Contains the records of the Radiologic Imaging Laboratory (RIL) of the University of California, San Francisco (UCSF) from
its initial funding by Pfizer, Inc. through its operation as a unit of Diasonics, Inc. and Toshiba America MRI (TAMI). Material
relates to the RIL's development and sale of magnetic resonance imaging (MRI) technology, dated 1963-2006.
Radiologic Imaging Laboratory History: In 1975, the UCSF Department of Radiology, under the direction of Alexander Margulis, founded a small research and development
group to investigate new medical diagnostic imaging instruments and systems. The team included electrical engineers, radiofrequency
coil experts, computer scientists, and medical researchers. They sought in part to create a clinically viable diagnostic tool
using nuclear magnetic resonance imaging, later called magnetic resonance imaging (MRI). They focused on creating a machine
capable of safely and effectively capturing scanned images of the living human body. In 1978 the lab, now called the Radiologic
Imaging Laboratory (RIL), opened an off-campus facility at 400 Grandview Drive in the Cabot, Cabot and Forbes Industrial Park
in South San Francisco. Leon Kaufman served as chief scientist and director and Lawrence Crooks served as assistant director
and electrical engineer. RIL researchers regularly consulted with physicians to initiate patient and animal studies and better
understand how pathologies impact the imaging of tissue. They experimented with magnet technology and designed new computer
hardware and software to improve MRI machine availability, image quality, speed, and sensitivity. RIL originally received
funding from the Pfizer Corporation under an agreement with the UCSF Radiology Department. In late 1981, Pfizer discontinued
its imaging activities and Diasonics purchased the project. In 1989, Toshiba acquired RIL from Diasonics. In 1994, RIL separated
from the University and became a unit of Toshiba America called TAMI RIL. RIL researchers secured numerous patents and received
royalties for their technology. In the 1990s, following royalty and patent disputes with UCSF regarding imaging technology,
UC Berkeley professor Jerome R. Singer (later joined by Lawrence Crooks) sued the Regents of the University of California.
The RIL ceased operation in 2001.
102 Linear Feet
(72 cartons, 8 boxes, 6 oversize boxes, 4 flat file drawers)
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