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O'Brien (John) Papers
MSS 0606  
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BIOGRAPHICAL MATERIALS

Scope and Content of Series

Series 1) BIOGRAPHICAL MATERIALS: Curricula vitae, photographs, and materials pertaining to O'Brien's postdoctoral fellowship with the National Heart Institute.
Box 1, Folder 1

Biographical sketch

Box 1, Folder 2

Curriculum vitae 1961

Box 1, Folder 3

Photographs of O'Brien 1969

Box 1, Folder 4

U.S. Public Health Service - Postdoctoral research fellowship 1958 - 1961

General

Applications and correspondence.
 

CORRESPONDENCE

Scope and Content of Series

Series 2) CORRESPONDENCE: Correspondence with Michael M. Kaback, who organized and led the first Tay-Sachs screening program among Jewish citizens of Baltimore and Washington in 1971. Also chronological files documenting O'Brien's medical research.
Box 1, Folder 5

Kaback, Michael M. 1970 - 1993

Box 1, Folder 6-10

Chronological files 1959 - 1965

Box 2, Folder 1-7

Chronological files 1965 - 1967

Box 3, Folder 1

Chronological files 1968 - 1977

 

WRITINGS

Scope and Content of Series

Series 3) WRITINGS: O'Brien's published and unpublished writings on folic acid, lipids, and lysosomal storage diseases. Arranged in two subseries: A) Articles, and B) Notes.
A) Articles: Typescripts, notes, correspondence, and photographs for O'Brien's research articles. Arranged chronologically.
B) Notes: O'Brien's notes on lysosomal storage disorders, including Gaucher disease and metachromatic leukodystrophy (MLD).
 

Articles

Box 3, Folder 2

List of publications 1958 - 1998

Box 3, Folder 3

A Bioautographic Technique for Assay of Folic and Folinic Acids 1958

General

Typescript of master's thesis in physiology, Creighton University.
Box 3, Folder 4

Simultaneous Fe-59 and Cr-51 Study in Evaluation of Erythrokinetics 1958 - 1964

General

Typescripts, notes, and correspondence.
Box 3, Folder 5

The Folate Coenzymes. I. The Occurrence of Folate Forms in Leucocytes. II. A Review of the Chemistry and Biology of the Folate Coenzymes 1960

General

Typescript of M.D. thesis, Creighton University.
Box 3, Folder 6

Hypogammaglobulinemia and Hypersplenism Associated with Lymphosarcoma of the Spleen: Normal Gamma Globulins Post Splenectomy. With John R. Walsh 1961

General

Typescripts, notes, and illustrations.
Box 3, Folder 7

Role of Folate Coenzymes in Cellular Division 1961 - 1962

General

Typescripts, correspondence, and illustrations. Published in Cancer Research.
Box 3, Folder 8

Folinic Acid Activity in Leucocytes. With John R. Walsh 1962 - 1963

General

Drafts and typescripts. Published in Proceedings of the Society for Experimental Biology and Medicine 109: 843-847, 1962.
Box 3, Folder 9

Tissue Distribution of Glycosphingolipids in a Case of Fabry's Disease. With James M. Schibanoff and Shigehiko Kamoshita 1966

General note

Drafts, notes, correspondence, photographs and illustrations. Published in The Journal of Lipid Research, Vol. 10.
Box 3, Folder 10-11

Lipid Composition of the Brain in Late Infantile Amaurotic Idiocy (Jansky-Bielschowsky Type). With Hyakuji Yabuuchi and George B. Reed 1967 - 1969

General

Typescripts, photographs, research notes and correspondence.
Box 3, Folder 12

Fucosidosis: Diagnosis by Serum Assay of Alpha-L-Fucosidase. With Klaus Zielke, et al 1968

General

Typescript, notes, and illustrations.
Box 4, Folder 1

Lipid Composition of the Nervous System in Refsum's Disease. With Monica C. MacBrinn 1968

General

Typescripts, correspondence, and photograph.
Box 4, Folder 2

I-Cell Disease: Biochemical Studies. With Jules G. LeRoy, et al 1968 - 1972

General note

Typescripts, notes, photographs, and correspondence. Published in Pediatric Research 6: 752-757 (1972).
Box 4, Folder 3

Sanfilippo Disease Type B: Detection of Homozygotes and Heterozygotes by Leucocyte Alpha-Acetylglucosaminidase Assay 1971 - 1973

General

Typescript and research notes.
Box 4, Folder 4

Partial Purification of Alpha-N-Acetylglucosaminidase and Some of its Properties. With Audre W. Loverde 1972 - 1975

General

Typescript, correspondence, and research notes.
Box 4, Folder 5

Binding of Human Liver Beta-Galactosidases to Plant Lectins Insolubilized on Agarose. With Anthony G.W. Norden - Typescript 1973

Box 4, Folder 6

Purification of Human Placental Alpha-L-Fucosidase by Affinity Chromatography. With Jack A. Alhadeff and A.L. Miller 1974

General

Typescript. Published in Analytical Biochemistry.
Box 4, Folder 7

Human Liver Alpha-L-Fucosidase. With Jack A. Alhadeff, et al 1974 - 1975

General

Typescripts, correspondence, notes, and photographs. Published in The Journal of Biological Chemistry 250 (8): 1975.
Box 4, Folder 8

Characterization of Canine Liver Acid Beta-D-Galactosidase. With Jeffrey J. Hubert 1975 - 1980

General

Typescript, research notes, and correspondence.
Box 4, Folder 9-10

Adrenoleucodystrophy: Deficiency of Acid Esterase Isozymes. With M. Lois Veath and Linda Tennant 1977 - 1979

General

Typescripts, research notes, and photographs.
Box 4, Folder 11

Electrophoretic Analysis of Glycoprotein Enzymes in the Sialidoses and Mucolipidoses. With D.M. Swallow, et al 1979 - 1981

General

Reference notes, correspondence, annotated proof and photographs.
Box 4, Folder 12

Canine GM1 Gangliosidosis: An Ultrastructural and Biochemical Study. With Moses Rodriguez, et al 1980 - 1982

General

Typescript, research notes, and photographs.
Box 4, Folder 13

Molecular Cloning of a cDNA for Human Alpha-L-Fucosidase. With Hisao Fukushima, et al 1985

General note

Abstract typescript. Published in Proceedings of the National Academy of Sciences 82: 1262-1265, February 1985.
Box 4, Folder 14

Molecular Biology of the Alpha-L-Fucosidase Gene and Fucosidosis. With Patrick J. Willems, et al 1987 - 1989

General

Typescript, correspondence, notes, reviews, and photograph.
Box 4, Folder 15

Bone Marrow Transplantation in Canine GM1 Gangliosidosis. With Robert Raff, et al 1988 - 1990

General

Typescript, correspondence, and research notes.
Box 5, Folder 1

Characterization of the EcoRI Mutation in Fucosidosis Patients: A Stop Codon in the Open Reading Frame. With Keith A. Kretz, et al 1989

General

Typescript and annotated reprint. Published in Journal of Molecular Neuroscience, 1989.
Box 5, Folder 2

Isolation, Characterization, and Mapping of a Human Acid Beta-Galactosidase cDNA. With Yoshimi Yamamoto, et al - Typescript 1989

Box 5, Folder 3

Three Lysosomal Enzymes 1991 - 1996

General

Grant renewal application to the National Institutes of Health.
Box 5, Folder 4

Abstracts of published articles 1996 - 1998

Box 5, Folder 5

Prosaposin, the Saposin Proteins and Prosaptides - Typescript 1998

Box 5, Folder 6

List of abstracts and manuscripts presented or work in progress sponsored by the Myelos Neurosciences Grant 1998 - 1999

Box 5, Folder 7

List of publications submitted by UC San Diego O'Brien Group 1998 - 1999

Box 5, Folder 8

Chromosome 1 Localization of the Human Alpha-L-Fucosidase Structural Gene with a Homologous Site on Chromosome 2. With M.L. Fowler, et al

General

Typescript. Published in Cytogenetics and Cell Genetics.
Box 5, Folder 9

Electrophoretic Forms of Human Liver Alpha-L-Fucosidase and Their Relationships to Fucosidosis (Mucopolysaccharidosis F). With Jack A. Alhadeff, et al - Typescript

Box 5, Folder 10

Fabry's Disease: Retention of an Alpha-Galactosidase Lacking Ceramide Trihexosidase Activity. With Anthony G.W. Norden - Typescript and notes

Box 5, Folder 11

Prenatal Diagnosis of Tay-Sachs Disease and Generalized Gangliosidosis. With Shintaro Okada - Typescript

 

Notes

Box 5, Folder 12

Adrenal cortex 1973

Box 5, Folder 13

Cerebral lipidoses - Notes and graphs 1961 - 1963

General

Notes and graphs.
Box 5, Folder 14

Gaucher disease 1961

Box 5, Folder 15

Genetics of MLD (Metachromatic leukodystrophy)

General

Compiled by Alfred Knudsen and John O'Brien.
 

TEACHING

Scope and Content of Series

Series 4) TEACHING: Lecture notes, teaching materials, and visual aids for seminars and course lectures given at UC San Diego and other institutions. Arranged alphabetically.
Box 5, Folder 16

Folic Acid seminar 1962 - 1963

General

Notes, typescript, and photographs.
Box 5, Folder 17

Lecture notes 1961 - 1973

Box 5, Folder 18

Seminar talks and course lectures - Notes 1963 - 1970

Box 5, Folder 19

UC San Diego Neurosciences 234: Molecular and Cellular Neurochemistry and UC San Diego Basic Neurology: Molecular Anatomy of Myelin - Lecture notes 1969 - 1989

 

TAY-SACHS

Scope and Content of Series

Series 5) TAY-SACHS: Newspaper articles, press releases, correspondence, manuscript drafts, proposals, and pamphlets documenting O'Brien's discovery of the genetic cause of Tay-Sachs disease and his role in the establishment of widespread genetic screening, education, and counseling. Arranged alphabetically.
Box 5, Folder 20

California Tay-Sachs disease prevention program 1977 - 1978

Box 5, Folder 21

Cost benefit analysis of Tay-Sachs disease 1971 March

General

Typescript by O'Brien.
Box 5, Folder 22

Donation letter

General

Form letter requesting donations for Tay-Sachs research.
Box 5, Folder 23

National Tay-Sachs and Allied Diseases Association 1970 - 1977

General

Correspondence, meeting minutes, pamphlets, and directory.
Box 6, Folder 1

Newspaper articles, press releases and correspondence 1969 - 1971

Box 6, Folder 2

Progress in Tay-Sachs Disease to October 1969 1969

General

Typescript by O'Brien.
Box 6, Folder 3

San Diego Tay-Sachs screening program 1971 - 1974

General

Correspondence, pamphlets, notes, and news clippings.
Box 6, Folder 4

Tay-Sachs disease 1961 - 1972

General

Notes, annotated reprints, and correspondence.
 

RESEARCH

Scope and Content of Series

Series 6) RESEARCH: Research notes, correspondence, and photographs relating to O'Brien's laboratory research on Tay-Sachs disease and other genetic disorders in humans and animals. Arranged alphabetically.
Box 6, Folder 5

4MU-Neuraminidase fibroblast assay - Research notes 1978

Box 6, Folder 6

Adrenoleucodystrophy - Cholesterol lignocerate assays. Research notes 1976 - 1977

Box 6, Folder 7

Alpha-galactosaminidase - Research notes 1971

Box 6, Folder 8

Alpha-L-fucosidase purification - Research notes 1981

Box 6, Folder 9

Antibody PPTN of beta-gal 1975

General

Research notes and slides.
Box 6, Folder 10

Beagle beta-gal normal 1978 - 1994

General

Research notes and photograph.
Box 6, Folder 11-12

Beta-gal purification 2 - Research notes 1974 - 1979

Box 7, Folder 1

Beta-gal structural study - Research notes 1982 - 1984

Box 7, Folder 2

Biochemical processes - Diagrams and charts

Box 7, Folder 3

Brain biopsy - Proposal 1965

Box 7, Folder 4

Canine fucosidosis 1982 - 1987

General

Correspondence and research notes.
Box 7, Folder 5

Cerebroside-beta-galatosidase and lactosylceramide galactosidase assays 1972 - 1974

General

Research notes, correspondence, and photograph.
Box 7, Folder 6

Cerebroside SO4 1959 - 1965

General

Research notes, graph, and annotated reprints.
Box 7, Folder 7

Cloning alpha-fucosidase 1982 - 1991

General

Correspondence and research notes.
Box 7, Folder 8-9

Cloning alpha-hexosaminidase - Research notes 1983 - 1984

Box 7, Folder 10

Cloning beta-galactosidase 1982 - 1993

General

Research notes and correspondence.
Box 7, Folder 11

Cloning beta-galactosidase cDNA - Research notes 1986 - 1989

Box 7, Folder 12

Cloning human ASA 1983 - 1987

General

Research notes and correspondence.
Box 8, Folder 1

Cloning human beta-gal 1982 - 1985

General

Research notes, photographs, and correspondence.
Box 8, Folder 2

Construction of E. coli beta-gal vector - Helinski's lab 1982

General

Research notes and correspondence.
Box 8, Folder 3

Cystic fibrosis - Lab experiments 1969 - 1978

General

Research notes and photographs.
Box 8, Folder 4

D1 goia sud leuk 1965 - 1974

General

Research notes and photographs.
Box 8, Folder 5

DNA sequences - Alpha fuc sapl glu-cer 'ase 1985

General

Research notes and correspondence.
Box 8, Folder 6

Fat study - Research notes 1960 - 1961

Box 8, Folder 7

Fetal newborn livers vs. isoenzyme patterns 1970 - 1971

General

Research notes and photographs.
Box 8, Folder 8

Florisil cols for cer SO4 - Research notes 1963

Box 8, Folder 9

Frozen tissue - Diseased 1962 - 1968

General

Correspondence, research notes, and photographs.
Box 8, Folder 10

Frozen tissue - Normal 1962 - 1963

General

Research notes and photographs.
Box 8, Folder 11

Fucosidosis - Lipids, etc. Research notes 1987

Box 9, Folder 1

Fucosidosis - Northern studies 1985 - 1987

General

Research notes, proposal, correspondence, and photograph.
Box 9, Folder 2

GA2, globoside labeling, GM2, and assays 1972-1980

General

Research notes and photographs.
Box 9, Folder 3

GA2 hexosaminidase preparation of GA2H3 and assays - Research notes 1974 - 1975

Box 9, Folder 4

Ganglioside assays - Research notes

Box 9, Folder 5

GLC hex and hexoseam - Research notes 1963

Box 9, Folder 6

GM1 - Animal models 1973 - 1980

General

Research notes and correspondence.
Box 9, Folder 7

GM1 - Labeling, assays and ASF. Research notes 1973 - 1988

Box 9, Folder 8

GM2 activator - Correspondence and notes 1980

Box 10, Folder 1

GM2 assays #2 1974 - 1981

General

Research notes and correspondence.
Box 10, Folder 2

GM2 gangliosidosis (types) 1964 - 1970

General

Research notes, correspondence, and photographs.
Box 10, Folder 3

GM2H3 hexosaminidase - Research notes 1974 - 1975

Box 10, Folder 4

GM3 neuraminidase - Research notes 1978

Box 10, Folder 5

Hexosaminidase in serum - Research notes 1969 - 1972

Box 10, Folder 6

Hexosaminidase isol - Research notes 1982 July

Box 10, Folder 7

HPLC galactosyl ligosaccharides - Research notes 1978

Box 10, Folder 8

I-cell disease research 1968 - 1976

General

Research notes and photographs.
Box 10, Folder 9

Leukodystrophy cat, Washington State University, Pullman 1973 - 1976

General

Correspondence, research notes, and photographs.
Box 10, Folder 10

Lipid separation methods - Research notes 1958 - 1963

Box 10, Folder 11

Lipidosis bonnet macaque 1982

General

Research notes and photographs.
Box 10, Folder 12-13

Micrographs 1971 and undated

General

Photomicrographs of cells affected by Tay-Sachs and other disorders.
Box 10, Folder 14

MPS - Gel electrophoresis. Research notes 1978

Box 10, Folder 15

mRNA isolation - Research notes 1982

Box 10, Folder 16

NANA assays - CMP-NANA synthetase preparation 1971 - 1975

General

Research notes and correspondence.
Box 10, Folder 17

Neuraminidase assays - Research notes 1977 - 1978

Box 11, Folder 1

Neurometabolic disorders (general) 1972

General

Diagnosis of lipidoses and leucodystrophies chart.
Box 11, Folder 2

Normal human beta-gal isolation - Research notes 1979 - 1983

Box 11, Folder 3

Oligosaccharide purification 1978

General

Research notes, photograph, and annotated reprint.
Box 11, Folder 4

Phospholipase assay - Research notes 1980

Box 11, Folder 5

Portuguese water dogs - Storage disease 1980 - 1990

General

Research notes and correspondence.
Box 11, Folder 6-7

Refsum's disease myelin 1967

General

Research notes, photographs, and correspondence.
Box 11, Folder 8

Sandhoff's disease 1969 - 1978

General

Research notes, correspondence, and photographs.
Box 11, Folder 9

Sanfilippo type B - Enzyme replacement 1973

General

Research notes and photographs.
Box 11, Folder 10

Skin biopsies enzyme assays 1969 - 1971

General

Research notes and correspondence.
Box 11, Folder 11

Sphingomyelinase and phosphodiesterase exps. and P32 turnovers 1975 - 1976

General

Research notes and correspondence.
Box 11, Folder 12

Sphingomyelinase assay 1973 - 1974

General

Correspondence and research notes.
Box 12, Folder 1

Standard preparation methods - Research notes 1962 - 1964

Box 12, Folder 2

Studies on hex A and B - TS vs. normal liver 1974 - 1975

General

Research notes and correspondence.
Box 12, Folder 3

Tay-Sachs - 1554 lipids. Research notes 1962 - 1963

Box 12, Folder 4

TLC densitometry - Research notes

Box 12, Folder 5

Transfection - Beta-gal histo. Research notes 1978 - 1982

Box 12, Folder 6

Unusual beta-gal mutants 1974 - 1976

General

Research notes and correspondence.
 

ORGANIZATIONS

Scope and Content of Series

Series 7) ORGANIZATIONS: Minutes, correspondence, reports, and contracts regarding the Neurosciences Education and Research Foundation, a nonprofit organization of which O'Brien was president, and of Myelos Neurosciences, Inc. The corporation was founded by O'Brien to exploit research discoveries of the saposin proteins done at O'Brien's laboratory for treatment of pain associated with post-polio syndrome, Alzheimer's disease, and central nervous system disorders.
Box 12, Folder 7-8

Myelos Neurosciences - Consulting - Cytokine Derived Peptides as Therapeutics 1993 - 2000

General

Contracts, financial reports, and correspondence.
Box 12, Folder 9

Neurosciences Education and Research Foundation 1994 - 1999

General

Correspondence, minutes, and financial status reports.
Box 12, Folder 10

UC San Diego Technology Transfer Office - Invention and technology disclosure - Myelos Neurosciences 1995 - 1998

General

Correspondence, disclosure forms, budget reports, and notes.