs of the Future 1996-2001

Box 21, Folder 3-4

CBB Reading Group: Modern Techniques in Drug Discovery 1998-2001

Box 21, Folder 5-8

Chemistry 140: Organic Chemistry 1988-1994

Box 22, Folder 1

CMPP 217: Cellular and Molecular Physiology/Pharmacology 1989

Box 22, Folder 2

MED 260: Modern Techniques of Biomedical Research 1993-1994

Box 22, Folder 3

Neurosciences 234: Molecular and Cellular Neurochemistry 1996-1998

Box 22, Folder 4

Pathology 231: Modern Methods in Cellular and Molecular Pathology 1992-1993

Box 22, Folder 5

SOM 204: Cell Biology and Biochemistry 2001

Box 22, Folder 6

UC San Diego Department of Chemistry and Biochemistry 2001-2004

VIDEO RECORDINGS

Scope and Content of Series

Series 5) VIDEO RECORDINGS: VHS videocassette recordings on the use of fluorescent proteins and dyes in intracellular imaging by Roger Tsien and other researchers at UC San Diego, in NTSC and PAL formats. Notes for a film on calcium imaging can be found in the CORRESPONDENCE series under Berchtold. Original video recordings are restricted; researchers may request viewing copies in advance of their visit.

Box 23, Folder 1

Ca²⁺ cAMP images. Roger Tsien, UC San Diego 1993

General note

PAL videocassette.